Sequence alignment for CL0276

PF00990

B2NCU3_ECOLX/273-426---------AHHDAMTGLLN-RRQFYHITEPGQMQH.LA...IAQDYSLLLIDTDRFKHINDLYG-------HSKGDEVL
Q55906_SYNY3/600-758---------SLRDPLTKLFN-RRYLEQRLSQELARA.KR...HHYSVGVLMIDVDHFKRFNDSLG-------HDAGDRIL
Y4LL_RHISN/399-555---------ARHDALTGLPN-RQFLREEFERLSDHIAP.....STRLAILCLDLDGFKAINDAYG-------RATGDLLL
YEGE_ECOLI/682-839---------ASHDALTHLAN-RASFEKQLRILLQTVNST....HQRHALVFIDLDRFKAVNDSAG-------HAAGDALL
YTRP_BACSU/423-571---------VKTDQLTELYS-RAYLDEKIQYSMKIH........QKGVFILVDIDNFKNVNDTYG-------HQTGDEIL
P74658_SYNY3/110-271---------LNLDSLTQVSN-RRHFDLHLAQQWERA.MD...SQEAIALILCDIDHFKQFNDFYG-------HLSGDDCL
P74197_SYNY3/340-500---------SHHDSLTCLPN-RRSLALFLENLHQNVHGRNNSDDQAFALLMLDLNKFKSINDRFG-------HLFGDKVL
P72790_SYNY3/288-449---------ANIDGLTHIAN-RRRFDEYLAQEWQRH.CR...EQKPLSLILVDIDYFKAYNDLYG-------HQKGDDCL
P72746_SYNY3/429-586---------ALYDPISKLPN-RVNLQKELSLAIDAAAHH....QHLMGVMFIHLEILNRINQAYG-------FGFGDEVF
YNEF_ECOLI/146-304---------ADFDFLTQVYS-RSGLYEALKSPSLKQ..T.....QHLTVMLLDIDYFKSINDNYG-------HECGDKVL
YEAP_ECOLI/174-331---------SYTDSLTGLPN-RRAIFENLTTLFSLARHL..N..HKIMIAFIDLDNFKLINDRFG-------HNSGDLFL
Q56569_VIBAN/41-198---------STHDPLTDLYN-RRYLDTWFSYQEETT..N....NKPHLLAIIDVDYFKKINDQYG-------HEAGDEVL
YEAI_ECOLI/328-485---------AVHDVLTNIYN-RRYFFNSVESLLSRP.VV...KDFCV..MLVDINQFKRINAQWG-------HRVGDKVL
PHY2_SYNY3/1100-1260---------SSLDALTQVGN-RYLFDSTLEREWQRL.QR...IREPLALLLCDVDFFKGFNDNYG-------HPAGDRCL
P73011_SYNY3/292-453---------AIYDELTQIPN-RRYFTSYLEQEWRQC.LR...QKSPISLILCDVDYFKNYNDLYG-------HQMGDKCL
P97018_AERJA/254-407---------ANRDYLTGLYN-RRYWFNEGQKWFEEQ.QR...LQSTLSLCVLDVDHFKQVNDHWG-------HAIGDQLL
P72956_SYNY3/314-475---------ANMDGLTGIAN-RRYLDHFLEQQWQKL.AK...HHQYLSLILCDIDFFKQYNDTYG-------HLEGDECL
Y1895_SYNY3/263-420---------AFYDPLTDLPN-RFLFKQELGKVLSNVQNQ....SSVLGLVLLGFRELQSLNDLLG-------HSVADEVL
YDEH_ECOLI/129-283---------SNMDVLTGLPG-RRVLDESFDHQLRNA......EPLNLYLMLLDIDRFKLVNDTYG-------HLIGDVVL
P73036_SYNY3/149-310---------AKVDQLTQLAN-RRQLELFLDTEWSEA.IR...EQYPFSILLCDIDYFKNYNDHYG-------HQGGDDCL
P74400_SYNY3/1150-1312---------AYYDPLTALPN-RRLLLDRAENALALA.QR...SKHFGAIVLIDLDGFKTLNDARG-------HDSGDRLL
YKOW_BACSU/372-530---------AHYDSLTDLPN-RRHAISHLTKVLNRE.HS...LHYNTVVFFLDLNRFKVINDALG-------HNVGDQLL
P72809_SYNY3/414-576---------AHIDGLTRIPN-RRYFEQQFAEEWQIF.LG...RGKSLTVMMVDVDHFKLYNDHYG-------HSQGDICL
Q49739_MYCLE/116-273---------ATHDCLTGLAN-RRFAEDQITKSLQHD.ER....SRLAAVLLLDLDDFKVINDSLG-------HDVGDAVL
P73272_SYNY3/180-338---------AMVDSLTRLWN-RLGIETLLKREWEYA.TR...KNSPISIVMIDFDNFKQINDQHG-------HLVGDEVL
GMR_ECOLI/237-391---------ANTDSITGLPN-RNAMQDLIDHAINHA......DNNKVGVVYLDLDNFKKVNDAYG-------HLFGDQLL
P72747_SYNY3/273-430---------TFYDPMTGLPN-HAFFEEQLAIALAKVQRD....QSRLAILFLNFYNYERMINAFG-------LGCGEILL
Q55955_SYNY3/706-867---------TQIDGLTGVYN-RRFFDQALEREWQIA.FR...ETESLTLVMLDIDYFKLYNDTLG-------HQAGDHCL
DOSC_ECOLI/295-452---------VGMDVLTKLLN-RRFLPTIFKREIAHA.NR...TGTPLSVLIIDVDKFKEINDTWG-------HNTGDEIL
O33908_9GAMM/333-502---------VFIDKLTNIPN-RRAFEQRLETYCQLL.AR...QQIGFTLIIADVDHFKEYNDTLG-------HLAGDEAL
Q55414_SYNY3/653-814---------IDIDGLTKIAN-RRCFNVRIKQEWRRL.SR...AQVPISLIMFDIDCFKNYNDRYG-------HPEGDLCL
YDAK_BACSU/132-281---------VAVDRVTGFDN-KQRMKLELSEEIKRAERY....GNSFVFLLLHMHYFKEFKSLYG-------EKETDRLF
YCDT_ECOLI/282-439---------AHRDPLTNIFN-RNYFFNELTVQSASA.QK...TPYCV..MIMDIDHFKKVNDTWG-------HPVGDQVI
YHCK_BACSU/192-351---------AHFDFLTGVYN-RRKFEETTKALYQQAADT...PHFQFALIYMDIDHFKTINDQYG-------HHEGDQVL
Q55576_SYNY3/795-953---------ANHDSLTNLPN-RSMFLDRLGHALQRNLRR...RDLRFAVLFLDLDGFKIINDSLG-------HSCGDLLL
P72748_SYNY3/162-319---------SYLDTATDLPN-QTLFLEYLNIALSNARRH....HAQVGVLLCQINNWSDLKRKRG-------DAVANAFL
CSRD_ECOLI/224-381---------AAQDVKTGLNN-RLFFDNQLATLLEDQ.EK...VGTHGIVMMIRLPDFNMLSDTWG-------HSQVEEQF
PLED_CAUCR/289-448---------AVTDQLTGLHN-RRYMTGQLDSLVKRATLG....GDPVSALLIDIDFFKKINDTFG-------HDIGDEVL
O32949_MYCLE/393-551---------AAHDTLTGLPN-RTSILARIDEQRYCG.AP...DQLLTAVLFIDLDNFKGINDSLG-------HDVGDVVL
ADRA_ECOLI/210-366---------STRDGMTGVYN-RRHWETMLRNEFDNC.RR...HNRDATLLIIDIDHFKSINDTWG-------HDVGDEAI
PHY2_SYNY3/431-592---------TAYDPLTQLPN-WIIFNRQLTLALLDALYE..G..KMVGVLVIAMDRFKRINESFG-------HKTGDGLL
YEDQ_ECOLI/398-557---------AWHDTLTRLYN-RGALFEKARPLAKLCQT....HQHPFSVIQVDLDHFKAINDRFG-------HQAGDRVL
P72843_SYNY3/410-567---------AHYDHLTGLPN-RILAKDRLQQAIESA.LR...QKHIFGLMFLDLDNFKKVNDTLG-------HDAGDQLL
YEAJ_ECOLI/344-495---------NISDAMTGLYN-RKILTPELEQRLQKLVQS....GSSVMFIAIDMDKLKQINDTLG-------HQEGDLAI
P73380_SYNY3/304-462---------ALHDTLTGLAN-RALLLQRLEFAGHQIKNN...PKSRFALLFIDLDHFKLINDSWG-------HSVGDALL
Y1389_MYCBO/184-339---------ADHDDLTGLHN-RRALLQHLDQRLAPG......QPGPVAALFLDLDRLKAINDYLG-------HAAGDQFI
YREP_STRAM/29-178---------ARRDPLTGLHT-RAGWTARAEHCIHRH........PRAAVLLVDLDHFKTLNDTHG-------HAAGDAAL
YFIN_ECOLI/249-405---------ALHDPLTGLAN-RAAFRSGINTLMNNSDAR.....KTSALLFLDGDNFKYINDTWG-------HATGDRVL
P73713_SYNY3/801-959---------SIRDPLTGLFN-RRYLEQFFLQEIGRA.KR...YNHSIGVIMGDIDHFKQFNDQLG-------HDAGDHVL

