Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
68  structures 1158  species 7  interactions 80242  sequences 2076  architectures

Clan: F-box (CL0271)


F-box-like domain Add an annotation

This clan includes classical F-boxes and the PRANC domain found in pox ankyrin proteins.

This clan contains 7 families and the total number of domains in the clan is 80242. The clan was built by A Bateman.

Literature references

  1. Mercer AA, Fleming SB, Ueda N; , Virus Genes. 2005;31:127-133.: F-box-like domains are present in most poxvirus ankyrin repeat proteins. PUBMED:16025237 EPMC:16025237
  2. Skowyra D, Craig KL, Tyers M, Elledge SJ, Harper JW; , Cell. 1997;91:209-219.: F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex. PUBMED:9346238 EPMC:9346238
  3. Ho MS, Tsai PI, Chien CT; , J Biomed Sci. 2006;13:181-191.: F-box proteins: the key to protein degradation. PUBMED:16463014 EPMC:16463014


This clan contains the following 7 member families:

Elongin_A F-box F-box-like F-box-like_2 F-box_4 F-box_5 PRANC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
F-box (PF00646) 38971 (48.6%) View
F-box-like (PF12937) 38562 (48.1%) View
Elongin_A (PF06881) 1044 (1.3%) View
F-box_5 (PF18511) 990 (1.2%) View
F-box_4 (PF15966) 389 (0.5%) View
PRANC (PF09372) 232 (0.3%) View
F-box-like_2 (PF13013) 54 (0.1%) View
Total: 7 Total: 80242 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 7 interactions for this clan. More...

Interacting families
Cullin F-box-like
F-box FBA
F-box-like F-box-like
Skp1 F-box


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...