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929  structures 4080  species 5  interactions 40864  sequences 1227  architectures

Clan: Transthyretin (CL0287)


Transthyretin superfamily Add an annotation

This clan unifies several SCOP superfamilies that all share a 7 stranded beta sandwich fold.

This clan contains 13 families and the total number of domains in the clan is 40864. The clan was built by A Bateman.


This clan contains the following 13 member families:

CarboxypepD_reg Cna_B Dioxygenase_C DUF1416 DUF2012 DUF2606 DUF3823 DUF4480 FctA fn3_3 PEGA phage_tail_N Transthyretin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cna_B (PF05738) 13573 (33.2%) View
DUF4480 (PF13715) 11370 (27.8%) View
CarboxypepD_reg (PF13620) 6052 (14.8%) View
Dioxygenase_C (PF00775) 2905 (7.1%) View
Transthyretin (PF00576) 1803 (4.4%) View
FctA (PF12892) 1757 (4.3%) View
PEGA (PF08308) 1445 (3.5%) View
phage_tail_N (PF08400) 1004 (2.5%) View
fn3_3 (PF14686) 306 (0.7%) View
DUF2012 (PF09430) 303 (0.7%) View
DUF1416 (PF07210) 209 (0.5%) View
DUF3823 (PF12866) 92 (0.2%) View
DUF2606 (PF10794) 45 (0.1%) View
Total: 13 Total: 40864 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families
Transthyretin Transthyretin
Cna_B Molybdopterin
Dioxygenase_C Dioxygenase_C


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...