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295  structures 7784  species 15  interactions 28518  sequences 210  architectures

Clan: ATP_synthase (CL0255)


ATP synthase F0 subunit Add an annotation

This clan contains subunits of the F0 complex of ATP-synthase. The F0 complex is the non-catalytic unit of ATPase and is involved in proton translocation across membranes.

This clan contains 13 families and the total number of domains in the clan is 28518. The clan was built by J Mistry.

Literature references

  1. Cross RL, Muller V; , FEBS Lett. 2004;576:1-4.: The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio. PUBMED:15473999 EPMC:15473999
  2. Rappas M, Niwa H, Zhang X; , Curr Protein Pept Sci. 2004;5:89-105.: Mechanisms of ATPases--a multi-disciplinary approach. PUBMED:15078220 EPMC:15078220


This clan contains the following 13 member families:

ATP-synt_8 ATP-synt_B FliH Fun_ATP-synt_8 HrpE Mt_ATP-synt_B NolV OSCP V-ATPase_G V-ATPase_G_2 vATP-synt_E Yae1_N YMF19

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ATP-synt_B (PF00430) 8697 (30.5%) View
OSCP (PF00213) 8249 (28.9%) View
FliH (PF02108) 2950 (10.3%) View
vATP-synt_E (PF01991) 2810 (9.9%) View
Yae1_N (PF09811) 2126 (7.5%) View
V-ATPase_G (PF03179) 1780 (6.2%) View
Mt_ATP-synt_B (PF05405) 1302 (4.6%) View
YMF19 (PF02326) 121 (0.4%) View
Fun_ATP-synt_8 (PF05933) 115 (0.4%) View
V-ATPase_G_2 (PF16999) 104 (0.4%) View
ATP-synt_8 (PF00895) 101 (0.4%) View
HrpE (PF06188) 91 (0.3%) View
NolV (PF06635) 72 (0.3%) View
Total: 13 Total: 28518 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 15 interactions for this clan. More...

Interacting families
ATP-synt_ab vATP-synt_E
ATP-synt_ab_N Mt_ATP-synt_B
Mt_ATP-synt_B ATP-synt_F6
Mt_ATP-synt_D Mt_ATP-synt_B
OSCP ATP-synt_F6
V-ATPase_C V-ATPase_G
V-ATPase_G vATP-synt_E
vATP-synt_E vATP-synt_E


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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