PF00211

ADCY1_BOVIN/296-480------IYIQRHDNVSILFA-DIVGFTGLASQCT....A----QELVKLLNELFGKFDELATENH...CRRIKILGDCYY
CYAA_STRCO/182-373------DEEMVDRRLAVGFA-DLVGFTRLTRRME....E----EELGELVEAFETTSADLVAARG...GRLVKTLGDEVL
CYAG_DICDI/387-572------VVAERSNNACVFFL-DIAGFTRFSSIHS....P----EQVIQVLIKIFNSMDLLCAKHG...IEKIKTIGDAYM
GCYB2_RAT/399-582------VAAGEFETCTILFS-DVVTFTNICAACE....P----IQIVNMLNSMYSKFDRLTSVHD...VYKVETIGDAYM
CYAA_DICDI/1180-1356------VYVQPHQDVSIMFI-QIAGFQEYDE.......P----KDLIKKLNDIFSFFDGLLNQKYGGTVEKIKTIGNTYM
GUC2C_HUMAN/815-1002------VEPELYEEVTIYFS-DIVGFTTICKYST....P----MEVVDMLNDIYKSFDHIVDHHD...VYKVETIGDAYM
CYAA_ANACY/311-501------VGAASTRRMTILFC-DIRGYTSMSEAME....P----IEIFRFLNDYLACMGKAIDEAG...GFIDKYIGDAIM
ADCY9_MOUSE/385-573------FKMQQIEEVSILFA-DIVGFTKMSANKS....A----HALVGLLNDLFGRFDRLCEQTK...CEKISTLGDCYY
ADCY3_RAT/310-494------MYMYRHENVSILFA-DIVGFTQLSSACS....A----QELVKLLNELFARFDKLAAKYH...QLRIKILGDCYY
ADCY3_RAT/914-1121------LYSQSYDEIGVMFA-SLPNFADFYTEESINNGG----IECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYM
GCYH_DROME/457-647------IDAKTYPDVTILFS-DIVGFTSICSRAT....P----FMVISMLEGLYKDFDEFCDFFD...VYKVETIGDAYC
ADCY1_BOVIN/862-1059------LYYQSYSQVGVMFA-SIPNFNDFYIELDGNNMG----VECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYM
CYAA_STIAU/221-410------ETSPELREVTLLFA-DIRDFTSLSERLR....P----EQVVTLLNEYYGRMVEVVFRHG...GTLDKFIGDALM
CYAA_TRYEQ/94-307------APKELTDPVTLIFT-DIESSTALWAAH.....P----ELMPDAVATHHRLIRSLIGRYG...CYEVKTVGDSFM
ANPRA_HUMAN/867-1053------VQAEAFDSVTIYFS-DIVGFTALSAEST....P----MQVVTLLNDLYTCFDAVIDNFD...VYKVETIGDAYM
ADCY2_HUMAN/878-1078------LYHQSYDCVCVMFA-SIPDFKEFYTESDVNKEG----LECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYM
GCY1_CAEEL/889-1077------VEPEGFDSVTVFFS-DVVKFTILASKCS....P----FQTVNLLNDLYSNFDTIIEQHG...VYKVESIGDGYL
CYAA_SCHPO/1323-1519------EVSPPKGCIAMVFT-DIKNSTLLWERH.....P----IAMRSAIKTHNTIMRRQLRATG...GYEVKTEGDAFM
GCYA1_BOVIN/473-660------VQAKRFGNVTMLFS-DIVGFTAICSQCS....P----LQVITMLNALYTRFDRQCGELD...VYKVETIGDAYC
ADCY8_HUMAN/973-1172------LYSQSYDAVGVMFA-SIPGFADFYSQTEMNNQG----VECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYM
GCYB1_BOVIN/412-605------VPAKRYDNVTILFS-GIVGFNAFCSKHASGEGA----MKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM

