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276  structures 9443  species 9  interactions 31640  sequences 309  architectures

Clan: HIT (CL0265)


HIT superfamily Add an annotation

The HIT superfamily are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides [1].

This clan contains 8 families and the total number of domains in the clan is 31640. The clan was built by A Bateman.

Literature references

  1. Brenner C; , Biochemistry. 2002;41:9003-9014.: Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases. PUBMED:12119013 EPMC:12119013


This clan contains the following 8 member families:

CDH CwfJ_C_1 DcpS_C DUF4921 DUF4931 GalP_UDP_tr_C GalP_UDP_transf HIT

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HIT (PF01230) 17377 (54.9%) View
GalP_UDP_transf (PF01087) 4580 (14.5%) View
GalP_UDP_tr_C (PF02744) 3813 (12.1%) View
DcpS_C (PF11969) 2928 (9.3%) View
CwfJ_C_1 (PF04677) 2091 (6.6%) View
CDH (PF02611) 314 (1.0%) View
DUF4921 (PF16268) 282 (0.9%) View
DUF4931 (PF16285) 255 (0.8%) View
Total: 8 Total: 31640 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 9 interactions for this clan. More...

Interacting families
DcpS DcpS_C
DcpS_C DcpS
GalP_UDP_tr_C GalP_UDP_tr_C
GalP_UDP_transf GalP_UDP_tr_C


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...