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91  structures 264  species 4  interactions 572  sequences 34  architectures

Clan: Aerolisin_ETX (CL0345)


Aerolysin/ETX pore-forming domain superfamily Add an annotation

This superfamily includes pore-forming venoms and toxins from bacteria, plants, insects and fish.

This clan contains 3 families and the total number of domains in the clan is 572. The clan was built by P Coggill.


This clan contains the following 3 member families:

Aerolysin BB_PF ETX_MTX2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ETX_MTX2 (PF03318) 354 (61.9%) View
Aerolysin (PF01117) 160 (28.0%) View
BB_PF (PF18063) 58 (10.1%) View
Total: 3 Total: 572 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families
Aerolysin Aerolysin
APT Aerolysin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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