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199  structures 1762  species 13  interactions 15687  sequences 409  architectures

Clan: SGNH_hydrolase (CL0264)


SGNH hydrolase superfamily Add an annotation

This superfamily contains a diversity of hydrolytic enzyme activities.

This clan contains 12 families and the total number of domains in the clan is 15687. The clan was built by A Bateman.

Literature references

  1. Akoh CC, Lee GC, Liaw YC, Huang TH, Shaw JF; , Prog Lipid Res. 2004;43:534-552.: GDSL family of serine esterases/lipases. PUBMED:15522763 EPMC:15522763
  2. Lo YC, Lin SC, Shaw JF, Liaw YC; , J Mol Biol. 2003;330:539-551.: Crystal structure of Escherichia coli thioesterase I/protease I/lysophospholipase L1: consensus sequence blocks constitute the catalytic center of SGNH-hydrolases through a conserved hydrogen bond network. PUBMED:12842470 EPMC:12842470


This clan contains the following 12 member families:

ALGX DHHW DUF459 GSCFA Hema_esterase Lipase_GDSL Lipase_GDSL_2 Lipase_GDSL_3 Lipase_GDSL_lke OSK PC-Esterase SASA

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lipase_GDSL_2 (PF13472) 6770 (43.2%) View
Lipase_GDSL (PF00657) 4857 (31.0%) View
PC-Esterase (PF13839) 2179 (13.9%) View
SASA (PF03629) 821 (5.2%) View
DHHW (PF14286) 309 (2.0%) View
ALGX (PF16822) 221 (1.4%) View
GSCFA (PF08885) 215 (1.4%) View
Lipase_GDSL_3 (PF14606) 169 (1.1%) View
DUF459 (PF04311) 99 (0.6%) View
OSK (PF17182) 23 (0.1%) View
Lipase_GDSL_lke (PF16255) 21 (0.1%) View
Hema_esterase (PF03996) 3 (0.0%) View
Total: 12 Total: 15687 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 13 interactions for this clan. More...

Interacting families
GxDLY Lipase_GDSL_3
Hema_esterase Hema_esterase
Hema_HEFG Hema_esterase
Hema_stalk Hema_esterase
Lipase_GDSL Autotransporter
Lipase_GDSL_2 Lipase_GDSL_2
Lipase_GDSL_3 Lipase_GDSL_3
WD40 Lipase_GDSL_2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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