Sequence alignment for CL0262

PF13623

A0A015V3F2_BACFG/4-147-LQNIRS..K----------GPLLVIVIGLALFAFIA.GDA.WKVLQPH.QSHD.VGEVNGE-TLSAQDYQN-----MVE
D3HY39_9BACT/4-150-LGKIRS..R----------GLILICIIGFGLFAFIAEELF.RSCESSRNDQRQQVGEVLGE-KISVQDFQK-----LLD
D3II58_9BACT/4-150-LGKIRS..R----------GMILIGIIGLGLLAFIAEEAF.RSCEATRNNQRQQVGEVNGE-KISVQEFQK-----MVD
D9RVL8_PREMB/4-150-LGKIRS..K----------GGILVGAIGLALFAFLA.GDAARSCDGIKGEARQQIGEILGK-KISVQDYQK-----LID
D1XVV4_9BACT/4-150-LGKIRS..K----------GALLMIVIGLGLLGFLVEEGA.RSCSGLKAEQHSQVGEILGE-KISNQDFQK-----LIE
C6YVX2_9GAMM/2-125-LQSFNDRLK----------GPFTWIIIISISFIFVI.SGM.TFFFTNIGSSRSYVAKVGDN-EIGLQQFQQ-----YAQ

PF09312

SURA_AROAE/35-152-VDHI--------------------------------------------------AAVVNNE-VITARELRE-----RVE
SURA_VIBVY/24-141-LDKV--------------------------------------------------AVIVNDG-VILQSDIDT-----ATK
SURA_RALSO/87-204-VDEV--------------------------------------------------VAVVNTD-IITRRELLD-----RAD
SURA_CHRSD/29-146-LDRI--------------------------------------------------VAVVNKD-AIMQSRLED-----RVT
SURA_HAHCH/34-151-LDRV--------------------------------------------------VAVVNDD-IVLYSELQD-----RAS
SURA_NITMU/36-153-IDHI--------------------------------------------------VAVVNEN-VITRHELDE-----MLG
SURA_NITOC/23-140-LDRI--------------------------------------------------VAVVNED-IVLESELEQ-----MVR
SURA_THIDA/35-152-LNHI--------------------------------------------------VAVVNDE-VITRQELAK-----RYD
C1DIW7_AZOVD/32-149-LDRI--------------------------------------------------VAIIDND-VVMQTQLDR-----RLR
SURA_VIBF1/27-144-LDRV--------------------------------------------------VAIVDEG-VVLQSDIDT-----SLK
SURA_METCA/30-147-VDRI--------------------------------------------------VAVVDDG-VILESELVR-----KVD
SURA_XANCP/31-148-LDRI--------------------------------------------------AAIVDED-VVLQSELDR-----AVR
F2KM44_PSEBN/30-147-IDKV--------------------------------------------------VAIVDND-VVMQSQLDQ-----RVH
SURA_YERPE/25-142-VDKV--------------------------------------------------AAVVDNG-VVLQSDIDG-----LLQ
SURA_SALTY/25-142-VDKV--------------------------------------------------AAVVNNG-VVLESDVDG-----LMQ
SURA_VIBPA/24-141-LDKV--------------------------------------------------AVIVNDG-VILQSDINT-----AMK
SURA_XYLFA/33-150-LDRI--------------------------------------------------VAVVDDN-VVLKSELDR-----AIH

PF13624

B7TX43_PSEFL/1-165MLQNIRD..N..S....QGWIAKTIIGIIVALMAFT..GIEAI.FQASGNNK.QDVAKVNGE-EITQTELSQ.....AVD
D3SMV5_THEAH/1-156MFSFIQR..H..R....K..FLVVTVSVVSFAFFLWLFLAGSV.QDILRGKR.ACVAVVNGT-CISLRDYRM.....ELL
B4U8V8_HYDS0/1-151MFEFIRK..H..K....E..TFAILSGIVTAAFFLWNFAAGNI.TSLFHSSE.NCIAKANGD-CISIADFRR.....VAM
B5EQ33_ACIF5/1-165MMETFRNFGR..S....W..VAKSLMVLIALSFVLW..GVSGYLFSGH.STS.SVVATVDGQ-KISDAAFQK.....RMK
E6TYN9_BACCJ/1-153MFKYFKF..N..N....S..IFIISIAVLLIL.ILAPFNKGKM.EEQV.EID.AVVATVNGE-NIIYKDVIKVKNSMRLK
C7MZH2_SACVD/1-146MIRTIRR..YPSR....R..SFGVVLTAVTALL.LA.....SC.GSDP.AQA.RSAAVVGDH-VIQLDEVQA.....EVR
A3EPT2_9BACT/1-171MLEWIRK..V..AVERPK..VLGTLMILVGAIFVVS.MGWWGF.SAYK.SGKPGIVARINGT-PLYATEFSR.....DYE
C6HWQ2_9BACT/1-170MLEWIRR..E..AVERPK..VIGVLILLTGGIFVLS.MGWWGF.SQSGSSGG.DVVAKVDGV-PIKAKDYSR.....DYL
B5YGW7_THEYD/1-157MIKTLRK..N..A....K..YFYFLFFLVIITFVFW..GVGTV.DK...PKV.EYVADVDGQ-KISAERFWR.....NYE

