Sequence alignment for CL0252

PF07290

F5ZCI8_ALTSS/9-205ANFWFSIALATVAILFIIEIVGLVFGISMVGLLDDMPNSNIDVESSS.............ILSFGSWLNLDRVPLLIWLV
Q07X14_SHEFN/9-209ANIPFSIALAIVVILGMFEIIALIAGLSVFSALDNWFSLDVDTDVDTTVSVTG.......MTGILGWLCLNRLPLLIWFV
F9ZW07_METMM/8-202QSLPFTAALVLVLLIGIVETLAVLSGLTLSGWLDTLFIDSLPGA................TDSWLGWLHVGRVPVLVLLV
Q3SGS5_THIDA/10-199..WLFSAALVVVVGIGALELFALAVGGSLSSVVDGFVGEAPDGGG...................LAWLHVGRLPFLVILV
Q8EH54_SHEON/10-209.NLPYTIAFACVLVLGVFEALALLIGLSMMSALDQWVPADVEYDADIGGS..G.......LTGIAGWLCLNRLPLLIWFV
YQIJ_ECOLI/7-203YNTPYLFAISFVLLIGLLEIFALICGHMLSGALDAHLDHYDSITTGH.............ISQALHYLNIGRLPALVVLC
Q8ZLY8_SALTY/7-203YNSPYLFAIAFVFFIGVLEMISLIFGHFLSGALDAHLDHYDALSSGP.............AGQALHYLNIGRVPALVVLC
A3QBG8_SHELP/8-207DNLPYSLALALVILLGLVEGFSMVFGLSLFGLLDDLTPMEMDADVDTGVS..G.......VTGVAGWLCLDRLPLLIWLV
C5ATC6_METEA/15-212...PFTLAAVVMAGLVAVEALSLLLGQSLSGLVDGAL..GHEAGSGGDLTSAADADAAFSPAAVMSWINLGRVPFLILLI
W0A7V1_9SPHN/12-199ENIAFSVALALMVLIGLVEALGL.GAASIDVDLDLHLPD.....................AAAPLHWLGIGRVPLLVLLI
Q89LS4_BRADU/12-206EVRPFAIAAAMIVIVGSLEVVTMLVGASLSEMLGTSIDFSHPSDNG..............VLNAISWINVGGVPLLIFLL
B8CU10_SHEPW/9-204ENLPYVISLCIVGILGIVESLSLVIGASFLGLLDDWAPNDAGNDVGG.............VTGLAGWLCISRLPLLIWFV
F2GCT2_ALTMD/9-203SNFWFSIALIAVFIVFVLELIGTIFGASVLGVGDDFGELDSEGFL...............NTAFANFLNINKVPFLIYLI
Q2K5I3_RHIEC/8-199ECLPFAIAAAVLAGLTVIEMLATVMGFSITELLGKPDLHGHDG.................VAGYLSWLNVGGVPLLILLM

