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1185  structures 2407  species 18  interactions 26843  sequences 1069  architectures

Clan: Transthyretin (CL0287)


Transthyretin superfamily Add an annotation

This clan unifies several SCOP superfamilies that all share a 7 stranded beta sandwich fold.

This clan contains 16 families and the total number of domains in the clan is 26843. The clan was built by A Bateman.


This clan contains the following 16 member families:

CarbopepD_reg_2 CarboxypepD_reg Dioxygenase_C DUF1416 DUF2012 DUF2606 DUF3823 DUF3869 fn3_3 GramPos_pilinBB MetallophosN PEGA phage_tail_N SdrD_B Transthyretin TTR-52

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CarbopepD_reg_2 (PF13715) 10293 (38.3%) View
CarboxypepD_reg (PF13620) 6133 (22.8%) View
Dioxygenase_C (PF00775) 2473 (9.2%) View
SdrD_B (PF17210) 1765 (6.6%) View
PEGA (PF08308) 1623 (6.0%) View
TTR-52 (PF01060) 1296 (4.8%) View
Transthyretin (PF00576) 1182 (4.4%) View
fn3_3 (PF14686) 864 (3.2%) View
DUF2012 (PF09430) 553 (2.1%) View
MetallophosN (PF16371) 192 (0.7%) View
GramPos_pilinBB (PF16569) 177 (0.7%) View
DUF1416 (PF07210) 174 (0.6%) View
DUF3823 (PF12866) 79 (0.3%) View
phage_tail_N (PF08400) 21 (0.1%) View
DUF3869 (PF12985) 14 (0.1%) View
DUF2606 (PF10794) 4 (0.0%) View
Total: 16 Total: 26843 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 18 interactions for this clan. More...

Interacting families
CarboxypepD_reg CarboxypepD_reg
Cohesin CarboxypepD_reg
Dioxygenase_C Dioxygenase_C
Dioxygenase_N Dioxygenase_C
DUF3823 DUF3823
DUF3869 DUF3870
fn3_3 CBM-like
PCDO_beta_N Dioxygenase_C
Peptidase_M14 CarboxypepD_reg
RhgB_N fn3_3
Transthyretin Lipocalin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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