PF05698

TIG_BORBU/272-432TLDDLKN----------------------FIRSSLL.NIVEEKKETLKLNKFFSTISEKLEI.DIPHSMIEA-----EIE
TIG_RHOCB/265-420DLEALKG----------------------QVASRLE.AEYKGASRAILKRALLDILDAQVKF.DLPPSLVEA-----EAG
TIG_TREPA/266-420TLDDLTR----------------------SVRQNLA.EALEAALHEYKRRQLLRILVRENPF.SLPESLVVG-----EME
TIG_CHLTR/273-432SLEDLKK----------------------KLRIQLE.NQAKEAQHQKRFSDAEDALAQLIDF.DLPESLLQE-----REE
TIG_CAUCR/268-426DLAALTE----------------------LLKSNLA.GRYDNSSRFKLKRALLDVLDTKHDF.PLPPRMVDA-----EFA
TIG_HAEIN/262-413SVADLRA----------------------EIRKNME.RELKNALVSRVKQQVINGLIEQNPI.DVPVSAVEE-----EIN
TIG_HELPY/268-427TLKLLKE----------------------RVEGQLFLENKARLYNEELKEKLIENLDEKIVF.DLPKTIIEQ-----EMD
TIG_BUCAI/263-415TIQTDYQ----------------------TIKNNLH.SQINIITDKYLENQIIQKIVEKNIL.LLPPLLFQK-----EIK
TIG_PASMU/262-413TVDDLRN----------------------EIRKNMQ.RELKNALTAKVKGQVIDGLLAQNAI.DVPASAVEQ-----EIE
TIG_MYCPN/275-440SLKEFKT----------------------YFHKLVS.AKKLEITLQENSVKIRQFFLANTTLPYIPDSLIKL-----ESD
TIG_BACSU/264-422TLAELTE----------------------KTKKRLE.EAKENEADAKLREELVLKASENAEI.DVPQAMVDT-----ELD
TIG_CAMJE/268-427SVEVLDE----------------------KLKEQIKNEKLFKLVNDELKGKFADALIEKYNF.DLPKGIVEQ-----ETD
TIG_SYNY3/277-441TMAELKA----------------------DLEKQFQ.EQAKQRTDDNIKAAIKKKLGELFTG.DLPETMIKQ-----ECD
TIG_CHLTE/257-411KVEDFRN----------------------DIRLQLQ.AHFSDKSEYDLLEAISSKLIEEHPV.PTPSAMVAH-----FQN
TIG_CORGL/258-419TIEELRE----------------------STVSDVE.AKQKNEQAAAIRDEVLAAALGEADF.ALPQSIVDE-----QAH
TIG_FUSNN/261-426SLDELKA----------------------KTKEETT.KRENDRIENEYVSALLDKLMETTTI.DVPVSMVQA-----EIQ
TIG_THETN/263-423TLEELKQ----------------------DIRKKLE.EKNKREAENEMKEKAVMKVVENAKV.DIPDVMVER-----QID
TIG_ARATH/379-538TLKEVEE----------------------TLAKRCQ.EMEQEAKEQATDNAILEQIRKMVEV.EIPQSLFEE-----QGR
TIG_AGRT5/268-426SAEKLKE----------------------IVKGQIE.SQFGNVTRQKVKRQILDQLDEMYKF.DTPAGLVDA-----EFD
TIG_CLOPE/263-425TLEELKA----------------------DLKEKAV.KANELRAKREMEEKVINAVVDNAKV.EIPEAMINR-----EVE
TIG_RALSO/273-427SLDKMRA----------------------DIRENLE.REVKRRTHALLKDQVMDALLKVAEL.DVPKSLIEQ-----DQE
TIG_LISMO/264-422TLDELKE----------------------KISKRLQ.EAKEESVAQAKQEEVIAKAVENAEV.DIPHAMVHH-----EAD
TIG_NOSS1/279-432TLEALRA----------------------SLAERYQ.KEAEDKTKNNQQEALLGELVKHIEV.DLPETLIEK-----EVD
TIG_SYNE7/273-427TIEELKT----------------------ALTERFQ.AEHESEVKASKRDAILTALADQLDV.EIPESLLQR-----EIS
TIG_CLOAB/264-425TLDEVKA----------------------DIRSKME.KANEEKAKIEFEDKVVDAAVENAKI.EIPEVMVKN-----ETD
TIG_RHILO/268-427SLERLRE----------------------IVRGQIE.NQFGSMTRQKVKRQLLDQLDAAYSF.EAPSKLIDA-----EFN
TIG_MYCPU/270-429NLEQLKE----------------------YLRPSIE.HKLLEDSLTEFKNEAFNKIKELNDI.KIPRGLLLE-----EMT
TIG_MYCLE/258-419TMAELRA----------------------NLGDQVR.KAKYAQQAEKIRDAAVDALLERVDV.PLPEGIVQA-----QFN
TIG_LACLA/264-422TLDELKA----------------------KFRKELE.ESKAEAYNDAVETAAIEAAVANAEIKEIPEEMIHE-----EVH
TIG_STRCO/258-420TLEELQA----------------------DSRKRLA.NMKQYDQATQAQERVLDKLLELVEV.PVPEKLLED-----EIN
TIG_PSEAE/262-412GLDGFRA----------------------EVQKNME.RELRQAIKSKVKNQVMEGLLQANPI.EVPKALIGN-----EVN
TIG_BACHD/264-425SLDELKK----------------------KLREKLE.KDRAHEADHEKRDTLIQKASENATI.DIPEAMINT-----ELD
TIG_VIBCH/262-413GVDALKA----------------------EVRKNME.RELKQAIKARIKEQAIEGLVKENEI.QVPSALIDQ-----EIN
TIG_XYLFA/259-414KLEDFRA----------------------DIRANLE.RELKGALVSHLRREVGEQLIAAYAHVEMPPRLVEK-----EAR
TIG_UREPA/274-434TVQELKD----------------------YIHNQIV.LAKQEKNSERAWLEIAQQLLAKAKITPIPQSLIDR-----EVS
TIG_DEIRA/249-416SMDKLRT----------------------DLREELE.RRAQQEGDNLRREELVGHLVEGMTV.EIPQALIDR-----RRE
TIG_THEMA/247-403TLEQLKE----------------------SLKKEGK.EIYDVEMKESMREQLLEKLPEIVEI.EISDRTLEI-----LVN
C4YVZ7_9RICK/261-415SLEELRT----------------------HFTKQIE.NESEEAINTIMKMNLFDKLEKLLDF.DVPESLLEQ-----EKN
G8AKT7_AZOBR/262-419SLEKLRE----------------------AVGDRIK.GEYANVSRLRVKRQLLDKLAEAHSF.EVPPGMVDV-----EFE
TIG_STRP1/264-421TLEDLKV----------------------KYRKELE.AAQETAYDDAVEGAAIELAVANAEIVDLPEEMIHE-----EVN
TIG_SALTY/262-412SVAGLRA----------------------EVRKNME.RELKGAVRNRVKSQAIEGLVKANDI.DVPSALIDS-----EID
TIG_MYCTU/258-418SIDELRA----------------------SLSDQVR.QAKRAQQAEQIRNATIDALLEQVDV.PLPESYVQA-----QFD
TIG_STAA8/264-420TVDEYKE----------------------NLRKRLA.EQKATDAENVEKEEAITKATDNTTI.DIPEAMVNT-----ELD
TIG_BRUA2/268-425SLERLRQ----------------------VVREQIE.SQYGQITRQKVKRQILDALDGDYQF.ETPQKLVDA-----EFN
TIG_STRR6/264-421TLADLKE----------------------KYRKELA.AAKEETYKDAVEGAAIDTAVENAEIVELPEEMIHE-----EVH
TIG_XANCP/260-413..EQFRA----------------------DIRTNLE.RELKGALMNRLRREVGEQLIAAYAHVEMPPRLVEN-----EAG
TIG_NEIMB/265-417.VAKMRE----------------------EVQKNVS.REVERRVNEQTKESVMNALLKAVEL.KAPVALVNE-----EAA