PF05165

GCH3_AERPE/15-241V.........GYREWTEELGSDREWIIQTLQSDIYAAAQKEAAGYGGFVLPIRYDIMLLISSNMG-------VQEHARVL
GCH3_METJA/1-250MIQITVIQIDNYGPWTVTPNPRRESDLQALQSRLYADLNLMFGAHKGLVFYTRFDNLIAITNGID-------LITHKRIQ
GCH3_METTH/1-249MIQMTLIQIDNYGPWTVTPTPRNEADLQIMQAELYADLQRQFAARQGLVFFTRFDNMLAVTNGMD-------LEDHRRIQ
GCH32_HALSA/1-253M...AAVQIDDYGPWTTEPAPRRETDLQALQARLFADVADFLGGRDGYAFAGRFDNMVGAATGIA-------PAAFERLQ

PF00990

B2NCU3_ECOLX/273-426CALART-------------------LESCARK....GDLVFRWGGEEFVLLLPRTPLD.---------------------
Q55906_SYNY3/600-758ASIGTL-------------------LKNNIRT....SDVACRYGGEEITIILPDATLE.---------------------
Y4LL_RHISN/399-555RHVTER-------------------LRNFLKQ....SDILCRLSGDEFVVLRVGINSN.---------------------
YEGE_ECOLI/682-839RELASL-------------------MLSMLRS....SDVLARLGGDEFGLLLPDCNVE.---------------------
YTRP_BACSU/423-571IQVASV-------------------IKSNIRK....HDVGARWGGEELAIYLPNVPVA.---------------------
P74658_SYNY3/110-271RRIAKT-------------------LSATLRN...PFDLFARYGGEEFGVILPQVTSE.---------------------
P74197_SYNY3/340-500QRVAEI-------------------LLECVRD....GDQVARLSGDEFIIVLKSTK...---------------------
P72790_SYNY3/288-449QKVANT-------------------LVDIAKR...ITDLVARYGGEEFVIVLPNTNRQ.---------------------
P72746_SYNY3/429-586MAFHGA-------------------ISDCMRS....GDTVGQWDSNTLVIILAKIKSP.---------------------
YNEF_ECOLI/146-304SVFARH-------------------IQKIVGD....KGLVARMGGEEFAVAVPSVN.P.---------------------
YEAP_ECOLI/174-331IQVGER-------------------LNTLQQN....GEVIGRLGGDEFLVVSLNNEN..---------------------
Q56569_VIBAN/41-198RALSTI-------------------LKQQLRP....EDLLMRWGGEEFVMIISTPEAH.---------------------
YEAI_ECOLI/328-485VSIVDI-------------------IQQSIRP....DDILARLEGEVFGLLFTELNSA.---------------------
PHY2_SYNY3/1100-1260KKIADA-------------------MAKVAKR...PTDLVARYGGEEFAIILSETSLE.---------------------
P73011_SYNY3/292-453QSVAKV-------------------IQNALKR...PSDVLARYGGEEFIVILPYTDQS.---------------------
P97018_AERJA/254-407CHLTRQ-------------------LTQFFPD.....AMIARFGGEEFALMVPHCSVP.---------------------
P72956_SYNY3/314-475KKVANL-------------------LKKVMRR...GTDLTARYGGEEFALVLPQTNKQ.---------------------
Y1895_SYNY3/263-420KIITER-------------------LSAHVRL....EDLLCRWRGDTFILLIQSCRN..---------------------
YDEH_ECOLI/129-283RTLATY-------------------LASWTRD....YETVYRYGGEEFIIIVKAANDE.---------------------
P73036_SYNY3/149-310QQVAKA-------------------LTRVVHR...PKDLAARYGGEEFLIVLPNTDLQ.---------------------
P74400_SYNY3/1150-1312QMVAKR-------------------LADSLRD....SDTVARLGGDEFIVLLPELAHDR---------------------
YKOW_BACSU/372-530QFAAKR-------------------LSSVVPD....NGFIARLGGDEFIIILTDANT..---------------------
P72809_SYNY3/414-576AEIAQI-------------------LQCCIRQP..GSDFVARYGGEEFVLVLPEVDQF.---------------------
Q49739_MYCLE/116-273QTVAQR-------------------LRSAVRP....DDVVARLGGDEFIVLLRGPLSD.---------------------
P73272_SYNY3/180-338QGSARL-------------------IISVLRS....YDILGRWGGDEFMLILPGSGRE.---------------------
GMR_ECOLI/237-391RDVSLA-------------------ILSCLEH....DQVLARPGGDEFLVLASNTS...---------------------
P72747_SYNY3/273-430KTVAKR-------------------LSQWTEK....RGLACRWQGKQFAILLKEPGDN.---------------------
Q55955_SYNY3/706-867RIVAAI-------------------LQESVHR...TSDLVARYGGEEFALILPRTDLS.---------------------
DOSC_ECOLI/295-452RKVSQA-------------------FYDNVRS....SDYVFRYGGDEFIIVLTEASEN.---------------------
O33908_9GAMM/333-502IKVAQT-------------------LSQQFYR...AEDICARFGGEEFIMLFRDIPDE.---------------------
Q55414_SYNY3/653-814IRVAQA-------------------ARKAASR...PADLVARFGGEEFAVLLPETDTK.---------------------
YDAK_BACSU/132-281QYVGQQ-------------------IRTSVRE....TDKKFRPSDERIGIVLTHTP...---------------------
YCDT_ECOLI/282-439KTVVNI-------------------IGKSIRP....DDLLARVGGEEFGVLLTDIDTE.---------------------
YHCK_BACSU/192-351KELGLR-------------------LKQTIRN....TDPAARIGGEEFAVLLPNCSLD.---------------------
Q55576_SYNY3/795-953QGIAHR-------------------LRQCLRP....EDTLARLGGDEFTMLIENIT...---------------------
P72748_SYNY3/162-319QEAGQK-------------------LKSNLRN....GDIVSRWDKDEFIFLVSKVQDT.---------------------
CSRD_ECOLI/224-381FTLTNL-------------------LSTFMMRY..PGALLARYHRSDFAALLPHRTLK.---------------------
PLED_CAUCR/289-448REFALR-------------------LASNVRA....IDLPCRYGGEEFVVIMPDTALA.---------------------
O32949_MYCLE/393-551QTAAQR-------------------LRAGLRS....RDVVGRFGGDEFVALILGKITH.---------------------
ADRA_ECOLI/210-366VALTRQ-------------------LQITLRG....SDVIGRFGGDEFAVIMSGTPAE.---------------------
PHY2_SYNY3/431-592QEVADR-------------------LNQKLSPLAAYSPLLSRWHGDGFTILLTQISDN.---------------------
YEDQ_ECOLI/398-557SHAAGL-------------------ISSSLRA....QDVAGRVGGEEFCVILPGASLT.---------------------
P72843_SYNY3/410-567VEVSER-------------------LQRALRQ....TDTVARLGGDEFLIILDQVS...---------------------
YEAJ_ECOLI/344-495TLLAQA-------------------IKQSIRK....SDYAIRLGGDEFCIILVDSTPQ.---------------------
P73380_SYNY3/304-462IKIAEK-------------------LQINLRE....TDLAVRLGGDEFVIFLESIT...---------------------
Y1389_MYCBO/184-339HVFAQR-------------------IGDALVG....ESLIARLGGDEF.VLIPASPMS.---------------------
YREP_STRAM/29-178IATAHR-------------------LSSWCGR....HGTAGRLGGDEFVTAIRDLD...---------------------
YFIN_ECOLI/249-405IEIAKR-------------------LAEFGGL....RHKAYRLGGDEFAMVLYDVQSE.---------------------
P73713_SYNY3/801-959KTIGRI-------------------LQSNIRG....SDIACRYGGEEMTIVLPQTSLE.---------------------

