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25  structures 6541  species 6  interactions 14776  sequences 79  architectures

Clan: Trigger_C (CL0262)


Trigger factor/SurA domain Add an annotation

This helical domain is found in two families of chaperones. It is found at the N terminus of the SurA proteins and at the C-terminus of the trigger factors where presumably it shares a common but as yet unknown function.

This clan contains 4 families and the total number of domains in the clan is 14776. The clan was built by A Bateman.

Literature references

  1. Ferbitz L, Maier T, Patzelt H, Bukau B, Deuerling E, Ban N; , Nature. 2004;431:590-596.: Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins. PUBMED:15334087 EPMC:15334087


This clan contains the following 4 member families:

SurA_N SurA_N_2 SurA_N_3 Trigger_C

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Trigger_C (PF05698) 6648 (45.0%) View
SurA_N_3 (PF13624) 5052 (34.2%) View
SurA_N (PF09312) 2015 (13.6%) View
SurA_N_2 (PF13623) 1061 (7.2%) View
Total: 4 Total: 14776 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 6 interactions for this clan. More...

Interacting families
FKBP_C Trigger_C
Rotamase SurA_N
SurA_N Rotamase
Trigger_C Ribosomal_S7
Trigger_N Trigger_C


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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