PF13623

A0A015V3F2_BACFG/4-147----E------Y----TEVIK------.F----------SSGM.SSLNDEQTN...QVKDE-----VWRSYVNNKLIEKE
D3HY39_9BACT/4-150----E------Y----QEVIK------MQ----------QGTE.TL...SEEQL.NQVKDM-----VWNTYVQSKLVEKE
D3II58_9BACT/4-150----E------Y----AEAIK------.M----------QQGQ.DN...LNDEQLNQVKDM-----VWTSYVQNKLVEKE
D9RVL8_PREMB/4-150----E------Y----QSAIK------.F----------TMQRDNL...TDQEL.KQVEDQ-----VWQQLVSNRVIEAD
D1XVV4_9BACT/4-150----E------Y----QSAIK------.L----------TMQR.DN...LSEEELNQVKDQ-----VWQQLVSNRVLEAD
C6YVX2_9GAMM/2-125----N------A----T....------..----------............TE...SQKRA-----VLDQMINQYLILAD

PF09312

SURA_AROAE/35-152----Q------A----IHQLN------RQ----------GTPQPPA---------DVLERQ-----LLERLVLERAQLQL
SURA_VIBVY/24-141----T------L----RANAK------KS----------GQALPDA---------DVLNEQ-----IVDKLIIDTLQTQE
SURA_RALSO/87-204----L------V----ERTLQ------SQ----------NRQVPVR---------ADLLGE-----VLEQLILERVQAQT
SURA_CHRSD/29-146----Q------V----RRQMA------SR----------NVPAPNE---------ADLRRQ-----VLDRMILEQIQLQM
SURA_HAHCH/34-151----R------I----KDKLR------QQ----------KTPLPPE---------AVLHEK-----VLDQLVLESIQMQM
SURA_NITMU/36-153----A------M----LKQLQ------KQ----------GVQPPPP---------AVLEKQ-----LLERIILNRVQLQL
SURA_NITOC/23-140----T------V----QDQLA------AQ----------GTSLPPG---------YVLERQ-----VLERLVMEQLQLQL
SURA_THIDA/35-152----E------V----VRNLS------RQ----------NTPLPPR---------NVLEKQ-----LLERMVTELALQQH
C1DIW7_AZOVD/32-149----E------V----EQTIA------KR----------GAQLPPR---------DQLVSQ-----VLERLILESIQLQM
SURA_VIBF1/27-144----T------V----KINAQ------EK----------GQPLPDE---------AVLREQ-----VLEKLIVDTIQSQQ
SURA_METCA/30-147----E------I----KRSLR------AS----------RASLPPD---------SVLVRQ-----VLERMIVDKIQIQM
SURA_XANCP/31-148----N------V----KSQYA------GR----------DNQLPPD---------DVLQRQ-----VLERLVLVKLQVGR
F2KM44_PSEBN/30-147----E------V----QQTIA------KR----------GGGQPPP---------GVLDQQ-----VLERLIVENLQLQI
SURA_YERPE/25-142----S------V----KMNAQ------QS----------GQQVPDD---------STLRHQ-----ILERLIMDNIQLQM
SURA_SALTY/25-142----S------V----KLNAG------QA----------GQQLPDD---------ATLRHQ-----ILERLIMDQIILQM
SURA_VIBPA/24-141----T------L----QANAR------QS----------GKSLPSA---------SVLKEQ-----VVEKLIIDTLQGQE
SURA_XYLFA/33-150----N------V----KSQYV------GH----------EGQLPPD---------EVLQRQ-----VLERLILIKLQVAR

PF13624

B7TX43_PSEFL/1-165....M......Q----RRQLM......QQLGKDFDASLLDEKL...---------..LRDA.....ALKGLIDRKLLLQG
D3SMV5_THEAH/1-156....P......Y----SQFLK......NEE.........MEGM...---------..IKEQ.....VLDSLIVRELLYQK
B4U8V8_HYDS0/1-151....G.......----....T......NQQ.........MTPI...---------..LKQE.....ILNSLIDDDLLYEQ
B5EQ33_ACIF5/1-165DALAR......Y----SHIFG......ATT.........AAKMAAD---------RSFGLE.....VLNGLIDNMLLGME
E6TYN9_BACCJ/1-153....K......Y----NDLTN......N...........NEDK...---------..LTEA.....AIEQRIIHRLLIQE
C7MZH2_SACVD/1-146....WLLDHAPQ----AQQAR......EQR.........RIDQ...---------..ISSE.....IVRSRVVHELLAVA
A3EPT2_9BACT/1-171....I......M----KNNYQRL.LLNGAL.........GKKILTE---------LNFPGL.....VLRNMIFRQLWIDE
C6HWQ2_9BACT/1-170IMKDN......Y----KRLLR......GDL.........GAKI...---------..LKDLNFPGLVLRNMIYRQLWIDE
B5YGW7_THEYD/1-157....E......I----RRFYREVFKDKAAE.........MEQG...---------..LKEK.....VLEDLINEEILLWL