PF00211

ADCY1_BOVIN/296-480CVSGLT....................QPKTDH----AHCCVEMGLDMIDTI.TSVAEAT..E..................
CYAA_STRCO/182-373YAADDA..........................----.GTAAEIALLLVETMAHDETMPE.....................
CYAG_DICDI/387-572ATCGIF.................PKCDDIRHN----TYKMLGFAMDVLEFIPKEMSFH......................
GCYB2_RAT/399-582VVGGVP....................VPVESH----AQRVANFALGMRISA.KEVMNPVTG...................
CYAA_DICDI/1180-1356AVSGLD.....................GSPSF----LEKMSDFALDVKAYT.NSVAISR.....................
GUC2C_HUMAN/815-1002VASGLP...................KRNGNRH----AIDIAKMALEILSFM.GTFELEHLPG..................
CYAA_ANACY/311-501ALFDDG...................NTDCALH----AAILMQQALDKFNDE.RSMQTGKTGL..................
ADCY9_MOUSE/385-573CVAGCP....................EPRADH----AYCCIEMGLGMIKAI.EQFCQEK..K..................
ADCY3_RAT/310-494CICGLP....................DYREDH----AVCSILMGLAMVEAI.SYVREKT..K..................
ADCY3_RAT/914-1121AASGVT..PDVNTNGFTSSSKEEKSDKERWQH----LADLADFALAMKDTL.TNINNQS..F..................
GCYH_DROME/457-647VASGLH....................RASIYD----AHKVAWMALKMIDACSKHITHDG.....................
ADCY1_BOVIN/862-1059AAVGLA..PTAGT..........KAKKCISSH----LSTLADFAIEMFDVL.DEINYQS..Y..................
CYAA_STIAU/221-410VYFGAP....................IADPAH----ARRGVQCALDMVQEL.ETVNALRSAR............GE....
CYAA_TRYEQ/94-307IASKSP.......................FAA----VQLAQELQLCFLHHDWGTNAIDESYQQLEQQRAEEDAKYTPPTA
ANPRA_HUMAN/867-1053VVSGLP...................VRNGRLH----ACEVARMALALLDAV.RSFRIRHRPQ..................
ADCY2_HUMAN/878-1078AATGLSAVPSQEHS.........QEPERQYMH----IGTMVEFAFALVGKL.DAINKHS..F..................
GCY1_CAEEL/889-1077CVSGLP...................TRNGYAH----IKQIVDMSLKFMEYC.KSFNIPHLPR..................
CYAA_SCHPO/1323-1519VCFQTV.......................PAA----LLWCFSVQLQLLSADWPNEIVESVQGRLVLGSKNEVLY......
GCYA1_BOVIN/473-660VAGGLH....................KESDTH----AVQIALMALKMMELSHEVVSPHG.....................
ADCY8_HUMAN/973-1172AVSGLS..PEK............QQCEDKWGH----LCALADFSLALTESI.QEINKHS..F..................
GCYB1_BOVIN/412-605TVSGLP....................EPCIHH----ARSICHLALDMMEIA.GQVQVDG.....................

