Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
6  structures 1882  species 0  interactions 7823  sequences 33  architectures

Clan: EpsM (CL0331)


General secretion pathway protein M Add an annotation

These families are involved in the general secretory pathways of bacteria and are normally membrane-bound.

This clan contains 8 families and the total number of domains in the clan is 7823. The clan was built by P Coggill.


This clan contains the following 8 member families:

DUF2514 GspL_C HemX Phage_lysis PilN PilO T2SM T2SM_b

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Phage_lysis (PF03245) 1696 (21.7%) View
PilN (PF05137) 1587 (20.3%) View
HemX (PF04375) 1205 (15.4%) View
T2SM (PF04612) 1099 (14.0%) View
GspL_C (PF12693) 933 (11.9%) View
PilO (PF04350) 807 (10.3%) View
DUF2514 (PF10721) 309 (3.9%) View
T2SM_b (PF10741) 187 (2.4%) View
Total: 8 Total: 7823 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...