PF05698

TIG_BORBU/272-432----I------A....FKDAK------RQN..KNNMSLEEFKSIFYS..SGYIGGDNLKDE-----ILGNLKSKLIMQKM
TIG_RHOCB/265-420----Q------I....AHQL.------.........WHEENPDHHGHDHGAVEPTEEHKTL-----AERRVRLGLLLAEL
TIG_TREPA/266-420----S------RWALVMRQF.------.............GVSLSGTPQNKLQFFQQWRPE-----VEEHLKQRVIVELL
TIG_CHLTR/273-432----L------L....SREKL------LNA......RLVKYCSDSELEEQKQALLEEAKAD-----ARKAVKLLFLTQKV
TIG_CAUCR/268-426----G------I....WQQVE------ADK.ARGGLPPEDA......EKTEDQLKDEYKKI-----AERRVRLGLVLAEI
TIG_HAEIN/262-413----V------L....RNQAA------QRF....GGNAQQ.........TAQLPRELFEAE-----ATRRVQVGLLFSEV
TIG_HELPY/268-427----L------L....FRNAL------YSM......QAEEVKSLQESQEKAKEKRESFRND-----ATKSVKITFIIDAL
TIG_BUCAI/263-415----N------L....YKQYT------KQY............QEENSNILEKKYHMSLDSE-----VKKRLYFQIIIEQI
TIG_PASMU/262-413----V------L....RGQAA------QRF....GGNKEQ.........AAQLPRELFEEQ-----AKRRVQVGLLLAEV
TIG_MYCPN/275-440----R------L....LRAQK------DQA.EQYKIPFERLLAASKL..SLEQLQQRNIKE-----ARDNVTFALVMKRI
TIG_BACSU/264-422----R------M....LKEFE------QRL.QMQGMNLELYTQFSGQ..DEAALKEQMKED-----AEKRVKSNLTLEAI
TIG_CAMJE/268-427----M------Q....MRAAF------NTF......SEKEIEELKASKEKYQEKRDSFKEE-----AQKSVKLTFIIDEL
TIG_SYNY3/277-441----R------L....VAQTA------MEL.ERMGLDVSQLFRQGDD..MLQTLKDNSRPE-----AIANLKTDLMIGAI
TIG_CHLTE/257-411----I------L....LENAK------RQV....GGQFPKGF.......DEREFFNAMKPN-----AEKHARWLLISQKI
TIG_CORGL/258-419----S------Q....LHQLL------GEL.AHDDAALNSLLEAQGT..TREEFDKKNVED-----AEKAVRTQLFLDTL
TIG_FUSNN/261-426----N------R....LKELE------YQL.SMQGFKMDDYLKMMGG..NVETFAAQLAPA-----AEKKVKIDLILDRI
TIG_THETN/263-423----L------S....LRDLD------YNL.RLQGLDLNTYLSITGK..TIQDLRKEMWEG-----ALNRVKTQLVIDKI
TIG_ARATH/379-538----Q------F....YGARL------LEIQGNMKLNEDQLASLSSQ.KAVNEFLETQRES-----ITNIIKQNIAVGDI
TIG_AGRT5/268-426----N------I....WRQIN------TDL.AQSGKTFADE......DTTEEEAREEYRKL-----AERRVRLGLVLSEI
TIG_CLOPE/263-425----N------M....VRDLE------MRL.GQQGLSLEQYYEFTGS..TEDKMKSYMKEN-----AERKVKTDLVMSAV
TIG_RALSO/273-427----R------L....VEMAR------RDL.EARGMPNVK.........NMPIPAEMFAQQ-----AERRVKLGLVLAEV
TIG_LISMO/264-422----H------L....MNHFA------QDL.QAQGLTPELYYQFTGQ..TEEAMHAQMEKD-----AEKRVKMNLVLEAI
TIG_NOSS1/279-432----A------M....LTQTA------MRL.SQQGLDVKKLFTQD....IIPQLRERSRPE-----AVERLKRSLGLQEV
TIG_SYNE7/273-427----A------M....INETA------SRL.SGQGMDVRKLFTEE....VLERLRENSKDE-----AEQRLRRTIALGEL
TIG_CLOAB/264-425----Q------M....LKELE------SRL.RYQGLDLKSYYEYTNS..SEEKVRDYMKET-----ADKRVRTKLVMEKI
TIG_RHILO/268-427----N------I....WAQVT------RDL.EAAGRTFADE......ETTEEEARAEYLRL-----AERRVRLGLVLAEI
TIG_MYCPU/270-429----A------I....NEKFN------ETL.KAQGLKRREYLEMTKL..SEEKVAEQVKKE-----AITKINEYLIFEQI
TIG_MYCLE/258-419----N------A....LHDAL------SGL.GHDEAKFAEVLAERGS..SREEFEAEARSA-----AERDVTRQLLLDVV
TIG_LACLA/264-422----R------A....MNEFL------GGM.QQQGISPEMYFQITGT..SEDDLHKQYEAD-----ADKRVRTNLVIEAI
TIG_STRCO/258-420----T------R....KHNLE------HHQLGQMGLDLEKYLELQGK..TAEEFETETREA-----AVKGIKTQFVLDEL
TIG_PSEAE/262-412----R------L....RVQAV------QQF....GGNIK..........PDQLPAELFEEQ-----AKRRVVLGLIVAEV
TIG_BACHD/264-425----R------M....TQEFE------QRL.QMQGMNLEMYFQFSGQ..TQEQLREQMKED-----AEKRVRVNLTLEAI
TIG_VIBCH/262-413----V------L....RQQAA------QRF....GGNVEA.........AAQLPRELFEEQ-----AKRRVVVGLLLGEV
TIG_XYLFA/259-414----L------M....LAKQI------EQI.RLSGRDPTG.........IPDDAHIGFMDA-----ACKRVLVGLLVGEI
TIG_UREPA/274-434----T------L....RQQVL------SQL.SQYKIELKQYLEFSKK..SEAQFQEDLIRQ-----AKETITLALLVDDI
TIG_DEIRA/249-416----G------M....MSEIQ------DDL.RRQGVQWKEYEAFMQEQGKLDEFEADLTKN-----AETRVRRDLALEQL
TIG_THEMA/247-403----E------A....INRLK------REG.........RYEQIVSSYESEEKFREELKER-----ILDDIKRDRVIEVL
C4YVZ7_9RICK/261-415----I------L....KSETD------KND......QDESL..LKDK..SSKEITEYYNKL-----ALRRVRIGLLLAEY
G8AKT7_AZOBR/262-419----G------I....WQRLQ------QEL..KNGTAGED....AGK..PEEELKTEYRGI-----AERRVRLGLLLSEI
TIG_STRP1/264-421----R------S....VNEFM------GNM.QRQGISPEMYFQLTGT..TQEDLHNQYSAE-----ADKRVKTHLVIEAI
TIG_SALTY/262-412----V------L....RRQAA------QRF....GGNEKQ.........ALELPRELFEEQ-----AKRRVVVGLLLGEV
TIG_MYCTU/258-418----S------V....LHSAL------SGL.NHDEARFNELLVEQGS..SRAAFDAEARTA-----SEKDVKRQLLLDAL
TIG_STAA8/264-420----R------M....VSEFA------QRI.QQQGLDLQTYFQISGQ..DETQLREQMKDD-----AEQRVKTNLTLTAI
TIG_BRUA2/268-425----N------I....WQQIN------FDL.QQAGRTFED....EET..TEEAAREEYRKL-----AERRVRLGLVLSEI
TIG_STRR6/264-421----R------S....VNEFL------GNL.QRQGINPDMYFQITGT..TQEDLHNQYQAE-----AESRTKTNLVIEAV
TIG_XANCP/260-413----S------M....LAQQV------DQM.RRSGRNPGE.........IPADAHQGFMDA-----AAKRVLVGLLVGEV
TIG_NEIMB/265-417----R------L....ANEMK------QNF.VNQGMADAA.........NLDLPLDMFKEQ-----AERRVSLGLILAKL