PF05165

GCH3_AERPE/15-241DAIAGL-------------SKVKVRMASYCGVKPLDAVERAWNALRRREERLIYERCE............GEEYTAIAHI
GCH3_METJA/1-250ESIRNR-------------YPFTVSMVIASAETPYEAQKLATETLQEYGSAQDENRKEVLDVANEL...VVDGYVQIAHI
GCH3_METTH/1-249KSIGNR-------------YPITVSMGVGAAETPYDAQRNASRALQSHGGAQSEERKEVLAI.DGL...VDEGYVQIAHI
GCH32_HALSA/1-253ERIRNR-------------YPVTVSVGIGTARTPADALDAAGTALRDAGSAQDENRQEALSHRSPPGFAGTPGAVTIAHF

PF00990

B2NCU3_ECOLX/273-426-----------..TALSLAETIRVSVAKVSI..-...SGLPR.FTVSIGVAHH....----------------------.
Q55906_SYNY3/600-758-----------..EASQKAEFLRQAIAEMKIEY-.SGKIVNS.VTASFGVACY....----------------------.
Y4LL_RHISN/399-555-----------....AEARLLAQQLIDVIEAPY-.ELAGTHVDLQVVVGLAAA....----------------------.
YEGE_ECOLI/682-839-----------..SARFIATRIISAVNDYHFIW-.EGRVHR..VGASAGITLID...----------------------.
YTRP_BACSU/423-571-----------..VGKRITERLVYAVRKNTKP.-......E..VTISCGISCWT...----------------------.
P74658_SYNY3/110-271-----------..AAQQIAKRMQASLTMLEIPH-.HHSPTSEFVTMSFGIGRLY...----------------------.
P74197_SYNY3/340-500-----------..SGDDAKKCADRIHRLFSRPL-.TMEGIQLLISTSIGIVIS....----------------------.
P72790_SYNY3/288-449-----------..DALAMAENMLQAIAALAIPH-.EGSSVSKYVTISIGVSSII...----------------------.
P72746_SYNY3/429-586-----------....QDSIRLAERILDRLKNPI-.TVREREFIFNINIGISAYP...----------------------.
YNEF_ECOLI/146-304-----------.VDGLLMAEKIRKGVELQPFTW-.QQKTLYLTVSIGVGSGRAS...----------------------.
YEAP_ECOLI/174-331-----------...ADISSLRERIQQQIRGEYH-.LGDVDLYYPGASLGIVEVD...----------------------.
Q56569_VIBAN/41-198-----------...IKEVLERIRAQVEQTSFYW-.AGQRVP..VTVSIGAIAEKS..----------------------.
YEAI_ECOLI/328-485-----------..QAKIIAERMRKNVELLTGFS-.NRYDVPEQMTISIGTVFS....----------------------.
PHY2_SYNY3/1100-1260-----------..GAINVTEALQVEVANLAIPH-.TVSGTG.HVTLSIGIAVYT...----------------------.
P73011_SYNY3/292-453-----------..GAYTVGQRIHHCLAEAQISH-.ADSPTSRYLTISLGIGTTV...----------------------.
P97018_AERJA/254-407-----------.....VLLKRLEGLRQQLRQHP-.LSPDVPLFVRASYGVVSVG...----------------------.
P72956_SYNY3/314-475-----------..GCQNVVIHLQSVFKQAQIPH-.RSSIIQPYLTLSIGSATMV...----------------------.
Y1895_SYNY3/263-420-----------...LDEIEVFVRRLLAVLKRPF-.FIANNPLYLQGYAGIACYP...----------------------.
YDEH_ECOLI/129-283-----------..EACRAGVRICQLVDNHAITH-.SEGHIN..ITVTAGVSRA....----------------------.
P73036_SYNY3/149-310-----------..GAIHIGEDIQAEITRLAIPH-.VQSAIADHVTLSIGCASTI...----------------------.
P74400_SYNY3/1150-1312-----------ELAARLGLGVGEKIRQALATPF-.TLEAEQVQISGSIGITLF....----------------------.
YKOW_BACSU/372-530-----------..GTGEADVLARKIIQKFKKPF-.KIQDHTLVTSVSIGIAIS....----------------------.
P72809_SYNY3/414-576-----------..GAIAIAQRIKTALQTRNISH-.HAVDLAGNVTCSIGIAVAH...----------------------.
Q49739_MYCLE/116-273-----------....MNANDVAKRLHTTLSESL-.VVDQLTVPIGASVGILEVR...----------------------.
P73272_SYNY3/180-338-----------..QTAVLLERIQATIAQNPVPT-.SAGPMA..ISLSMGGVSVF...----------------------.
GMR_ECOLI/237-391-----------...QSALEAMASRILTRLRLPF-.RIGLIEVYTSCSVGIALS....----------------------.
P72747_SYNY3/273-430-----------....QALTEMVKEMLAMLEESI-.DVAKQKIHLKGKVGIAVYP...----------------------.
Q55955_SYNY3/706-867-----------..GAVIVAQRIKTLMDAKAISH-.PTSEIANYVTVSIGIHCAV...----------------------.
DOSC_ECOLI/295-452-----------..ETLRTAERIRSRVEKTKL.K-.AANGEDIALSLSIGAAMF....----------------------.
O33908_9GAMM/333-502-----------..PLQRKLDAMLHSFAELNLPH-.PNSSTANYVTVSLGVCTVVAVD----------------------D
Q55414_SYNY3/653-814-----------..GAIMVAEKIIQAISQLAIAH-.EASPISGQITISLGIGTQF...----------------------.
YDAK_BACSU/132-281-----------....AEHMPAVLTKLKKQLDTY-.QLE.NGKYVSLTFHVCYLP...----------------------.
YCDT_ECOLI/282-439-----------..RAKALAERIRENVERLTGDN-.PEYAIPQKVTISIGAVVT....----------------------.
YHCK_BACSU/192-351-----------..KAARIAERIRSTVSDAPIVL-.T.NGDELSVTISLGAAHY....----------------------.
Q55576_SYNY3/795-953-----------..CPEDVIAVAQRIHQELQKPF-.NLNGQEIFTNTSIGIALN....----------------------.
P72748_SYNY3/162-319-----------....SSLLGIAQRLMKPVLAPV-.TAGGRPFQPEITYGVALYP...----------------------.
CSRD_ECOLI/224-381-----------.....EAESIAGQLIKAVDTLP-.NNKMLDRDDMIHIGICAWR...----------------------.
PLED_CAUCR/289-448-----------..DALRIAERIRMHVSGSPFTV-.AHGREMLNVTISIGVSAT....----------------------.
O32949_MYCLE/393-551-----------....TELSKVVDRMHAALSEPT-.YVADAVLHLRASIGVVAIK...----------------------.
ADRA_ECOLI/210-366-----------..SAITAMLRVHEGLNTLRLP.-...NTPQVTLRISVGVAPLN...----------------------.
PHY2_SYNY3/431-592-----------....QEMIPLCERLLSTFQEPF-.FLQGQPIYLTASMGISTAP...----------------------.
YEDQ_ECOLI/398-557-----------..EAAEVAERIRLKLNEKEMLI-.AKSTTIR.ISASLGVSSSE...----------------------.
P72843_SYNY3/410-567-----------..HSRKLMAIAQRLLRVMRQPV-.NLQGLEFFVHGSIGITVF....----------------------.
YEAJ_ECOLI/344-495-----------..IAAQLPERIEKRLQHIAPQK-.E....IG...FSSGIYAMK...----------------------.
P73380_SYNY3/304-462-----------..EIKQAIDVAERILIHLRLPV-.QIQAKELFVKASIGIVIG....----------------------.
Y1389_MYCBO/184-339-----------...ADAAQPLAERLRDQLKDHV-.AIGGEVLTRTVSIGVASG....----------------------.
YREP_STRAM/29-178-----------.......AVDLDALTTALHQPT-.NYDGTALPLAASVGVCRVA...----------------------.
YFIN_ECOLI/249-405-----------....SEVQQICSALTQIFNLPF-DLHNGHQTTMTLSIGYAMTI...----------------------.
P73713_SYNY3/801-959-----------..DTLVKAESLRQAIASMEVEY-.KGKELGT.LTVSLGVACY....----------------------.

