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35  structures 3566  species 5  interactions 11834  sequences 91  architectures

Clan: KNTase_C (CL0291)


Nucleotidyltransferase substrate binding domain Add an annotation

This alpha helical domain is found associated with a variety of nucleotidyltransferase domains.

This clan contains 8 families and the total number of domains in the clan is 11834. The clan was built by A Bateman.


This clan contains the following 8 member families:

DUF294_C DUF4145 DUF86 GlnD_UR_UTase HEPN KNTase_C NTase_sub_bind PaREP1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GlnD_UR_UTase (PF08335) 5858 (49.5%) View
DUF86 (PF01934) 1619 (13.7%) View
HEPN (PF05168) 1339 (11.3%) View
DUF294_C (PF10335) 1001 (8.5%) View
DUF4145 (PF13643) 970 (8.2%) View
PaREP1 (PF05942) 500 (4.2%) View
NTase_sub_bind (PF08780) 469 (4.0%) View
KNTase_C (PF07827) 78 (0.7%) View
Total: 8 Total: 11834 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families
NTase_sub_bind NTase_sub_bind
KNTase_C NTP_transf_2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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