PF13623

A0A015V3F2_BACFG/4-147AKKLGITVSKAEIQSIINEGV-----NPLLQQT........P.F.RNPQTGAFDK---DMLKKFL-----------
D3HY39_9BACT/4-150AKELGLTVTDTELQDVLKAGT-----NPMLLQT........PFVNQQ..TGRFDA---ASLQKFL-----------
D3II58_9BACT/4-150AKELGLTVTDQEMQNVLNQGT-----NPMLMQT........PFVNQQ..TGRFDA---SSLKKFL-----------
D9RVL8_PREMB/4-150AEKVGLTVTEKEIQNVL....-----....NEGTNPMLVQTPFVNQQ..TGRFDV---NALKQFF-----------
D1XVV4_9BACT/4-150AKKVGLTVTEQEMQNVLNDGT-----NPALAQT........PFV.NQ.QTGRFDV---NALKQFI-----------
C6YVX2_9GAMM/2-125AQRHNIVVSKLALQSAI....-----....FTN........PMF.FD.KDGKFSA---DKLKQVV-----------

PF09312

SURA_AROAE/35-152ARETSLQVDEATLERAIARIA-----ESNRLTI--------AQLQAALEKDGVSW---SRFRDNIRTEILLTRLR-
SURA_VIBVY/24-141ADRIGVRIDDTRLNQAIEEIA-----RNNNQTI--------DELSAAIASEGVSY---EEFREQIRKEMAASEAR-
SURA_RALSO/87-204AKESGIRVSDADVDRAVESVA-----QRNNLSV--------SQLKSKLAQSGLAY---DKYREDLRQEILLARLR-
SURA_CHRSD/29-146AERANLSIDDTQLNATVRGIA-----EDNGMSM--------DEFADALEEDGMSL---ASMREQVRREMLLRQVQ-
SURA_HAHCH/34-151ADRGGIRVSDSQLNQTMQNIA-----KQNGMTL--------DQFQQALSEEGVTY---QSAREQIRREMIISRVQ-
SURA_NITMU/36-153ANETGLTVSDAELDQTLRRIA-----QENKMSL--------QEFDRALAEDGVSF---SKFRDEIRDEIILVRLK-
SURA_NITOC/23-140AARTGIQVGDETLNEALGRIA-----QDNGLTL--------SQFRNVLEQDGYDF---PAFRENIRKELIISQLH-
SURA_THIDA/35-152ARNTGVRADPTLVERALQRIA-----AQNKLDM--------AGLQAALEKEGQTL---DGMRNTIRNELLIARAR-
C1DIW7_AZOVD/32-149GSRAGIRIGDEELAQAMATIA-----QRNGLTL--------EQFQAALARDGLSF---DEAREQVRREMIISRVR-
SURA_VIBF1/27-144AEKMGIRIDDTRLEAALNDIA-----KENNMTL--------AQLQQKTAAQGLPY---ANFREQIRKEIAASEAR-
SURA_METCA/30-147AEKMGIQVDDDTLRMAVSQIA-----QRNNLTP--------DQFRRSLAREGIDY---GDFLDQVRSEIAMGRLR-
SURA_XANCP/31-148AEGSGIRVSDEELNRAIASIA-----QQNGTSV--------DGLRQKLAADGMGY---ADFRASVRDEIIVQRLR-
F2KM44_PSEBN/30-147GERSGIRITDEELNQAVGTIA-----QRNNMSI--------DQFRAALARDGLSY---EDARDQIRREMVISRVR-
SURA_YERPE/25-142AKKMGITITDQALDKAIADIA-----AQNRMTL--------AQMRSRLAADGLSY---DTYREQIRKEMLTSEVR-
SURA_SALTY/25-142GQKMGVKITDEQLDQAIANIA-----KQNNMTM--------DQMRSRLAYDGLNY---STYRNQIRKEMIISEVR-
SURA_VIBPA/24-141ADRIGVRIDDNRLNQAIAEIA-----RNNNQSV--------EELAASVQAEGLSY---PEFREQIRKEIAASEAR-
SURA_XYLFA/33-150AQTNGIRVSDDELNQAISSIA-----ENNKTSV--------DGLRQKLVAEGISF---PEFRQSVRDEITVHHLR-

