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2  structures 1078  species 5  interactions 9854  sequences 275  architectures

Clan: AVL9 (CL0330)


Late secretory pathway transport machinery Add an annotation

Members of this clan are involved in vesicle formation/trafficking.

This clan contains 5 families and the total number of domains in the clan is 9854. The clan was built by A Bateman.

Literature references

  1. Harsay E, Schekman R; , Mol Biol Cell. 2007;18:1203-1219.: Avl9p, a member of a novel protein superfamily, functions in the late secretory pathway. PUBMED:17229886 EPMC:17229886
  2. Allaire PD, Ritter B, Thomas S, Burman JL, Denisov AY, Legendre-Guillemin V, Harper SQ, Davidson BL, Gehring K, McPherson PS;, J Neurosci. 2006;26:13202-13212.: Connecdenn, a novel DENN domain-containing protein of neuronal clathrin-coated vesicles functioning in synaptic vesicle endocytosis. PUBMED:17182770 EPMC:17182770


This clan contains the following 5 member families:

Afi1 Avl9 DENN DUF2347 SPA

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DENN (PF02141) 5791 (58.8%) View
SPA (PF08616) 1471 (14.9%) View
Avl9 (PF09794) 1325 (13.4%) View
DUF2347 (PF09804) 708 (7.2%) View
Afi1 (PF07792) 559 (5.7%) View
Total: 5 Total: 9854 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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