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536  structures 4456  species 10  interactions 18260  sequences 93  architectures

Clan: THBO-biosyn (CL0334)


Tetrahydrobiopterin biosynthesis-like enzyme superfamily Add an annotation

The families in this clan bind purine or ptein in topologically similar sites between subunits.

This clan contains 7 families and the total number of domains in the clan is 18260. The clan was built by P Coggill.


This clan contains the following 7 member families:

FolB GCHY-1 GTP_cyclohydroI PTPS QueF QueF_N Uricase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GTP_cyclohydroI (PF01227) 4540 (24.9%) View
FolB (PF02152) 4144 (22.7%) View
PTPS (PF01242) 3925 (21.5%) View
QueF (PF14489) 2059 (11.3%) View
Uricase (PF01014) 1939 (10.6%) View
GCHY-1 (PF02649) 996 (5.5%) View
QueF_N (PF14819) 657 (3.6%) View
Total: 7 Total: 18260 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 10 interactions for this clan. More...

Interacting families
FolB FolB
GTP_cyclohydroI GFRP
QueF QueF
QueF_N QueF
Uricase Uricase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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