PF13624

B7TX43_PSEFL/1-165AADSKFGFSEAALDQVILQTPEFQV.D.GKFNA--------ERFDQVVRQLGYSR---LQFRQMLTQEMLIGQVR-
D3SMV5_THEAH/1-156ALEMGFVASDEEVIDTIKSDPTFQE.G.GVFSA--------SKYREVLERNNLEP---AQYEEYLKKMLSIQKLV-
B4U8V8_HYDS0/1-151AKKEGFLVSDKEVADIISQDPSFQV.D.GKFNF--------DRYKAVLAEAGYTP---ETYESYIKKQLTIQKYT-
B5EQ33_ACIF5/1-165AGRLGLQVPDAALAKKIESIPAFQE.K.GAFSK--------NLYQKLLAANGMTP---AQFEDMLRESMRLEQLQ-
E6TYN9_BACCJ/1-153AQRLNIEVSDEEVAIQLQLIKEV......LPSD--------LTLEESLILQNYTE---DALLAEIKEQLMIERLL-
C7MZH2_SACVD/1-146EERENLRVDETKVDELIEA.....S.G.G....--------..VEEAARNIAVEP---SRVRDVARDQLLLEQLG-
A3EPT2_9BACT/1-171ANHLHLIVPDAVVVSEVSRIPFFQEGNPPVFSS--------KLYTQFLLETHQSA---KDFEQSIREDLLVQRAQ-
C6HWQ2_9BACT/1-170GKSLGIAVSDKTVVDEIAKIPFFQVGNPPVFSK--------DAYVTFLKETHQSA---QSFERSVRLDVLVQRAQ-
B5YGW7_THEYD/1-157AKKYEIEATDKEVQDAIVNDPRFMR.N.GIFQR--------DIYFQILKLNRLNP---AQYEASLKREITIGKTI-

