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1152  structures 5325  species 35  interactions 146995  sequences 1790  architectures

Clan: Acetyltrans (CL0257)


N-acetyltransferase like Add an annotation

This clan contains families related to N-acetyltransferases. N-acetyltransferases catalyse the transfer of acetyl groups from acetyl-CoA to arylamines.

This clan contains 39 families and the total number of domains in the clan is 146995. The clan was built by J Mistry.

Literature references

  1. Chinenov Y; , Trends Biochem Sci 2002;27:115-117.: A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity?. PUBMED:11893502 EPMC:11893502
  2. Kelley M, Vessey DA; , Biochem J 1992;288:315-317.: Structural comparison between the mitochondrial aralkyl-CoA and arylacetyl-CoA N-acyltransferases. PUBMED:1445276 EPMC:1445276


This clan contains the following 39 member families:

Acetyltransf_1 Acetyltransf_10 Acetyltransf_13 Acetyltransf_15 Acetyltransf_16 Acetyltransf_3 Acetyltransf_4 Acetyltransf_5 Acetyltransf_6 Acetyltransf_7 Acetyltransf_8 Acetyltransf_9 Acetyltransf_CG AstA ATE_C ATE_N Autoind_synth DUF1122 DUF1248 DUF1999 DUF2156 DUF3749 FemAB FemAB_like FR47 Gly_acyl_tr_C GNAT_acetyltr_2 GNAT_acetyltran HAT_KAT11 HlyC Leu_Phe_trans MCD Mig-14 MOZ_SAS NAT NMT NMT_C NodA ODC_AZ

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Acetyltransf_1 (PF00583) 63111 (42.9%) View
Acetyltransf_3 (PF13302) 21839 (14.9%) View
Acetyltransf_10 (PF13673) 13861 (9.4%) View
Acetyltransf_7 (PF13508) 6019 (4.1%) View
Acetyltransf_9 (PF13527) 3066 (2.1%) View
Acetyltransf_6 (PF13480) 2962 (2.0%) View
Acetyltransf_4 (PF13420) 2809 (1.9%) View
MOZ_SAS (PF01853) 2783 (1.9%) View
Acetyltransf_CG (PF14542) 2569 (1.7%) View
DUF2156 (PF09924) 2440 (1.7%) View
FemAB (PF02388) 2044 (1.4%) View
ATE_C (PF04377) 2030 (1.4%) View
Acetyltransf_5 (PF13444) 1880 (1.3%) View
ATE_N (PF04376) 1874 (1.3%) View
Leu_Phe_trans (PF03588) 1868 (1.3%) View
Acetyltransf_8 (PF13523) 1648 (1.1%) View
FR47 (PF08445) 1647 (1.1%) View
GNAT_acetyltr_2 (PF13718) 1642 (1.1%) View
FemAB_like (PF04339) 1338 (0.9%) View
HAT_KAT11 (PF08214) 1201 (0.8%) View
Pfam family Num. domains Alignment
NMT_C (PF02799) 1087 (0.7%) View
NMT (PF01233) 1084 (0.7%) View
NAT (PF04768) 1006 (0.7%) View
MCD (PF05292) 830 (0.6%) View
Acetyltransf_13 (PF13880) 750 (0.5%) View
AstA (PF04958) 730 (0.5%) View
ODC_AZ (PF02100) 622 (0.4%) View
Autoind_synth (PF00765) 595 (0.4%) View
GNAT_acetyltran (PF12746) 475 (0.3%) View
Acetyltransf_16 (PF05301) 385 (0.3%) View
Gly_acyl_tr_C (PF08444) 237 (0.2%) View
DUF3749 (PF12568) 148 (0.1%) View
HlyC (PF02794) 142 (0.1%) View
Mig-14 (PF07395) 82 (0.1%) View
DUF1248 (PF06852) 76 (0.1%) View
NodA (PF02474) 58 (0.0%) View
DUF1122 (PF06557) 24 (0.0%) View
Acetyltransf_15 (PF17013) 18 (0.0%) View
DUF1999 (PF09390) 15 (0.0%) View
Total: 39 Total: 146995 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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