PF01957

A9CFM6_AGRT5/13-153------SWWIVGFVLLAAEL..--------------------------------------.IAPGVFLIWIGLAALVIGV
Q9Y9Y8_AERPE/348-492------ILIIGGAILVFIELY.--------------------------------------.TPGFGIIGGTGIAMLVFGV
Q8ZYJ1_PYRAE/276-427------ALIIMGAVLIMAEILM--------------------------------------GMAAHGAVAGVGAVLLIIGF
Q9HJ87_THEAC/279-427------LLLLMGSVLIILEA..--------------------------------------.KMGHGFALLSGVVVGLIGT
O28493_ARCFU/290-429------LLIVLGVIFLFAELM.--------------------------------------.TPTYGVLGAASVVSVVLGL
Q8U0Q2_PYRFU/295-442------LLIIVGMLFFVAEAL.--------------------------------------.TPTFGLFTVAGLISFILGG
Q9HTX9_PSEAE/12-149------DWLAFGTVLLLLEI..--------------------------------------.FGAGGYLLRVGLTAACVGA
Q8P6T7_XANCP/7-144------AWAVLALLLIAAET..--------------------------------------.LAPGAFLLWMGIAAAAVCV
Q9KD63_BACHD/294-444------ILFIAGFLLILIEVF.--------------------------------------.MPGFGLFGILGIAGMIGGM
Q9CME2_PASMU/11-149------HWLILGFVLLIAEL..--------------------------------------.VIPGVFLLWWGLAAIVIAG
Q92UL2_RHIME/331-469------GLILLGAGLLVAEAH.--------------------------------------.APSFGVLGLGGTVALVLGA
Q8KE94_CHLTE/294-434------LLILLAILFFGLEIF.--------------------------------------.VVSSGALAIAGLVALFIGS
Q8RCN5_THETN/296-434------LLVILGLVLLASEAF.--------------------------------------.VVSHGILAVGGIISFVLGS
Q9I667_PSEAE/298-439------ALIALGLAFMVGEAF.--------------------------------------.VASFGVLGIGGIVSFVVGA
Q98H58_RHILO/13-153------NWMVLGFVLLVMEI..--------------------------------------.IAPGIFMLWIGIAALIIGA
P71767_MYCTU/6-144------IWLIAALVLVGAEALT--------------------------------------GDMFLLMLGGGALAASVSSW
Q98JI0_RHILO/328-465------ALMLLGIAFLVIEAL.--------------------------------------.NPTV.VLGVSGVAAFLFGA
Q8Y187_RALSO/320-464------ALLALGLGCMVAEAF.--------------------------------------.LPTFGALGVGGIIAFILGA
Q8TS89_METAC/290-434------FLIIVGIGLLILELN.--------------------------------------.SPGFGIFGLAGIICLVIGS
Q8NQA4_CORGL/8-145------IWFIGALVLAGLELAV--------------------------------------GEFTLLMLGGAALATAGVAL
Q97K68_CLOAB/7-143------IWIIIAIFMVVIDFGT--------------------------------------SGFLFVWFSAGAVVAIIAGL
Q9CBM4_MYCLE/6-143------VWLIFALVLACAEALT--------------------------------------GDMFLLMLGGGALASAVSGW
O67682_AQUAE/286-425------LLIVLGILFFVLELL.--------------------------------------.TPTFGALALGGAISILLGS
Q2K1C3_RHIEC/306-441------.LIFLGVGLTVAEAH.--------------------------------------.SPSFGAFGIGGGIAVILGA
Q2YIT1_BRUA2/13-150------NWLVFGLILLILEI..--------------------------------------.LAPGFFFIWFGLAALVIGA

PF07290

F5ZCI8_ALTSS/9-205VLLTIFGLLGFVTNFATQSI----ANITLPVWVTLPFSAIVGTLLTSKVSVIIAVVIPK-FQTSAIQNDDFIGAVAHITI
Q07X14_SHEFN/9-209LALSSFAIAGYVINFGYSQL----FGSFLPQIITVPVALVIMFFSSHFIGNGIANILPK-NETSAISIDALGGCVGKITQ
F9ZW07_METMM/8-202TWLTAFSIIGVSFNALAYGL----FGLYVYPLLSVPAALVFSLPLVRLAGAGLAKILPK-DETSAVLLETLVGRTALVIN
Q3SGS5_THIDA/10-199LFLTLFSLLGFALQGVAAAV----LGQALPALAASPLALVGTLPATRAVGFTLSRAMPR-DESAAIAASSFVGRTAVVTA
Q8EH54_SHEON/10-209LALTSFAIAGYLVNYISLMV----SATLLPQLFTLPIAVVGSALSCRYLGRMLADLLPK-NESTAISLDDLSGYVGTITL
YQIJ_ECOLI/7-203LLAGFFGLIGILLQHACIMV----WQSPLSNLFVVPVSLLFTIIAVHYTGKIVAPWIPR-DHSSAITEEEYIGSMALITG
Q8ZLY8_SALTY/7-203LLAGYFGLFGILIQHGGIML----WQAPLSNLLLVPLSIVLSVFAVHYSGKILAPWLPR-DESSALREEEFIGGMAIITG
A3QBG8_SHELP/8-207LALTSFAIAGFAINYLAISF----HG.ALPAPLSIPLAIVLGAFSCRILGARLANLLPK-NETSAVSVDELSGLVGVVTL
C5ATC6_METEA/15-212LALAVFALVGFVVQGLAAAV----IA.PLPALLAVPVAGAATLPALRVSTKAIARLIPR-DESYVVSADDLIGATAEVTL
W0A7V1_9SPHN/12-199AFLAAFGLVGLAGQQLAQEL----TGTLVSPWLAIPAAAAAALPVTAAGSRLLARVLPQ-DETTAIDVATLVGRTGQIVV
Q89LS4_BRADU/12-206LALGAFSITGFLIQDVARMV----AG.PMPATVASIGAVAVSVPLVRAASRGIARVIPK-DESYVVGLGDLVGRVGEVVI
B8CU10_SHEPW/9-204LALVSFAIAGLSVNYFSLSW----FNSLLTQSVSLPISLMLMALSCHFLGGRLASILPK-NESSAVSVEDLNGCVGTLTI
F2GCT2_ALTMD/9-203VLLTVFGLSGLLINGLSATV----LSVTPPSLISVPLAFLVGLFITAKTVHIISSLLPT-IESSAVNSDEFVGSVAEITI
Q2K5I3_RHIEC/8-199MALGFFAIAGFAMQAVAGAF----WA.PLPAAVAAIPALVLTFPMVRASSRTVARIVPH-DETYAVDLDTLVGRTAEVSL

