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235  structures 9033  species 7  interactions 91149  sequences 366  architectures

Clan: RND_permease (CL0322)


RND permease superfamily Add an annotation

Different members of the RND superfamily have been shown to transport hydrophobic drugs, fatty acids, bile salts, organic solvents, heavy metals, autoinducers and lipooligosaccharides in bacteria [1].

This clan contains 5 families and the total number of domains in the clan is 91149. The clan was built by A Bateman.

Literature references

  1. Tseng TT, Gratwick KS, Kollman J, Park D, Nies DH, Goffeau A, Saier MH Jr; , J Mol Microbiol Biotechnol. 1999;1:107-125.: The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. PUBMED:10941792 EPMC:10941792


This clan contains the following 5 member families:

ACR_tran MMPL Patched SecD_SecF Sterol-sensing

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ACR_tran (PF00873) 39964 (43.8%) View
MMPL (PF03176) 25496 (28.0%) View
SecD_SecF (PF02355) 15736 (17.3%) View
Patched (PF02460) 7238 (7.9%) View
Sterol-sensing (PF12349) 2715 (3.0%) View
Total: 5 Total: 91149 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 7 interactions for this clan. More...

Interacting families
ACR_tran ACR_tran
HlyD_2 ACR_tran
Sec_GG SecD_SecF
SecD_SecF Sec_GG


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...