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169  structures 16028  species 7  interactions 192368  sequences 3388  architectures

Clan: Nucleot_cyclase (CL0276)

Summary

Nucleotide cyclase superfamily Add an annotation

This superfamily includes adenylyl cyclase and the GGDEF domain [1].

This clan contains 3 families and the total number of domains in the clan is 192368. The clan was built by A Bateman.

Literature references

  1. Pei J, Grishin NV; , Proteins 2001;42:210-216.: GGDEF domain is homologous to adenylyl cyclase. PUBMED:11119645 EPMC:11119645

Members

This clan contains the following 3 member families:

GCH_III GGDEF Guanylate_cyc

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GGDEF (PF00990) 150766 (78.4%) View
Guanylate_cyc (PF00211) 41368 (21.5%) View
GCH_III (PF05165) 234 (0.1%) View
Total: 3 Total: 192368 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 7 interactions for this clan. More...

Interacting families
A B
bZIP_1 GGDEF
GCH_III GCH_III
GGDEF EAL
GGDEF
Guanylate_cyc G-alpha
Guanylate_cyc
Response_reg GGDEF

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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