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9  structures 5382  species 1  interaction 22116  sequences 103  architectures

Clan: Tetraspannin (CL0347)


Tetraspannin-like Add an annotation

This clan includes the tetraspanin family which contains four transmembrane regions. The CD20 family also has four transmembrane regions, but its members are not considered true tetraspanins as they lack nearly all of the key functional tetraspanin residues [1].

This clan contains 3 families and the total number of domains in the clan is 22116. The clan was built by J Mistry and RD Finn.

Literature references

  1. Hemler ME;, J Cell Biol. 2001;155:1103-1107.: Specific tetraspanin functions. PUBMED:11756464 EPMC:11756464


This clan contains the following 3 member families:

CD20 DUF4064 Tetraspannin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DUF4064 (PF13273) 13926 (63.0%) View
Tetraspannin (PF00335) 6735 (30.5%) View
CD20 (PF04103) 1455 (6.6%) View
Total: 3 Total: 22116 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families
Tetraspannin Tetraspannin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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