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390  structures 9362  species 0  interactions 91630  sequences 986  architectures

Clan: PIN (CL0280)

Summary

PIN domain superfamily Add an annotation

This superfamily contains a variety of nuclease enzymes, including PIN domains and the FLAP exonucleases.

This clan contains 27 families and the total number of domains in the clan is 91630. The clan was built by A Bateman.

Literature references

  1. Matelska D, Steczkiewicz K, Ginalski K;, Nucleic Acids Res. 2017;45:6995-7020.: Comprehensive classification of the PIN domain-like superfamily. PUBMED:28575517 EPMC:28575517
  2. Glavan F, Behm-Ansmant I, Izaurralde E, Conti E; , EMBO J. 2006;25:5117-5125.: Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. PUBMED:17053788 EPMC:17053788
  3. Glavan F, Behm-Ansmant I, Izaurralde E, Conti E; , EMBO J. 2006;25:5117-5125.: Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex. PUBMED:17053788 EPMC:17053788
  4. Anantharaman V, Aravind L; , RNA Biol. 2006; [Epub ahead of print]: The NYN Domains: Novel Predicted RNAses with a PIN Domain-Like Fold. PUBMED:17114934 EPMC:17114934

Members

This clan contains the following 27 member families:

5_3_exonuc_N DUF1308 DUF188 DUF4411 DUF5615 DUF5616 Fcf1 Mut7-C NYN NYN_YacP PIN PIN7 PIN_10 PIN_11 PIN_12 PIN_2 PIN_3 PIN_4 PIN_5 PIN_6 PIN_8 PIN_9 PRORP RNase_Zc3h12a RNase_Zc3h12a_2 XPG_N XRN_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PIN (PF01850) 19626 (21.4%) View
5_3_exonuc_N (PF02739) 11311 (12.3%) View
NYN (PF01936) 10788 (11.8%) View
XPG_N (PF00752) 8571 (9.4%) View
PIN_4 (PF13638) 8559 (9.3%) View
XRN_N (PF03159) 5007 (5.5%) View
PIN_3 (PF13470) 3718 (4.1%) View
Fcf1 (PF04900) 3610 (3.9%) View
DUF188 (PF02639) 3286 (3.6%) View
RNase_Zc3h12a (PF11977) 2991 (3.3%) View
NYN_YacP (PF05991) 2899 (3.2%) View
Mut7-C (PF01927) 2091 (2.3%) View
PIN_6 (PF17146) 1960 (2.1%) View
DUF5615 (PF18480) 1767 (1.9%) View
continued
Pfam family Num. domains Alignment
PRORP (PF16953) 1431 (1.6%) View
DUF1308 (PF07000) 1056 (1.2%) View
DUF4411 (PF14367) 432 (0.5%) View
PIN_12 (PF16289) 398 (0.4%) View
PIN_11 (PF18479) 330 (0.4%) View
PIN_10 (PF18478) 315 (0.3%) View
PIN7 (PF18475) 289 (0.3%) View
PIN_9 (PF18477) 283 (0.3%) View
PIN_8 (PF18476) 271 (0.3%) View
PIN_2 (PF10130) 242 (0.3%) View
DUF5616 (PF18481) 239 (0.3%) View
PIN_5 (PF08745) 126 (0.1%) View
RNase_Zc3h12a_2 (PF14626) 34 (0.0%) View
Total: 27 Total: 91630 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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