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64  structures 3362  species 3  interactions 8582  sequences 42  architectures

Clan: EpsM (CL0331)


General secretion pathway protein M Add an annotation

These families are involved in the general secretory pathways of bacteria and are normally membrane-bound.

This clan contains 8 families and the total number of domains in the clan is 8582. The clan was built by P Coggill.


This clan contains the following 8 member families:

DUF2514 GspL_C Phage_lysis PilN PilN_bio_d PilO T2SSM T2SSM_b

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PilN (PF05137) 2803 (32.7%) View
PilO (PF04350) 2276 (26.5%) View
T2SSM (PF04612) 1404 (16.4%) View
GspL_C (PF12693) 996 (11.6%) View
T2SSM_b (PF10741) 508 (5.9%) View
Phage_lysis (PF03245) 434 (5.1%) View
DUF2514 (PF10721) 135 (1.6%) View
PilN_bio_d (PF18222) 26 (0.3%) View
Total: 8 Total: 8582 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
GspL_C GspL_C
PilO PilO


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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