Sequence alignment for CL0353

PF00965

Q29AK5_DROPS/26-197DACSCM.P.SHPQTHFCK------ADY..VVQLRV....LRKSDTIDPG............KTTYKVHIKRTYKAT----
Q1RLX2_DANRE/24-203EACSCS.P.VHPQQAFCN------ADV..VIRAKV....VGKKEVDSGNDIYGNP....IKRIQYEIKQIKMFKGP----
A7SSJ2_NEMVE/18-205KACVCKMG.SHPQDKFCQ------ADF..VVRGRVESGPVEGYITYPPQSRGFRHWPKQRDVLVHVVMVTQIFKGA----
TIMP2_CAVPO/25-203DACSCS.P.VHPQQAFCN------ADV..VIRAKA....VSEKEVDSGNDIYGNP....IKRIQYEIKQIKMFKGP----
TIMP3_BOVIN/22-194EACTCS.P.SHPQDAFCN------SDI..VIRAKV....VGKKLLKEGPF..........GTMVYTIKQMKMYRGF----
A7SSJ1_NEMVE/20-204DDCICASPHGHPQDVFCS------SDY..ALRGLV....TSGPKKETIKIMQPPDKPLTRNVLSYIVEIREVYRGG----
Q9GPJ2_CRAGI/21-203HSCMCD.F.THPQNNFCS------ADF..VIKATI....VKEELKFGDESMGIPFP..LQKNYTVQFKKRDIFKGS----
TIMP1_MOUSE/23-199KACSCA.P.PHPQTAFCN------SDL..VIRAKF....MGSPEINETT...........LYQRYKIKMTKMLKGF----
TIMP4_RAT/28-207EACSCA.P.AHPQQHVCH------SAL..VIRAKI....SSEKVVPASEDPADTQ.....KMIRYEIKQIKMFKGF----
Q16IW9_AEDAE/30-198EACSCL.P.EHAQTAYCD------AEY..VIVAQV....LRKSNRKHND............NNVYKIAIKKEYKMS----
TIMP1_HUMAN/22-199RACTCV.P.PHPQTAFCN------SDL..VIRAKF....VGTPEVNQTT...........LYQRYEIKMTKMYKGF----
F6NH88_DANRE/71-248.ACSCS.P.EHPQQAYCN------ADV..VIRAKV....VGRKEVVTGNDAYGYP....IKMIRYDVKQLKMFKGP----
H2LU60_ORYLA/26-204EACSCS.P.AHPQQAVCN------SDV..VIRAKL....VGRQEVDAGNDIYGNT....IKRIKYDVKQIKMFKGP----
H2SZH2_TAKRU/30-202EGCSCA.L.THPQDAFCN------SDI..VIRAKV....VGKKLLRDGP.....F.....GTMRYTVKQMKMYKGF----
H2USP3_TAKRU/28-207EGCSCL.P.AHPQQLFCS------SEI..VIRAKI....SGEKIVSPSNNSSPYM.....KMIQYEIKMIKMFKGF----
H3C979_TETNG/26-206EACSCA.P.VHPQQAFCN------ADVGRVIRAKV....VGEQEVNSGNDIYGNP....IKRIQYEVKQVKMFKGP----
H3CWM8_TETNG/28-206EACSCS.P.AHPQQAFCN------ADV..VIRAKL....VERQEVDVGNDIYGNP....VKQIKFGVKQIKMFKGP----

PF01759

Q8WPD8_CIOIN/1602-1707-------------DEGCS......AKY--VYKVRV........IGVREDS.---------VFVNLDAVIEDVYRSG....
Q8I7P1_9CNID/1611-1718-------------GLFCT.....TYDY--AFKGKL........LIIDEED.---------QWLHLTFEVVEVYKES....
Q8MX24_ANCCA/29-132-------------KLLCQ......SQF--VTHAKV........TKKRIDG.---------YFIYYDLEHKEVYKPK....
Q5NKN5_CARRO/1605-1719-------------DRACV.....DHDY--VWKGTV........ESKRKEN.---------GFRYISFRVTSVFKEG..IE
CO3_EPTBU/1496-1605-------------GNACR......AEY--VFIIGV........TKVTKTA.---------SYININAALKTVLKKG....
