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122  structures 4610  species 6  interactions 21200  sequences 427  architectures

Clan: SGNH_hydrolase (CL0264)


SGNH hydrolase superfamily Add an annotation

This superfamily contains a diversity of hydrolytic enzyme activities.

This clan contains 8 families and the total number of domains in the clan is 21200. The clan was built by A Bateman.

Literature references

  1. Akoh CC, Lee GC, Liaw YC, Huang TH, Shaw JF; , Prog Lipid Res. 2004;43:534-552.: GDSL family of serine esterases/lipases. PUBMED:15522763 EPMC:15522763
  2. Lo YC, Lin SC, Shaw JF, Liaw YC; , J Mol Biol. 2003;330:539-551.: Crystal structure of Escherichia coli thioesterase I/protease I/lysophospholipase L1: consensus sequence blocks constitute the catalytic center of SGNH-hydrolases through a conserved hydrogen bond network. PUBMED:12842470 EPMC:12842470


This clan contains the following 8 member families:

DUF303 DUF459 GSCFA Hema_esterase Lipase_GDSL Lipase_GDSL_2 Lipase_GDSL_3 PC-Esterase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lipase_GDSL_2 (PF13472) 11620 (54.8%) View
Lipase_GDSL (PF00657) 4517 (21.3%) View
DUF303 (PF03629) 2378 (11.2%) View
PC-Esterase (PF13839) 1574 (7.4%) View
Hema_esterase (PF03996) 382 (1.8%) View
GSCFA (PF08885) 313 (1.5%) View
Lipase_GDSL_3 (PF14606) 244 (1.2%) View
DUF459 (PF04311) 172 (0.8%) View
Total: 8 Total: 21200 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 6 interactions for this clan. More...

Interacting families
DUF303 DUF303
Lipase_GDSL WD40
Hema_esterase Hema_HEFG


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...