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343  structures 85  species 11  interactions 98  sequences 24  architectures

Clan: Reo_sigma (CL0326)


Virus attachment protein superfamily Add an annotation

This superfamily includes virus attachment proteins that share a common beta sandwich domain.

This clan contains 4 families and the total number of domains in the clan is 98. The clan was built by A Bateman.

Literature references

  1. Schelling P, Guglielmi KM, Kirchner E, Paetzold B, Dermody TS, Stehle T; , J Biol Chem. 2007;282:11582-11589.: The reovirus sigma1 aspartic acid sandwich: a trimerization motif poised for conformational change. PUBMED:17303562 EPMC:17303562
  2. Stehle T, Dermody TS; , Rev Med Virol. 2003;13:123-132.: Structural evidence for common functions and ancestry of the reovirus and adenovirus attachment proteins. PUBMED:12627395 EPMC:12627395
  3. Chappell JD, Prota AE, Dermody TS, Stehle T; , EMBO J. 2002;21:1-11.: Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiber. PUBMED:11782420 EPMC:11782420


This clan contains the following 4 member families:

Adeno_knob Caudo_bapla_RBP Reo_sigma1 Reo_sigmaC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Adeno_knob (PF00541) 56 (57.1%) View
Caudo_bapla_RBP (PF08931) 39 (39.8%) View
Reo_sigmaC (PF04582) 2 (2.0%) View
Reo_sigma1 (PF01664) 1 (1.0%) View
Total: 4 Total: 98 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 11 interactions for this clan. More...

Interacting families
Adeno_knob Adeno_knob
Caudo_bapla_RBP Caudo_bapla_RBP
Reo_sigma1 Reo_sigma1
Reo_sigmaC Reo_sigmaC
Sushi Adeno_knob
V-set Adeno_knob


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...