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69  structures 19970  species 4  interactions 91908  sequences 115  architectures

Clan: Peptidase_SF (CL0299)


Peptidase clan SF Add an annotation

This clan includes the peptidase S24 and S26 families. These families adopt a mainly beta fold. Members of the family S24 have an additional C-terminal domain containing a bundle of three helices presumably important for binding DNA.

This clan contains 3 families and the total number of domains in the clan is 91908. The clan was built by J Mistry and N Rawlings.

Literature references

  1. Luo Y, Pfuetzner RA, Mosimann S, Paetzel M, Frey EA, Cherney M, Kim B, Little JW, Strynadka NC; , Cell. 2001;106:585-594.: Crystal structure of LexA: a conformational switch for regulation of self-cleavage. PUBMED:11551506 EPMC:11551506
  2. Paetzel M, Chernaia M, Strynadka N, Tschantz W, Cao G, Dalbey RE, James MN; , Proteins. 1995;23:122-125.: Crystallization of a soluble, catalytically active form of Escherichia coli leader peptidase. PUBMED:8539246 EPMC:8539246


This clan contains the following 3 member families:

Peptidase_S24 Peptidase_S26 Phage_CI_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Peptidase_S24 (PF00717) 78889 (85.8%) View
Peptidase_S26 (PF10502) 11639 (12.7%) View
Phage_CI_C (PF16452) 1380 (1.5%) View
Total: 3 Total: 91908 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families
Peptidase_S24 Peptidase_S24
Peptidase_S26 Peptidase_S24


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...