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1797  structures 94  species 118  interactions 3282  sequences 58  architectures

Clan: MHC (CL0343)

Summary

MHC antigen-recognition domain Add an annotation

This superfamily includes all the Class I-related antigen-recognition domain families.

This clan contains 6 families and the total number of domains in the clan is 3282. The clan was built by P Coggill.

Members

This clan contains the following 6 member families:

M157 MHC_I MHC_I_2 MHC_I_3 MHC_II_alpha MHC_II_beta

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
MHC_I (PF00129) 1847 (56.3%) View
MHC_II_beta (PF00969) 600 (18.3%) View
MHC_I_3 (PF16497) 406 (12.4%) View
MHC_II_alpha (PF00993) 392 (11.9%) View
MHC_I_2 (PF14586) 36 (1.1%) View
M157 (PF11624) 1 (0.0%) View
Total: 6 Total: 3282 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 118 interactions for this clan. More...

Interacting families
A B
C1-set MHC_I
MHC_II_alpha
MHC_II_beta
Corona_M MHC_I
Cytomega_US3 MHC_I
DUF1968 MHC_I
MHC_II_beta
Hemagglutinin MHC_I
ig MHC_I
Lectin_C MHC_I
M157 Ly49
MHC_I 14-3-3
Actin
Adeno_GP19K
Arena_glycoprot
Arm
ATP-synt_A
C1-set
Corona_M
COX2_TM
Cytomega_US3
DUF1968
EBV-NA3
F-protein
Flu_M1
Flu_NP
Flu_PA
Flu_PB1
Gag_p17
Gag_p24
Gla
Globin
GP120
HCV_NS4b
Hemagglutinin
Hepatitis_core
Herpes_LMP2
Herpes_UL69
Herpes_UL82_83
Histone
ig
Ig_2
Ig_3
Integrase_Zn
Lectin_C
LSM
MAGE
MHC_I
MHC_II_alpha
MLANA
Myelin_PLP
OATP
PA
Paramyxo_ncap
PB1-F2
Pcc1
Peptidase_A22B
Peptidase_S29
PNP_UDP_1
Pox_T4_C
RVT_1
Serum_albumin
Spike_rec_bind
SVA
Tax
TFR_dimer
Tubulin_C
UL40
V-set
Vif
WT1
MHC_I_2 MHC_I_2
MHC_II_alpha C1-set
Cytochrom_C
DNA_pol_B
Gag_p24
GTP_EFTU_D3
Hemagglutinin
Integrin_beta
MA-Mit
MHC2-interact
MHC_I
MHC_II_alpha
MHC_II_beta
MLANA
Myelin_MBP
Pyridoxal_deC
Stap_Strp_tox_C
Stap_Strp_toxin
TIM
Transferrin
V-set
MHC_II_beta C1-set
Cytochrom_C
DNA_pol_B
DUF1968
Gag_p24
GTP_EFTU_D3
Hemagglutinin
Integrin_beta
Lectin_C
MA-Mit
MHC2-interact
MHC_I
MHC_II_alpha
MHC_II_beta
MLANA
Myelin_MBP
Stap_Strp_tox_C
TIM
Transferrin
V-set
PA MHC_I
Stap_Strp_tox_C MHC_II_alpha
MHC_II_beta
V-set MHC_I
MHC_II_alpha
MHC_II_beta

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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