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24  structures 1600  species 2  interactions 2445  sequences 40  architectures

Clan: PTH2 (CL0305)


Peptidyl-tRNA hydrolase II superfamily Add an annotation

This clan includes Peptidyl-tRNA hydrolase II as well as a large family of uncharacterised proteins called DUF2000. A structure for DUF2000 shows a similar structure to PTH2. It is not clear if the DUF2000 family are also Peptidyl-tRNA hydrolases. Both families contain a conserved positively charged residue close to the amino terminus that may be part of the active site.

This clan contains 2 families and the total number of domains in the clan is 2445. The clan was built by A Bateman.


This clan contains the following 2 member families:

DUF2000 PTH2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PTH2 (PF01981) 1943 (79.5%) View
DUF2000 (PF09391) 502 (20.5%) View
Total: 2 Total: 2445 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 2 interactions for this clan. More...

Interacting families
DUF2000 DUF2000


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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