PF01957

A9CFM6_AGRT5/13-153VSLFFWEA................AFWAWQLQLVLFAALSVVFALLGRRYFGRNHATSD.EPFLNQREASLVGRTATLQ.
Q9Y9Y8_AERPE/348-492ILLPIRGEGFAVGESYA.......KTLLYTTYALGATMGGLTAFVVYKV....VKAKRA.P..Q..TLWKLKGAVGEAV.
Q8ZYJ1_PYRAE/276-427LSAYPANFFSGELIHIKD.....WWLIQLGLYIDIAIFLGFLSFVIYKIIILYKQRPPS.EFL.....TSLKGVEGVAI.
Q9HJ87_THEAC/279-427FLLASPYYSSNPGYSPSP.....FTTFDLLTSILIVIVAGFLAFYIRRIVRTFKFRGKW.TGA.....ESLIGKMGYA..
O28493_ARCFU/290-429LILFNEPLMPESFYDAF.......PKFVAGMGIGLGGIMTFMIIKIAQI....RKKKSS.V.......GEVVGEKGEV..
Q8U0Q2_PYRFU/295-442ILLFGGGNVE...YLVSKDVFSQLRLIIIILGVIIALFFAFGMAAVIRA....HRRKAA.TGK.....EEMIGSEGTV..
Q9HTX9_PSEAE/12-149LGALL...................PGLAWPWQVGLFVLLSGLVAALHRRRRRKAGSVEE.TPGLQRRGDDLFGRTFPLH.
Q8P6T7_XANCP/7-144LVLAV...................PGTSVLLQIVAFVVLSFVAIQVYRTWFRGKGRQSD.RPLLNRRAEQLIGRSVLLD.
Q9KD63_BACHD/294-444LLASFSTAWMLVSLGIS.......AVVTTVVAIITFRYFGSRGP.WKKMILTESTSSEK.GYITNETRQELVGLIGQS..
Q9CME2_PASMU/11-149VMALI...................PSLSLTVLAISYAILAIILSVSWWKYQHGQDKSDQLHSSLNQRDHAMLGTRGTVQ.
Q92UL2_RHIME/331-469AILFDTDMPG...LQVS.......WPALSGIAIASLAFSLLVARLALVS....RRHKVA.TGA.....EEMIGISGKV..
Q8KE94_CHLTE/294-434VMVFNQPELG...LVIN.......WWVFLPLFLSFSAGVLLLVFVVFRS....TRRKAI.SGR.....EGLVGETGTVE.
Q8RCN5_THETN/296-434LMLFSGNQMG...LTIN.......KGVVFATAFFMAAFVSFLLAAVIRA....QKRKVV.TGI.....EGMIGEFGTA..
Q9I667_PSEAE/298-439LILIDTEVPG...YGIP.......PGLVVALALLSAALIVGLLGMALRT....RRQAVV.SGT.....AGLVGSLATVAA
Q98H58_RHILO/13-153VSLLIWDA................AIWTWQVQVLAFLALSLVSAYVGKKLMGGRDQPTD.QPLLNRRGAQMVGRMATLA.
P71767_MYCTU/6-144LLAWPM..................WADGAVFLLVSVLLLVLVRPAVRRRLTQTKGVQLG.I.......EALEGKKAVVL.
Q98JI0_RHILO/328-465AMLLRVEGPG...FAMS.......WAVIGPAAALTLGLALLTGTYVWAA....RKNPPR.VGG.....DAMRGLPVEI..
Q8Y187_RALSO/320-464VMLIDTQTPG...YGVP.......IPVIVGLAFVSLTVILALSSLAVRA....RRRPKV.SGG.....DTLIGMTGEVVD
Q8TS89_METAC/290-434IFLVPLGSENIYTPEFR.......RLMILTIVTPTIVFGIFLVFAIYKVAETRKKKPVI.........GAIIGDTARTI.
Q8NQA4_CORGL/8-145IGVPV...................WAEFVTFAVASAALLMFIRPAIRKRLLKPKVLDSS.P.......RALVGHRAEVL.
Q97K68_CLOAB/7-143LGAP....................ITVQIVLFAIISIALLSVGYPLSKKLLNRTVRKTP.LME.....EKYIGREVKAE.
Q9CBM4_MYCLE/6-143LTDWPI..................WVDGTVFLIVSVLLLTLVRPAV.RRLTPALGTQLG.I.......KALEGKAALVL.
O67682_AQUAE/286-425LFLVEEGSPYGEIP..........KQLIISVSIFSAIFFLGVGYLGLKA....QKRKKL.TGI.....EGMIGEEGEAI.
Q2K1C3_RHIEC/306-441TILFDTDIPG...LEVS.......RPLLGAIAVATLAFSLVVARLAFTS....RLRQVT.TGA.....EEMIGISGRV..
Q2YIT1_BRUA2/13-150LAFLLSST................AGFGWQLQTVIFLVLAIVFTLAGRRFFGSKSNDTG.EPLLNRRGEQLVGQRATLT.