PF00211

ADCY1_BOVIN/296-480...........VDLNMRVGLHTGRVLCGVLG..--LRKWQYDVWSNDVTLANVM--------------------------
CYAA_STRCO/182-373...............LRVGIAFGTVTTRMG...--......DVFGTTVNLASRL--------------------------
CYAG_DICDI/387-572...........LGLQVRVGIHCGPVISGVISG.--YAKPHFDVWGDTVNVASRM--------------------------
GCYB2_RAT/399-582...........EPIQIRVGIHTGPVLAGVVG..--DKMPRYCLFGDTVNTASRM--------------------------
CYAA_DICDI/1180-1356..............VVRIGISHGPLVAGCIG..--ISRAKFDVWGDTANTASRM--------------------------
GUC2C_HUMAN/815-1002...........LPIWIRIGVHSGPCAAGVVG..--IKMPRYCLFGDTVNTASRM--------------------------
CYAA_ANACY/311-501...........PRISVGIGIHRGTVVMGTVGF.--TSRIDSTVIGDAVNVASRI--------------------------
ADCY9_MOUSE/385-573...........EMVNMRVGVHTGTVLCGILG..--MRRFKFDVWSNDVNLANLM--------------------------
ADCY3_RAT/310-494...........TGVDMRVGVHTGTVLGGVLG..--QKRWQYDVWSTDVTVANKM--------------------------
ADCY3_RAT/914-1121...........NNFMLRIGMNKGGVLAGVIG..--ARKPHYDIWGNTVNVASRM--------------------------
GCYH_DROME/457-647...........EQIKMRIGLHTGTVLAGVVG..--RKMPRYCLFGHSVTIANKF--------------------------
ADCY1_BOVIN/862-1059...........NDFVLRVGINVGPVVAGVIG..--ARRPQYDIWGNTVNVASRM--------------------------
CYAA_STIAU/221-410...........PCLRIGVGVHTGPAVLGNIGSA--TRRLEYTAIGDTVNLASRI--------------------------
CYAA_TRYEQ/94-307RLDLKVYSRLWNGLRVRVGIHTGLCDIRRD...--EVTKGYDYYGRTSNMAART--------------------------
ANPRA_HUMAN/867-1053...........EQLRLRIGIHTGPVCAGVVG..--LKMPRYCLFGDTVNTASRM--------------------------
ADCY2_HUMAN/878-1078...........NDFKLRVGINHGPVIAGVIG..--AQKPQYDIWGNTVNVASRM--------------------------
GCY1_CAEEL/889-1077...........ENVELRIGVNSGPCVAGVVG..--LSMPRYCLFGDTVNTASRM--------------------------
CYAA_SCHPO/1323-1519...........RGLSVRIGVNYGVTVSELD...--PITRRMDYYGPVVNRTSRV--------------------------
GCYA1_BOVIN/473-660...........EPIKMRIGLHSGSVFAGVVG..--VKMPRYCLFGNNVTLANKF--------------------------
ADCY8_HUMAN/973-1172...........NNFELRIGISHGSVVAGVIG..--AKKPQYDIWGKTVNLASRM--------------------------
GCYB1_BOVIN/412-605...........ESVQITIGIHTGEVVTGVIG..--QRMPRYCLFGNTVNLTSRT--------------------------

PF05165

GCH3_AERPE/15-241DLNNVT.AITRAEGPVRTYYEVMDLMAKISKVA.EKIGAITQYLGGDNILA.........VLPLNGSVKETVDMLLVRSD
GCH3_METJA/1-250DINNITGTLTDIVSAYDTYLNVNKVKLALMEEL.LKYNALLFFIGGDNFMAPSNGMSEEDFLDIFNRINKKYKI.....E
GCH3_METTH/1-249DINGITETMTDIVPAYDTSFIVNRVQHFLMKKL.IKEGALLFFIGGDNFMSPCNGLEPQGLLRIINEIDDEINV.....A
GCH32_HALSA/1-253DVVDATGTYTDTVSPVRAGTEIQGAVTTLAEYLYDTHDAVTQFVGGDNAIAVCPEIDAGIVDDATAHVREAAGV.....D

