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372  structures 21921  species 6  interactions 106420  sequences 115  architectures

Clan: Iso_DH (CL0270)


Isocitrate/Isopropylmalate dehydrogenase-like superfamily Add an annotation

This superfamily of enzymes form dimers and have an active site between the two halves.

This clan contains 5 families and the total number of domains in the clan is 106420. The clan was built by A Bateman.

Literature references

  1. Sivaraman J, Li Y, Banks J, Cane DE, Matte A, Cygler M; , J Biol Chem. 2003;278:43682-43690.: Crystal structure of Escherichia coli PdxA, an enzyme involved in the pyridoxal phosphate biosynthesis pathway. PUBMED:12896974 EPMC:12896974
  2. Iyer PP, Lawrence SH, Luther KB, Rajashankar KR, Yennawar HP, Ferry JG, Schindelin H; , Structure. 2004;12:559-567.: Crystal structure of phosphotransacetylase from the methanogenic archaeon Methanosarcina thermophila. PUBMED:15062079 EPMC:15062079


This clan contains the following 5 member families:

FA_synthesis IDH Iso_dh PdxA PTA_PTB

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Iso_dh (PF00180) 44384 (41.7%) View
PTA_PTB (PF01515) 30776 (28.9%) View
FA_synthesis (PF02504) 15440 (14.5%) View
PdxA (PF04166) 10935 (10.3%) View
IDH (PF03971) 4885 (4.6%) View
Total: 5 Total: 106420 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 6 interactions for this clan. More...

Interacting families
AceK Iso_dh
FA_synthesis FA_synthesis
Iso_dh Iso_dh
PdxA PdxA


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...