CO3_LAMJA/1543-1654-------------EAACV....AGIDY--AYVGIV........DNRTEVG.---------SFVYYTVNIQTVIKSG....
Q9I933_CYPCA/1566-1681-------------RYACY...SPGVDY--AYVIKV........LNSSTDH.---------VFMYYTTLITDVLQTG...L
Q91741_XENLA/1554-1664-------------TFACY...SPRVVF--GYRVMV........ENIAEQD.---------AFIVYTARILEVLQRN....
Q76KI4_TRISC/1564-1675-------------DFACY...SPIVDY--AYTVRV........LNISSAG.---------SFDNYQVSIADRLKMS...N
Q9I932_CYPCA/1587-1697-------------EYACF...HTNIEY--AFEVIV........NSVTEES.---------NFMLYSATVTVVLRYT....
Q7SZG2_TAKRU/1574-1684-------------QHACF...IPTVDY--AYIVEV........FNISMKS.---------NFEVYETRLKDVLRTH....
Q4RHV3_TETNG/135-245-------------QHACF...VPTVDY--AYVVEV........LNVSMKS.---------NFELYEARVKDVLRNH....
Q70TF5_ONCMY/1595-1705-------------EHACY...SPTVDY--GFIVQV........ISMSVKS.---------NFELYTTNVTQVLRAT....
Q9IBG9_ORYLA/1588-1699-------------EHACF...YPVVDY--AYIVTV........NSVSLKS.---------NFELYKANIANVLKSS...G
Q076D6_CHICK/1536-1646-------------DFACY...SPRVDY--ALVVRV........LSQSEIG.---------AFVAFETEIKEVLLEG....
CO4A_HUMAN/1615-1725-------------KFACY...YPRVEY--GFQVKV........LREDSRA.---------AFRLFETKITQVLHFT....
Q62238_MOUSE/465-575-------------RFACY...YPRVEY--GFTVKV........LREDGRA.---------AFRLFESKITQVLHFR....
Q969A4_BRABE/1602-1713-------------EKACN.....DLDY--AFRVIV........MEVRQEG.---------SFDRISMIVESPIKKG....
Q8AYN9_CYPCA/1560-1672-------------NDMCK....ESMNY--AFKVLI........ESSEAGG.---------DFVTYKAKVKAVLMKG....
Q4SXM5_TETNG/1606-1718-------------SETCR....PQIRY--AYKVMV........KSSAAEG.---------DFMTYAATVVEVLKNS..DK
Q6VPV1_PIG/1548-1659-------------ETACK....PEIAY--VYKVKI........IAMTEES.---------AFVKYTASLLDVYKAG....
Q99KX9_MOUSE/254-364-------------EKACK....PETAY--AYKVRI........TSATEEN.---------VFVKYTATLLVTYKTG....
CO5_HUMAN/1550-1661-------------QTACK....PEIAY--AYKVSI........TSITVEN.---------VFVKYKATLLDIYKTG....
Q4SVH8_TETNG/1716-1828-------------TFACS.....SLHH--VFKVKV........ANVSQS..---------YYDSYEMEILQVIKLG....
A5PMP6_DANRE/1549-1662-------------AAVCN.....GLHH--AYRVKL........ISISQSH.---------.YYQYEMEIVQVIKEG....
Q9W6G1_PROAT/775-885-------------NEACD....PGRDY--VYKVKF........LAVNISA.---------SYDHYTAEILEVIKAG....
Q91588_9PIPI/1460-1570-------------NMGCA....PGVDF--VYKATL........TEVQPSD.---------NFDNYVMTIKKVIKQG....
VCO32_AUSSU/1522-1632-------------QKACA....PNVDY--VYKAKL........LRIEEKD.---------GNDIYVMDVLEVIKGG....
VCO3_NAJKA/1513-1623-------------EKACE....TNVDY--VYKTKL........LRIEEQD.---------GNDIYVMDVLEVIKQG....
Q90633_CHICK/1523-1633-------------DLACK....PGVDY--VYKVKV........VATEETP.---------SHDNYIMSILTVIKMG....
Q3L2T4_MACEU/1523-1632-------------EEACE....PGVDY--VYKVKV........DKIKQSD.---------SYDEYQMLIKQVIKSG....