PF00990

B2NCU3_ECOLX/273-426.....EGNESIDELFKRVDDALYRAK---------------NDGRNR---------------------------------
Q55906_SYNY3/600-758....PDHGETGQEIIQIADKALYDAK---------------QAGRNR---------------------------------
Y4LL_RHISN/399-555....SKSDQSLDELIKTADIALERAK---------------TGGGGT---------------------------------
YEGE_ECOLI/682-839.....DNNHQAAEVMSQADIACYASK---------------NGGRGR---------------------------------
YTRP_BACSU/423-571....TETKKSLKELVHEADEALYSAK---------------RSGKNR---------------------------------
P74658_SYNY3/110-271....PQPGQLPLDLIAQADENLYKAK---------------RQGRNC---------------------------------
P74197_SYNY3/340-500....NYEQFDYDRLIDYADTAMYEAK---------------RNG.EL---------------------------------
P72790_SYNY3/288-449....PMPEDTIERIISEADQALYSAK---------------SQGRNR---------------------------------
P72746_SYNY3/429-586.....NDGNRAEDLLSRANAALQKLR---------------QTGFNH---------------------------------
YNEF_ECOLI/146-304...YLTLTDDFNKLMVEADTCLYRSK---------------KDGRNR---------------------------------
YEAP_ECOLI/174-331.....PETTDADSALHAADIAMYQEK---------------KHKQKT---------------------------------
Q56569_VIBAN/41-198...VSKLALSWQSAMESADQALYQAK---------------SEGRNR---------------------------------
YEAI_ECOLI/328-485....TGDTRNISLVMTEADKALREAK---------------SEGGNK---------------------------------
PHY2_SYNY3/1100-1260....PERHINPNALVKAADLALYEAK---------------AKGRNQ---------------------------------
P73011_SYNY3/292-453....PLLHYHPSDLIKIADQALYAAK---------------AAGRNQ---------------------------------
P97018_AERJA/254-407.......RVSMDEALSEADRLLYQAK---------------NTGRDK---------------------------------
P72956_SYNY3/314-475....PLPNVPPKQLIDWADQALFKAK---------------KAGRNC---------------------------------
Y1895_SYNY3/263-420.....NHGDNVEILLNRVGIALNEVK---------------DIGSRQ---------------------------------
YDEH_ECOLI/129-283.....FPEEPLDVVIGRADRAMYEGK---------------QTGRNR---------------------------------
P73036_SYNY3/149-310....PRLGSDWGKLVGAADQYLYEAK---------------AQGRNR---------------------------------
P74400_SYNY3/1150-1312....PKLNEKVSDLFKEADTAMYQAK---------------KAGRDK---------------------------------
YKOW_BACSU/372-530....PKDGTDGLELMKKADMAMYAAK---------------ERNKSK---------------------------------
P72809_SYNY3/414-576....SRFASSKETLLKQADQALYCAK---------------QAGRNQ---------------------------------
Q49739_MYCLE/116-273....PDDRRRAADILRDADSAMYAAK---------------NKKQCA---------------------------------
P73272_SYNY3/180-338....TNQGEALQYWVEQADNQLMKVK---------------RLGKGN---------------------------------
GMR_ECOLI/237-391....PEHGSDSTAIIRHADTAMYTAK---------------EGGRGQ---------------------------------
P72747_SYNY3/273-430.....DGGTDGATLLKNSHTALEQIK---------------EKHFDS---------------------------------
Q55955_SYNY3/706-867....PRPGLSLASWVKCADDALYQAK---------------KRGRNG---------------------------------
DOSC_ECOLI/295-452.....NGHPDYERLIQIADEALYIAK---------------RRGRNR---------------------------------
O33908_9GAMM/333-502FEFKSESHIIGSQAALIADKALYHAK---------------ACGRNQ---------------------------------
Q55414_SYNY3/653-814....PSKELISRTLIKQADMALYEAK---------------RRGRNQ---------------------------------
YDAK_BACSU/132-281.......YRN...DIQTADQFLEELE---------------NEMMMN---------------------------------
YCDT_ECOLI/282-439....QENALNPNEIYRLADNALYEAK---------------ETGRNK---------------------------------
YHCK_BACSU/192-351....PNNTEQPGSLPILADQMLYKAK---------------ETGRNR---------------------------------
Q55576_SYNY3/795-953....HPHYGHPQDVLRDADTAMYRAK---------------AAGKGR---------------------------------
P72748_SYNY3/162-319.....VDGEQVNDLIGHIRENLQQLL---------------PQPTNP---------------------------------
CSRD_ECOLI/224-381......SGQDTEQVMEHAESATRNAG---------------LQGGNS---------------------------------
PLED_CAUCR/289-448....AGEGDTPEALLKRADEGVYQAK---------------ASGRNA---------------------------------
O32949_MYCLE/393-551....GDDPRNIGQILRDADTAMYRAK---------------LSGEGT---------------------------------
ADRA_ECOLI/210-366.....PQMSHYREWLKSADLALYKAK---------------KAGRNR---------------------------------
PHY2_SYNY3/431-592.....YDGETAESLLKFAEIALTRAK---------------CQGKNT---------------------------------
YEDQ_ECOLI/398-557....ETGDYDFEQLQSLADRRLYLAK---------------QAGRNR---------------------------------
P72843_SYNY3/410-567....PDDGFHADVLLRNADTAMYAAK---------------LAGRNM---------------------------------
YEAJ_ECOLI/344-495......ENDTLHDAYKASDERLYVNK---------------QNKNSR---------------------------------
P73380_SYNY3/304-462....SIHYYEPERLIRDADIAMYQAK---------------NNGRNQ---------------------------------
Y1389_MYCBO/184-339....TPGQHTPSDLLRRADQAALAAK---------------HAGGDS---------------------------------
YREP_STRAM/29-178....ELPVPALTDALAAADAAMYAAK---------------GRSRRG---------------------------------
YFIN_ECOLI/249-405......EHASAEKLQELADHNMYQAK---------------HQRAEK---------------------------------
P73713_SYNY3/801-959....PNHGETMVNIIQAADRALYQAK---------------AAGRNR---------------------------------

