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309  structures 1324  species 22  interactions 6379  sequences 289  architectures

Clan: Multiheme_cytos (CL0317)


Multiheme cytochrome superfamily Add an annotation

This family includes cytochromes that contain multiple CxxCH motifs.

This clan contains 15 families and the total number of domains in the clan is 6379. The clan was built by P Coggill.


This clan contains the following 15 member families:

C_GCAxxG_C_C CytoC_RC Cytochrom_c3_2 Cytochrom_C552 Cytochrom_CIII Cytochrom_NNT Cytochrome_C554 Cytochrome_C7 Cytochrome_cB GSu_C4xC__C2xCH Multi-haem_cyto NapB Paired_CXXCH_1 zf-3CxxC zf-3CxxC_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Paired_CXXCH_1 (PF09699) 1089 (17.1%) View
Cytochrome_C554 (PF13435) 769 (12.1%) View
C_GCAxxG_C_C (PF09719) 753 (11.8%) View
Cytochrom_NNT (PF03264) 735 (11.5%) View
Cytochrome_C7 (PF14522) 497 (7.8%) View
zf-3CxxC (PF13695) 477 (7.5%) View
Cytochrom_CIII (PF02085) 413 (6.5%) View
Cytochrom_C552 (PF02335) 339 (5.3%) View
Cytochrom_c3_2 (PF14537) 317 (5.0%) View
NapB (PF03892) 245 (3.8%) View
GSu_C4xC__C2xCH (PF09698) 215 (3.4%) View
Multi-haem_cyto (PF13447) 181 (2.8%) View
zf-3CxxC_2 (PF17180) 158 (2.5%) View
Cytochrome_cB (PF11783) 109 (1.7%) View
CytoC_RC (PF02276) 82 (1.3%) View
Total: 15 Total: 6379 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 22 interactions for this clan. More...

Interacting families
CytoC_RC Photo_RC
Cytochrom_c3_2 Cytochrom_c3_2
Cytochrom_C552 Cytochrom_C552
Cytochrom_CIII Cytochrom_CIII
Cytochrom_NNT Cytochrom_C552
Cytochrome_C554 Cytochrome_cB
Cytochrome_C7 Cytochrome_C7
FAD_binding_2 Cytochrom_c3_2
Fe_hyd_SSU Cytochrom_CIII
Fer4 Cytochrom_CIII
Molybdop_Fe4S4 NapB
Molybdopterin NapB
Molydop_binding NapB
Multi-haem_cyto Multi-haem_cyto
NapB Molybdop_Fe4S4


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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