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1506  structures 8189  species 40  interactions 110317  sequences 3599  architectures

Clan: Transthyretin (CL0287)

Summary

Transthyretin superfamily Add an annotation

This clan unifies several SCOP superfamilies that all share a 7 stranded beta sandwich fold.

This clan contains 33 families and the total number of domains in the clan is 110317. The clan was built by A Bateman.

Members

This clan contains the following 33 member families:

CarbopepD_reg_2 CarboxypepD_reg Cna_B CooC_C Dioxygenase_C DUF1416 DUF2012 DUF2606 DUF3823 DUF3869 DUF4139 DUF4198 DUF4458 DUF5300 FctA Fimbrillin_C fn3_3 GramPos_pilinD1 GramPos_pilinD3 Lipase_C MetallophosN PapC_C PEGA phage_tail_N Pollen_Ole_e_I PUD SdrD_B SpaA T6_Ig_like T6SS-SciN Transthyretin TTR-52 VHL

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CarbopepD_reg_2 (PF13715) 40737 (36.9%) View
CarboxypepD_reg (PF13620) 17559 (15.9%) View
SpaA (PF17802) 9085 (8.2%) View
Dioxygenase_C (PF00775) 7988 (7.2%) View
SdrD_B (PF17210) 4744 (4.3%) View
PEGA (PF08308) 3810 (3.5%) View
Transthyretin (PF00576) 3676 (3.3%) View
Cna_B (PF05738) 2673 (2.4%) View
TTR-52 (PF01060) 2505 (2.3%) View
Pollen_Ole_e_I (PF01190) 2432 (2.2%) View
DUF4139 (PF13598) 2141 (1.9%) View
DUF4198 (PF10670) 1870 (1.7%) View
fn3_3 (PF14686) 1702 (1.5%) View
PapC_C (PF13953) 1595 (1.4%) View
PUD (PF03714) 1382 (1.3%) View
T6SS-SciN (PF12790) 1142 (1.0%) View
DUF2012 (PF09430) 1051 (1.0%) View
continued
Pfam family Num. domains Alignment
FctA (PF12892) 1024 (0.9%) View
DUF1416 (PF07210) 680 (0.6%) View
MetallophosN (PF16371) 631 (0.6%) View
VHL (PF01847) 520 (0.5%) View
GramPos_pilinD1 (PF16555) 392 (0.4%) View
DUF3823 (PF12866) 285 (0.3%) View
Fimbrillin_C (PF15495) 202 (0.2%) View
CooC_C (PF15976) 154 (0.1%) View
Lipase_C (PF18067) 134 (0.1%) View
phage_tail_N (PF08400) 69 (0.1%) View
DUF4458 (PF14660) 54 (0.0%) View
DUF3869 (PF12985) 25 (0.0%) View
GramPos_pilinD3 (PF16570) 22 (0.0%) View
T6_Ig_like (PF18002) 17 (0.0%) View
DUF2606 (PF10794) 12 (0.0%) View
DUF5300 (PF17224) 4 (0.0%) View
Total: 33 Total: 110317 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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