PF05698

TIG_BORBU/272-432VDLDPIKVTESDVEDEMARQSK.NL-G..V.SY--------EEIKKFYEDQNLIS....YLKDDIKRERAKKKILE
TIG_RHOCB/265-420GRNEKIEVTDAEMTQAVLAAAR.QY-P..G.HE--------REFFEFVKGNAQMQ...QQIRAPLYEEKVIDFIVA
TIG_TREPA/266-420LKQEQVSVSAEEIETEYVRIAS.KT-G..S.KE--------ERVREYYAGEEKRR....ALCEGIRERKLCQKLLG
TIG_CHLTR/273-432FSEKGLSISREELQYMMDVCSRERF-G..GYPP--------KDISNEMIQELVLV.....ARDRLTYRKAIEAISS
TIG_CAUCR/268-426GRKNDVVVTDQELTDAIMREAR.QY-G..A.QA--------QQVFDMYRQRADLQ...AALRAPIYEDKVVDLIFG
TIG_HAEIN/262-413IKSNELKADEERAKAMIADIAS.AY-E....QP--------AEVVEYYSKNEELM...NNIRNVVLEEQAVDAVLA
TIG_HELPY/268-427AKEEKIGVHDNEVFQTLYYEAM.MT-G..Q.NP--------ENLIEQYRKNNMLA....AVKMAMIEDRVLAYLLD
TIG_BUCAI/263-415ILNNKLFADENNIQKLIKKISS.NY-K....NP--------MEIIKLYNKNKNLK...NTMKNIELERQAMLLLKK
TIG_PASMU/262-413IASHELKVDEARAKTMIEEIAS.AY-E....QP--------AEVVEYYSKNKELM...NNIRNVVLEEQAVDAVLA
TIG_MYCPN/275-440ADVEKIKVDNKKIHSEIESIIDVEY-P..FVNA--------ELKKQMFHNMEQQK...DFVESIILNRLTTTKIIE
TIG_BACSU/264-422AKAENLEVSDEEVDAELTKMAE.AY-N..M.PV--------ENIKQAI...GSTD....AMKEDLKVRKAIDFLVE
TIG_CAMJE/268-427AKLRKIEVNDQELIQAIYFEAY.RY-G..M.NP--------KEHLENYKKQGALP....AVKMALIEEKLFNDIFI
TIG_SYNY3/277-441AKEEKIQPTEAEVKERCDELRQ.EF-KGEKIDE--------SRLVNFVESSLTES....KVLDLLKEWADVELLPE
TIG_CHLTE/257-411AKENNLEVTDEDIKAFAEKEAE.KE-P..SLTV--------DQLLNTYLSTEFKD....YIIDTILKEKIYDVIKS
TIG_CORGL/258-419SEVEEPEVSQQELTDHILFTAQ.SY-G..M.DP--------NQFIGQLQQSGQIA....NLFSDVRRGKALAQAIC
TIG_FUSNN/261-426AKDNNFEATDEELNQRMEEIAK.MY-G..M.DV--------PALEEELKKNKNLENFKASVKYDIVMKKAIDEVVK
TIG_THETN/263-423AKVENIEATEEELENKLKELAE.SY-R..V.NL--------EEFKKSL.TESQIN....GIKEDIAYYKTIDFIFN
TIG_ARATH/379-538FKRENLEFSTDELVKEVENSIS...-.....EF--------KKHKQEFDEERVKD....QVQEILEGAKVLEWLKD
TIG_AGRT5/268-426GEKAGVEVTEEEMQRALFQQLQ.QF-P..G.QQ--------KEILDFFRNTPGAS...ASLRAPIFEEKVIDKLLT
TIG_CLOPE/263-425TEAEAIEATEEELKAKAEEVAK.MY-SNGA.ET--------EKMVDLL.LNAQRA....ALELDVKREKTLKMLFE
TIG_RALSO/273-427VKVNALEAKPEQIKAEIEEFAK.SY-E....DP--------KEVIRWYYGDQQRL...AEMEAYVLENNVVNFVCD
TIG_LISMO/264-422AEAENIEPTEEAIDEEISTLAE.KY-G..M.EK--------DAVRAAL...GDMS....ELKSDLKIRKAIDVLLD
TIG_NOSS1/279-432AKRESITVTPEEIQARVTELVQ.QY-P......--------...DEDIDAERLQT....IVENELLSEKIIDWLLA
TIG_SYNE7/273-427AKVTETQVDDEAVKARAAELLS.NY-P......--------..RPQEIDRDRLNT....VVREELLEDKLLEWFEA
