Summary
PH domain-like superfamily
Members of this clan share a PH-like fold. Many families in this clan bind to short peptide motifs in proteins and are involved in signalling.
This clan contains 73 families and the total number of domains in the clan is 213007. The clan was built by A Bateman.
Members
This clan contains the following 73 member families:
ASK_PH BBL5 bPH_1 bPH_2 bPH_3 bPH_4 bPH_5 bPH_6 CARM1 Carm_PH DCP1 DUF1126 DUF1681 DUF3203 EbsA FERM_C Glycoprot_B_PH1 Glycoprot_B_PH2 GRAM hSac2 ICAP-1_inte_bdg INPP5B_PH IQ_SEC7_PH IRS ISP1_C ISP3_C Jak1_Phl Mcp5_PH Myosin_TH1 OCRL_clath_bd PH PH_10 PH_11 PH_12 PH_13 PH_14 PH_15 PH_16 PH_17 PH_18 PH_19 PH_2 PH_3 PH_4 PH_5 PH_6 PH_8 PH_9 PH_BEACH PH_RBD PH_TFIIH PID PID_2 POB3_N Proteasom_Rpn13 PTB Ran_BP1 Rtt106 SCAB-PH Sec3-PIP2_bind Sharpin_PH SIN1_PH SNX17_FERM_C SPT16 SSrecog SYCP2_SLD UCH_N VID27_PH Voldacs Vps36_ESCRT-II WH1 YcxB ZFYVE21_CExternal database links
SCOP: | 50729 |
Domain organisation
Below is a listing of the unique domain organisations or architectures from this clan. More...
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Alignments
The table below shows the number of occurrences of each domain throughout the sequence database. More...
Pfam family | Num. domains | Alignment |
---|---|---|
PH (PF00169) | 77297 (36.3%) | View |
GRAM (PF02893) | 12140 (5.7%) | View |
PID (PF00640) | 11280 (5.3%) | View |
FERM_C (PF09380) | 11094 (5.2%) | View |
bPH_2 (PF03703) | 10803 (5.1%) | View |
Ran_BP1 (PF00638) | 5939 (2.8%) | View |
WH1 (PF00568) | 4667 (2.2%) | View |
PH_9 (PF15410) | 3928 (1.8%) | View |
PH_BEACH (PF14844) | 3813 (1.8%) | View |
Myosin_TH1 (PF06017) | 3494 (1.6%) | View |
Rtt106 (PF08512) | 3413 (1.6%) | View |
PH_12 (PF16457) | 3256 (1.5%) | View |
IRS (PF02174) | 3168 (1.5%) | View |
DUF1126 (PF06565) | 3094 (1.5%) | View |
PH_16 (PF17838) | 2832 (1.3%) | View |
PTB (PF08416) | 2702 (1.3%) | View |
bPH_6 (PF10756) | 2346 (1.1%) | View |
PH_RBD (PF12068) | 1895 (0.9%) | View |
PH_8 (PF15409) | 1868 (0.9%) | View |
Sec3-PIP2_bind (PF15277) | 1815 (0.9%) | View |
DCP1 (PF06058) | 1810 (0.8%) | View |
PH_19 (PF19057) | 1676 (0.8%) | View |
DUF1681 (PF07933) | 1665 (0.8%) | View |
PH_14 (PF17787) | 1561 (0.7%) | View |
PH_5 (PF15405) | 1552 (0.7%) | View |
Voldacs (PF03517) | 1478 (0.7%) | View |
Proteasom_Rpn13 (PF04683) | 1451 (0.7%) | View |
bPH_1 (PF08000) | 1451 (0.7%) | View |
IQ_SEC7_PH (PF16453) | 1437 (0.7%) | View |
SPT16 (PF08644) | 1421 (0.7%) | View |
SSrecog (PF03531) | 1412 (0.7%) | View |
POB3_N (PF17292) | 1394 (0.7%) | View |
hSac2 (PF12456) | 1388 (0.7%) | View |
YcxB (PF14317) | 1322 (0.6%) | View |
PH_10 (PF15411) | 1317 (0.6%) | View |
PH_TFIIH (PF08567) | 1161 (0.5%) | View |
Mcp5_PH (PF12814) | 1116 (0.5%) | View |
continued |
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
Family relationships
This diagram shows the relationships between members of this clan. More...
Species distribution
Tree controls
HideThis tree shows the occurrence of the domains in this clan across different species. More...
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Interactions
There are 75 interactions for this clan. More...
Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.
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