PF00211

ADCY1_BOVIN/296-480----EAAGLPGKVHI..TKTTLACLN...............GDYEVEP.......GHGHER......NSFLKTHNIETFF
CYAA_STRCO/182-373----TSIAPKDAVLV.DTAFAEELIRTRDAPASEAAAAEEAAAAEKEGEEPPVYRF....ALQPMWQRPVRGLGVVEPWL
CYAG_DICDI/387-572----ESTGIAGQIHV..SDRVYQLGK......EDFNFSERCDIIHVK........G....K............GRMKTWY
GCYB2_RAT/399-582----ESHGLPSKVHL..SPTAHRALK.....NKGFEIVRR.GEIEVK........G....K............GKMTTYF
CYAA_DICDI/1180-1356----QSNAQDNEIMV..THSVYERLN......KLFYFDDE.KEILVK........G....K............GKMVTHV
GUC2C_HUMAN/815-1002----ESTGLPLRIHV..SGSTIAILK...RTECQFLYEVR.GETYLK........G....R............GNETTYW
CYAA_ANACY/311-501----EGLTKQYGCNILITESVVRNLS....CPESFSLRLIDKSVKVK........G....K............DEAISIY
ADCY9_MOUSE/385-573----EQLGVAGKVHI..SEATAKYLD...............DRYEMED.......GRVIERLGQSVVADQL..KGLKTYL
ADCY3_RAT/310-494----EAGGIPGRVHI..SQSTMDCLK...............GEFDVEP.......GDGGSR......CDYLDEKGIETYL
ADCY3_RAT/914-1121----ESTGVMGNIQV..VEETQVILR.....EYGFRFVRR.GPIFVK........G....K............GELLTFF
GCYH_DROME/457-647----ESGSEALKINV..SPTTKDWLT..KHEGFEFELQPR.DPSFLPKEFPN..PG.................GTETCYF
ADCY1_BOVIN/862-1059----DSTGVQGRIQV..TEEVHRLLR.....RGSYRFVCR.GKVSVK........G....K............GEMLTYF
CYAA_STIAU/221-410----ESLTKTRDVPILASRATREQAG......DTFLWNEM.APASVP........G....K............SQPVAIF
CYAA_TRYEQ/94-307----ESVGNGGQVLM..TTAAYMSLS..AEEREQIDVTAL.GDVPLR........GVA...............KPVEMYQ
ANPRA_HUMAN/867-1053----ESNGEALKIHL..SSETKAVLE....EFGGFELELR.GDVEMK........G....K............GKVRTYW
ADCY2_HUMAN/878-1078----DSTGVLDKIQV..TEETSLVLQ.....TLGYTCTCR.GIINVK........G....K............GDLKTYF
GCY1_CAEEL/889-1077----ESNGKPSLIHL..TNDAHSLLT..THYPNQYETSSR.GEVIIK........G....K............GVMETFW
CYAA_SCHPO/1323-1519----VSVADGGQIAV..SAEVVSVLNQLDSETMSSEKTNV.NEMEVR........A.................LKQIGYI
GCYA1_BOVIN/473-660----ESCSVPRKINV..SPTTYRLLK....DCPGFVFTPR.SREELPPNFPSDIPG....................ICHF
ADCY8_HUMAN/973-1172----DSTGVSGRIQV..PEETYLILK.....DQGFAFDYR.GEIYVK........GISEQE............GKIKTYF
GCYB1_BOVIN/412-605----ETTGEKGKINV..SEYTYRCLMTPENSDPQFHLEHR.GPVSMK........G....K............KEPMQVW

PF05165

GCH3_AERPE/15-241LKAGIGIAPTARASLALAAEALHEIR---------------..SKIN---------------------------PGPLVV
GCH3_METJA/1-250LKAGIGIGRTAEDASNLADIGLEKIR---------------..GKLV---------------------------DKNVCT
GCH3_METTH/1-249LKAGIGKAPTAEKAANLADLALEEIR---------------..GGFT---------------------------YDLVHV
GCH32_HALSA/1-253FQVGVGHGDTPHDAGADAKHALETCR---------------ATGARV---------------------------HGPWTT

PF00990

B2NCU3_ECOLX/273-426---
Q55906_SYNY3/600-758---
Y4LL_RHISN/399-555---
YEGE_ECOLI/682-839---
YTRP_BACSU/423-571---
P74658_SYNY3/110-271---
P74197_SYNY3/340-500---
P72790_SYNY3/288-449---
P72746_SYNY3/429-586---
YNEF_ECOLI/146-304---
YEAP_ECOLI/174-331---
Q56569_VIBAN/41-198---
YEAI_ECOLI/328-485---
PHY2_SYNY3/1100-1260---
P73011_SYNY3/292-453---
P97018_AERJA/254-407---
P72956_SYNY3/314-475---
Y1895_SYNY3/263-420---
YDEH_ECOLI/129-283---
P73036_SYNY3/149-310---
P74400_SYNY3/1150-1312---
YKOW_BACSU/372-530---
P72809_SYNY3/414-576---
Q49739_MYCLE/116-273---
P73272_SYNY3/180-338---
GMR_ECOLI/237-391---
P72747_SYNY3/273-430---
Q55955_SYNY3/706-867---
DOSC_ECOLI/295-452---
O33908_9GAMM/333-502---
Q55414_SYNY3/653-814---
YDAK_BACSU/132-281---
YCDT_ECOLI/282-439---
YHCK_BACSU/192-351---
Q55576_SYNY3/795-953---
P72748_SYNY3/162-319---
CSRD_ECOLI/224-381---
PLED_CAUCR/289-448---
O32949_MYCLE/393-551---
ADRA_ECOLI/210-366---
PHY2_SYNY3/431-592---
YEDQ_ECOLI/398-557---
P72843_SYNY3/410-567---
YEAJ_ECOLI/344-495---
P73380_SYNY3/304-462---
Y1389_MYCBO/184-339---
YREP_STRAM/29-178---
YFIN_ECOLI/249-405---
P73713_SYNY3/801-959---

PF00211

ADCY1_BOVIN/296-480IVP
CYAA_STRCO/182-373LTR
CYAG_DICDI/387-572LMG
GCYB2_RAT/399-582LIQ
CYAA_DICDI/1180-1356LKG
GUC2C_HUMAN/815-1002LTG
CYAA_ANACY/311-501EVK
ADCY9_MOUSE/385-573ISG
ADCY3_RAT/310-494IIA
ADCY3_RAT/914-1121LKG
GCYH_DROME/457-647LES
ADCY1_BOVIN/862-1059LEG
CYAA_STIAU/221-410TPR
CYAA_TRYEQ/94-307LNA
ANPRA_HUMAN/867-1053LLG
ADCY2_HUMAN/878-1078VNT
GCY1_CAEEL/889-1077VHG
CYAA_SCHPO/1323-1519IHN
GCYA1_BOVIN/473-660LEA
ADCY8_HUMAN/973-1172LLG
GCYB1_BOVIN/412-605FLS

PF05165

GCH3_AERPE/15-241KAQ
GCH3_METJA/1-250LKQ
GCH3_METTH/1-249MKE
GCH32_HALSA/1-253ADD

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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