This clan includes an N-terminal domain from several vesicle transport proteins that are related to Vps51.
This clan contains 18 families and the total number of domains in the clan is 24846. The clan was built by A Bateman.
This clan contains the following 18 member families:COG2 COG5 COG6 Dor1 Dsl1_N Exo70 Exo84_C Sec15 Sec3_C Sec3_C_2 Sec5 Sec6 Sec8_exocyst Vps51 Vps52 Vps53_N Vps54_N Zw10
Below is a listing of the unique domain organisations or architectures from this clan. More...
The graphic that is shown by default represents the longest sequence with a given architecture. Each row contains the following information:
- the number of sequences which exhibit this architecture
a textual description of the architecture, e.g. Gla, EGF x 2, Trypsin.
This example describes an architecture with one
Gladomain, followed by two consecutive
EGFdomains, and finally a single
- a link to the page in the Pfam site showing information about the sequence that the graphic describes
- the UniProt description of the protein sequence
- the number of residues in the sequence
- the Pfam graphic itself.
Note that you can see the family page for a particular domain by
clicking on the graphic. You can also choose to see all sequences which
have a given architecture by clicking on the
in each row.
Finally, because some families can be found in a very large number of architectures, we load only the first fifty architectures by default. If you want to see more architectures, click the button at the bottom of the page to load the next set.
Loading domain graphics...
The table below shows the number of occurrences of each domain throughout the sequence database. More...
In brackets beside each number is the percentage of the total number of sequence hits for the clan that are represented by this domain. The rightmost column provides a link to the alignments tab for each domain. Finally, the last row in the table provides a link to the HTML representation of the alignment for the seed alignments for all members of this clan.
Please note: the clan alignment can be extremely large and the resulting HTML file is often too large to be rendered by web-browsers. Please consider downloading the alignment (by right-clicking the link) rather than viewing it in your browser.
|Pfam family||Num. domains||Alignment|
|Exo70 (PF03081)||3612 (14.5%)||View|
|Vps51 (PF08700)||3112 (12.5%)||View|
|Sec6 (PF06046)||1871 (7.5%)||View|
|Sec3_C (PF09763)||1689 (6.8%)||View|
|Vps52 (PF04129)||1597 (6.4%)||View|
|Vps53_N (PF04100)||1414 (5.7%)||View|
|Sec15 (PF04091)||1414 (5.7%)||View|
|Dor1 (PF04124)||1367 (5.5%)||View|
|COG6 (PF06419)||1289 (5.2%)||View|
|Exo84_C (PF16528)||1250 (5.0%)||View|
|Vps54_N (PF10475)||1169 (4.7%)||View|
|Sec5 (PF15469)||1134 (4.6%)||View|
|COG2 (PF06148)||1057 (4.3%)||View|
|Sec8_exocyst (PF04048)||1049 (4.2%)||View|
|Zw10 (PF06248)||892 (3.6%)||View|
|COG5 (PF10392)||891 (3.6%)||View|
|Dsl1_N (PF11988)||36 (0.1%)||View|
|Sec3_C_2 (PF15278)||3 (0.0%)||View|
|Total: 18||Total: 24846||Clan alignment|
Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.
This diagram shows the relationships between members of this clan. More...
Relationships between families in a clan are determined using HHsearch. Families are deemed to be closely related if their E-value is less than 10-3 and these relationships are shown with a solid line. Less closely related family pairs, with an E-value of between 10-3 and 10-1, are shown with a dashed line.
The E-value for each pair of closely or partially related families is shown next to the line linking the families. You can see the information regarding a Pfam family by clicking on the family box.