TIG_CLOAB/264-425SEVEKVEATEEELKEKAKEMAQ.QY-T.NK.DL--------DKMAELV.LNSQRS....MIEQDVINGKVIDLLVE
TIG_RHILO/268-427GEKAGVTVSDEELQRGLFEQVR.RF-P..ANQQ--------QEAFEFYRSNPEAL...NALRAPMFEEKVVDHLLG
TIG_MYCPU/270-429KKAENVTISDDIIEDHYNIMAK.NY-N..I.EV--------DKIKEFIPVDKLKE......DPNLLNEQVILKLLE
TIG_MYCLE/258-419ADDQKIQVGQDDLNERLLATSQ.QY-G..V.DA--------QQLFGFLRENNRLS....SLVTDARRRLAVAAVVE
TIG_LACLA/264-422AAAENFTTSDEEVKAEIEDLAG.QY-N..M.PV--------EQVEKLL....PVD....MLKHDIAMKKAVEVIAT
TIG_STRCO/258-420VKQEKLNVSQEELTEHLMRRAA.SS-G..M.SP--------DQFAQAVVEQGQVP....LLVGEVARGKALAAVVE
TIG_PSEAE/262-412VKQHELKADEGRVREMIEEMAS.AY-Q....EP--------EQVVAWYFKNEPQL...NEVRSVVLEEQVVDTVLQ
TIG_BACHD/264-425ANQENLEASDEDVEKELEKMAE.MY-Q..R.SV--------DEIKSIFATQGGTD....GIKADLKIQKAVDFLVE
TIG_VIBCH/262-413IRTHELKADEEKVKALITEMAT.AY-E....DP--------SEVVSYYEQNQQLM...NNMRNVALEEQAVDAIIA
TIG_XYLFA/259-414AGRNRLRLDPMRVTETLHLIAS.TY-E....EP--------EEVFEMYRNDPKLM...EGVQSLVMEEQVIEWIAD
TIG_UREPA/274-434AETQNIVVSDEEVKERVAEMAK.LY-Q..G.EE--------QAVIEQLSKNPD......AVKEFLLHKKVVNYLID
TIG_DEIRA/249-416ATDLNAQVNEAEFNQTLMNLAQ.AN-G..M.NV--------QQLVQQLGQDGVQSYYISLLRERGLQRALAQLSGE
TIG_THEMA/247-403AQEKGISVNDEELEKEAEELAP.FW-G..I.SP--------DRAKSLVKARQDLR...EELRWAILKRKVLDLLLQ
C4YVZ7_9RICK/261-415AKSKNLQLEPDDLRKVIMQQAR.NF-P..G.QE--------NMIFDFYKNNPRAI...EGLKGPALEDKVVQYIF.
G8AKT7_AZOBR/262-419GRRNDIQVTQDEINRALIAEAR.RF-P..G.QE--------RQVFEFFKQNREAL...ENLRAPIFEDKVVDYILD
TIG_STRP1/264-421AKAEGFEATDSEIEQEINDLAT.EY-N..M.PA--------DQVRSLL....SAD....MLKHDIAMKKAVEVIT.
TIG_SALTY/262-412IRTNELKADEERVKGLIEEMAS.AY-E....DP--------KEVIEFYSKNKELM...DNMRNVALEEQAVEAVL.
TIG_MYCTU/258-418ADELQVQVGQDDLTERLVTTSR.QY-G..I.EP--------QQLFGYLQERNQLP....TMFADVRRELAIRAAV.
TIG_STAA8/264-420AEAEKIEATDEDIDKELEKMSK.QF-N..I.SV--------EDIKNTL...GNTD....IIKNDVRIQKVIDLL..
TIG_BRUA2/268-425GEKAGVEVTEEELQRAVYDQVR.RY-P..G.QE--------KEIYDFLRRTPDAV...ANLRAPIFEEKVVDHLL.
TIG_STRR6/264-421AKAEGFDASEEEIQKEVEQLAA.DY-N..M.EV--------AQVQNLL....SAD....MLKHDITIKKAVELIT.
TIG_XANCP/260-413ARRNELRLESKRVSETLRLIAS.TY-E....EP--------EQVIEMYRNDPQLM...SGLQSRVMEEQVIDWIAE
TIG_NEIMB/265-417VDENKLEPTEEQIKAVVANFAE.SY-E....DP--------QEVIDWYYADPSRL...QAPTSLAVESNVVDFVL.

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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