CO3_RABIT/597-707-------------DKACE....PGLDY--VYKTKL........VQVERAD.---------DFDEYLMVVENTIKSG....
CO3_BOVIN/1532-1642-------------DKACE....PGVDY--VYKTRL........IQKKLED.---------DFDEYIMVIENIIKSG....
A6MK21_CALJA/94-204-------------DKACE....PGVDY--VYKTRL........VKIQLSN.---------DFDEYVMAIEQIIKSG....
CO3_RAT/1534-1644-------------DKACE....PGVDY--VYKTKL........TTIELSD.---------DFDEYIMTIEQVIKSG....
Q9DDV9_ONCMY/1553-1662-------------DKACE....SHMDY--VFKASM........VNATLES.---------YTDTYLMEIKMIIKEG....
Q98977_ONCMY/1484-1594-------------DKACE....AGMDY--VFKASL........VNATLES.---------YTDTYLMEIKRIIKEG....
Q3L5A8_GADMO/75-188-------------DKACD..AEVKIDY--VYKVTM........ESYVDHN.---------STDVYMMRINQVIKEG....
Q98TS6_ANAMI/1526-1643-------------AKVCETELNNKIDF--AYRVGL........EEFTDGL.---------STDIYKVRVLQVIKEG....
Q4S019_TETNG/1311-1428-------------AKACETQQFNKIDY--VYKVRV........QDFAEGL.---------STDIYTVQVLDVIKEG....
Q9IBH1_ORYLA/1522-1639-------------SKICESTESSKIEY--AYKVLV........EDVVQKP.---------SIDIYAMRVQDSIKEG....
Q4RJA3_TETNG/792-902-------------SNAKT.......DF--VYKVQV........DDFYEDL.---------STDVYTMSILESIKEG....
Q4RZT6_TETNG/1515-1632-------------AKSCETTPTSKIDF--VYKVRV........ERFTADL.---------STDVYSMRILEVIKEG....
CO3_ONCMY/1507-1621-------------DKACG....AGLDY--VYKATV........VDSKLTT.---------HTDTYTVKIDLVIKPG....
Q3MU73_DANRE/1522-1632-------------IKACE....PHLDY--IYKAKL........VKMDLKQ.---------DSDIYHMKVEKTVKEG....
Q9YIA6_CYPCA/1030-1140-------------NKACE....GGMDY--VYKATV........VGMNQTM.---------HSDIYDMKVEKVVKEG....
Q6UAQ6_CTEID/1510-1620-------------VKACE....AGMDY--VYKVTV........VGMDLAH.---------DSDIYHLKVDQVLKEG....
Q9YIA9_CYPCA/1513-1623-------------NRACE....AGMDY--VYKVKV........VGMDLKQ.---------DADIYDLEVEQVLKEG....
Q4S5G7_TETNG/453-556-------------NSFCK.....S.DF--VILGRV........TELTEEQ.---------ESGHALVTVEEILKDE..KM
O44344_STRPU/1565-1680-------------GTACA....SHSSY--ALKIRI........DEVEIKE.---------GFRICKFTVLNPIKTG....
A7SX91_NEMVE/256-359-------------AHFCI......SQH--VILARI........TKIRSNK.---------QRTVYYADVLAAYKGR....
Q4RGB2_TETNG/197-294-------------EHMCA......SEF--AFKTKI........KEVKRENR---------DRKVILHRRKKTLKAG....
A3KNP6_DANRE/185-282-------------DQMCA......SEF--AIKTKI........KEVKIDNL---------DRKVILQKRRKLVRAG....
Q32PN6_DANRE/181-278-------------DHMCA......SEF--AIKTKI........QEVKRENM---------DRKVTLQKKKRTIKMG....
Q6GZK1_ORYLA/191-288-------------ENICA......SEF--ALKAKI........KEVKQENM---------DRKVILQRRKRMVKQG....
Q3KQ69_XENLA/197-293-------------EHMCA......SDF--ALKVSI........REVKKEN.---------GDRKLLLRKKKALKKG....
SFRP5_HUMAN/195-293-------------EQMCS......SDF--VVKMRIKE......IKIENGD.---------RKLIGAQKKKKLLKPG....