PF07290

F5ZCI8_ALTSS/9-205GIA---SKGNPAEAKFTDDYSQPHYVLVEPFEDNELFKQGERVILV.KKTTHSWLATRY-
Q07X14_SHEFN/9-209GRA---IKGMPTEAVVRDTFGQKHYVLVEPEHDDVEFLPGVDVVLI.AHQGKVWTAT..-
F9ZW07_METMM/8-202GTA---RVNYPAQAKVKNEHGQTFYVRVEPEQETQTFSAGQSVLLIKQISGTRFLAIAN-
Q3SGS5_THIDA/10-199GEA---RPGKSAEARFQDEYGQTHYVMVEPAADSPNLGAGERVLLLRELSAGRYQATPN-
Q8EH54_SHEON/10-209GCA---IKGMPSEAVVRDKHQQKHYVLVEPETSGIEFASGTQVVLL.KREGRVWSATRF-
YQIJ_ECOLI/7-203HQA---TSGNPCEGKLTDQFGQIHYLLLEPEE.GKIFTKGDKVLIICRLSATRYLAENN-
Q8ZLY8_SALTY/7-203HAA---VAGTPCEGKFTDKFGQIHYLLLEPEK.GKEFKKGDKVLIVCRLSATRYLAERT-
A3QBG8_SHELP/8-207GCA---RKGFPSEAVVKDAYQQKHYVLVEPELAGEAFSQGTSVVLL.NRNGQVWSVVQF-
C5ATC6_METEA/15-212GPL---DQGLPGQVRALDRHGNTHFLRTRAAPGAPAMEAGARVLIV.DRADAV......-
W0A7V1_9SPHN/12-199GTA---RRGAPARARVRDEHGQSHYVLVEPDNDGQAIGEGETVLLV.RREANLFRAIVY-
Q89LS4_BRADU/12-206GPL---DQGPPGRVSVADVHGNRHFVWAVAAPASGPLEQGTMVLLV.DRAGTRFVAVKA-
B8CU10_SHEPW/9-204GKA---VLGNPSEALVKDDYMQKHYVLVEPDEDGVEFLTGTQVVLL.KRKGRVWSAAK.-
F2GCT2_ALTMD/9-203GKA---SRGNPAEAKFTDCYSQPHFVLVEPFEEEELFSQGERVILI.QKNKHSWLATRY-
Q2K5I3_RHIEC/8-199GLL---DQGLPGRVRVKDQHGNWHVLRARAAKGQDPLKVGRQVLLV.DRKADVFIAIPA-

