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41  structures 5337  species 8  interactions 7590  sequences 216  architectures

Clan: TAT (CL0300)


Twin-Arginine Translocation Motif Add an annotation

This motif is found in a wide range of secreted proteins. It is named after the conserved pair of arginines that is followed by a hydrophobic stretch.

This clan contains 3 families and the total number of domains in the clan is 7590. The clan was built by A Bateman.

Literature references

  1. Berks BC; , Mol Microbiol. 1996;22:393-404.: A common export pathway for proteins binding complex redox cofactors?. PUBMED:8939424 EPMC:8939424
  2. Berks BC, Sargent F, Palmer T; , Mol Microbiol. 2000;35:260-274.: The Tat protein export pathway. PUBMED:10652088 EPMC:10652088


This clan contains the following 3 member families:

CytB6-F_Fe-S TAT_signal UCR_Fe-S_N

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
TAT_signal (PF10518) 4845 (63.8%) View
UCR_Fe-S_N (PF10399) 2309 (30.4%) View
CytB6-F_Fe-S (PF08802) 436 (5.7%) View
Total: 3 Total: 7590 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 8 interactions for this clan. More...

Interacting families
Apocytochr_F_C CytB6-F_Fe-S
CytB6-F_Fe-S Cytochrom_B_N_2
Cytochrom_B_N_2 CytB6-F_Fe-S
Cytochrom_C1 UCR_Fe-S_N
UCR_Fe-S_N Cytochrom_B_N_2


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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