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125  structures 6445  species 16  interactions 11981  sequences 130  architectures

Clan: CYTH (CL0273)


CYTH-like phosphatase superfamily Add an annotation

CyaB like adenylyl cyclase and the mammalian thiamine triphosphatases define a novel superfamily of catalytic domains called the CYTH domain that is present in all three superkingdoms of life. The catalytic core of these enzymes contain a novel alpha beta scaffold with 6 conserved acidic residues and 4 basic residues [1].

This clan contains 7 families and the total number of domains in the clan is 11981. The clan was built by A Bateman.

Literature references

  1. Iyer LM, Aravind L; , BMC Genomics 2002;3:33-33.: The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates. PUBMED:12456267 EPMC:12456267


This clan contains the following 7 member families:

CYTH Med18 Med20 mRNA_triPase Pox_ATPase-GT VTC Zwilch

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CYTH (PF01928) 6395 (53.4%) View
VTC (PF09359) 2730 (22.8%) View
Med18 (PF09637) 943 (7.9%) View
Med20 (PF08612) 807 (6.7%) View
mRNA_triPase (PF02940) 753 (6.3%) View
Zwilch (PF09817) 315 (2.6%) View
Pox_ATPase-GT (PF10640) 38 (0.3%) View
Total: 7 Total: 11981 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 16 interactions for this clan. More...

Interacting families
Med11 Med18
Med17 Med18
Med18 Med18
Med20 Med18
Med8 Med18
mRNA_triPase mRNA_cap_C
Zwilch Zwilch


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...