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247  structures 1655  species 5  interactions 11292  sequences 280  architectures

Clan: Multiheme_cytos (CL0317)


Multiheme cytochrome superfamily Add an annotation

This family includes cytochromes that contain multiple CxxCH motifs.

This clan contains 11 families and the total number of domains in the clan is 11292. The clan was built by P Coggill.


This clan contains the following 11 member families:

CytoC_RC Cytochrom_c3_2 Cytochrom_C552 Cytochrom_CIII Cytochrom_NNT Cytochrome_C554 Cytochrome_C7 GSu_C4xC__C2xCH Multi-haem_cyto NapB Paired_CXXCH_1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cytochrom_NNT (PF03264) 2644 (23.4%) View
Multi-haem_cyto (PF13447) 1428 (12.6%) View
Paired_CXXCH_1 (PF09699) 1252 (11.1%) View
Cytochrom_C552 (PF02335) 1136 (10.1%) View
NapB (PF03892) 1044 (9.2%) View
Cytochrom_c3_2 (PF14537) 1009 (8.9%) View
Cytochrome_C7 (PF14522) 1003 (8.9%) View
Cytochrome_C554 (PF13435) 858 (7.6%) View
Cytochrom_CIII (PF02085) 410 (3.6%) View
GSu_C4xC__C2xCH (PF09698) 404 (3.6%) View
CytoC_RC (PF02276) 104 (0.9%) View
Total: 11 Total: 11292 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families
Cytochrom_CIII Cytochrom_CIII
Cytochrom_NNT Cytochrom_C552
Cytochrom_C552 Cytochrom_C552


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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