PF01957

A9CFM6_AGRT5/13-153.EP...IVEGRGRIRLDDT-----WWPVNGED....LPAGTRVRIA-SARGRTLTIEPID
Q9Y9Y8_AERPE/348-492DDI...PEGGTGFILVEGE-----YWKAKAITP...VARGDKVVVV-DKEGPYLVVKKAE
Q8ZYJ1_PYRAE/276-427DDI...GPESPGFVKVFGE-----YWRAVSDTP...VRKGCRIRVV-ETIGDMLKVEPLQ
Q9HJ87_THEAC/279-427.VE...GIDEKGWVSVDGI-----EWQARSSNGS.RIPKGSRVKIV-GRDGLILIVEKQE
O28493_ARCFU/290-429.LE...FSNGRGFARVRGE-----IWKVVSDEE...LEKGDEVEVI-AREGLTLRVRKIG
Q8U0Q2_PYRFU/295-442.VE...ELNPEGMIKVRGE-----LWKARSKDGE.KIEKGEKVKVV-GMEGLTLIVVRKK
Q9HTX9_PSEAE/12-149.RA...IVGGLGELRVEDA-----SWLVSGPD....LPRGALVRVT-GQDGALLHVEPAA
Q8P6T7_XANCP/7-144.QA...IVDGRGRAKVDDA-----FWVVSGPD....LPAGALVRIV-AVDGMTLQVQPNT
Q9KD63_BACHD/294-444.LT...PLRPSGSGLFGEE-----RLDVVSEGG..YIEQGRKIKVV-STSGSRIVVRETD
Q9CME2_PASMU/11-149.EI...AANGIGRGHFGDT-----TWRIQGTD....LQVGDLVEVH-QVDGITLKVKKVN
Q92UL2_RHIME/331-469.DS...WAGADGYVIAHGE-----RWRAVSSES...LGPGEDVMVV-GREGLTLKVARNA
Q8KE94_CHLTE/294-434RAI...GEGKDGKVFVHGE-----LWDASANGL...IPAGSQVTVT-GIEGMRLMVKQNS
Q8RCN5_THETN/296-434.VT...DIAPKGTVLVEGE-----RWQAVSKEP...IKKGEKVVII-GVEGLTLKVQKVK
Q9I667_PSEAE/298-439VDS...EQPCAGWVLLQGE-----RWRVLAARP...LAVGQPVWVL-ARKGLLLEVALAD
Q98H58_RHILO/13-153.EP...IKDGRGRIKLGDT-----LWRVSGPD....LPAGTQVRVT-SAADTDLELTVER
P71767_MYCTU/6-144.GR...VARDGGQVKLDGQ-----VWTARPLNDGDVFEPGDSVTVV-QIDGATAVVFKDV
Q98JI0_RHILO/328-465.LD...WQGGEGHVLALGE-----RWRAKAAEP...IVAGDSVEVT-DISDLVLTVRRRD
Q8Y187_RALSO/320-464VDTPEADADSDGWAHIRGE-----RWRVRCDAG...ITRGDRVRVI-ARHGLTLMVEPVA
Q8TS89_METAC/290-434DPI...GPKNPGFVRYKGE-----YWQAKAEEE...IGAEEEVEIT-GKEMEVLVVKRKI
Q8NQA4_CORGL/8-145.ED...VGATSGQVRLDGS-----IWSARSMDPTHTFAEGEIVSVI-DIQGTTAIVWKEA
Q97K68_CLOAB/7-143.AD...MEVGNSKLKVDGI-----YWTVKNVGE..AIKKGDCFIIT-GIQGNKLLIRKKG
Q9CBM4_MYCLE/6-143.DR...VARNEGQVKLDGQ-----VWTARTLSDDDVYEAGESVIVV-HIDGATAMVFRNG
O67682_AQUAE/286-425.VD...FKNGRGKVFVHGE-----IWDAVSEDD...IKKGDTVKVV-GAKGLKLIVKKSS
Q2K1C3_RHIEC/306-441.ES...WTGLTGYVIAHGE-----RWKAVSAEP...LVAGDPVRVT-GRNGLALEVAS..
Q2YIT1_BRUA2/13-150.EP...IVNGHGRIHINDT-----TWRVKGPD....LPAGTEIRIV-AFDPVSLEIE...

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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