Q4SKX3_TETNG/205-303-------------EHYCA......SDF--ALKMKIKE......VKKEKGD.---------RKLIAAQKKKKVLKLG....
SFRP1_MOUSE/200-296-------------EHLCA......SEF--ALRMKI........KEVKKEN.---------GDKKIVPKKKKPLKLG....
SFRP1_CHICK/200-296-------------EHLCA......SEF--ALKMTI........KEVKKEN.---------GDKVIIPRKRKALKLG....
A4IGU5_XENTR/180-278-------------QNYCS......SDF--ALKINIRS......VSTLEGD.---------VMVVPEARSRTVYKSK....
L8I1X6_9CETA/186-284-------------ETLCK......NDF--ALKIKV.KE.....ITYINRD.---------TKIILETKSKTIYKLN....
Q7ZXM6_XENLA/190-288-------------ENLCK......NDF--ALKIKV.KE.....IAYINGD.---------TKIIPETKGKTIYKLN....
Q32SK8_DANRE/445-554-------------KVFCN....AKYAY--AVKVRV........LGAHDKG.---------SHAEVDVKILKVLWDN....
Q0VEM1_MOUSE/517-624-------------KAFCG....MKYSY--VLKIKI........LSAHDKG.---------SHAEVNVKIKKVLKST....
Q4RSD5_TETNG/491-599-------------KLFCA....AEYDY--VLVVKV........MSAHDKG.---------SHAEVEVKVKKVLHQN....
Q4S5B2_TETNG/454-562-------------KLFCT....MNYAY--VLKVKV........LSAHDKG.---------SHAEVEVKVQKVLSQN....
Q2HJB6_BOVIN/340-444-------------SHFCN......SDL--VVTGMI........KSMVRGPG---------EGLTATVNVTGVYKTG....
Q3UIP2_MOUSE/353-457-------------SNFCS......SSL--VVTGTV........KTMVRGPG---------EGLTVTVSLLGVYKTG....
PCOC1_HUMAN/330-434-------------SNFCA......SSL--VVTATV........KSMVREPG---------EGLAVTVSLIGAYKTG....
Q7ZWR8_XENLA/379-484-------------SHYCA......NQF--VVTGTVNS......LTQGDSE.---------KSLLATVTIIKTFKVE....
Q66IT1_XENLA/372-477-------------SHYCA......NQF--VVTGTVNA......LTQGDSE.---------KSLLATVTIIKTYKVE....
Q1RMV2_BOVIN/310-413-------------SNYCS......SNF--VLAGTV........ITTIPRG.---------GSLHATVSIINIYKEG....
PCOC2_MOUSE/308-411-------------SNYCS......SNF--VLAGTV........ITTVTRG.---------GSLHATVSIISIYREG....
Q4S4Z9_TETNG/252-355-------------SNYCS......SNF--VITGTV........ITAVMRG.---------GSMYATVSIINVYKEG....
Q52L01_XENLA/302-405-------------SNYCS......SNF--VITGTI........ITTVSRG.---------GSVYATVSIINVYKEG....
SFRP4_HUMAN/188-289-------------ATYLS....KNYSY--VIHAKI........KAVQRSGC---------NEVTTVVDVKEIFKSS....
O08570_MESAU/127-229-------------TXFRN.....NYNY--VIRAKV........KEVKAKC.---------HDVTAVVEVKEILKAS....
Q32N13_XENLA/189-292-------------KTYLK....NNYNY--VIRAKV........KEVKVKC.---------HDATAIVEVKEILKSS....
Q9W6E0_DANRE/200-303-------------KTYSK....NNYNY--VIRARV........KEIRIRN.---------HDLSAIVEVKEVLKSS....
Q4S9P7_TETNG/197-299-------------.TYVK....NNYNY--VIRARV........KEVRNRG.---------LEPTAVVDVKEVLKSS....
X6R4H8_HUMAN/364-467-------------LHYCG......SDF--VFQARV........LGHHHQA.---------QETRYEVRIQLVYKNR....
A7SBN2_NEMVE/182-284-------------RRFCL......SDY--AIRARV........DSEVHKN.---------GHQQLRVRVSTRYKSG....
Q9NL28_CIOIN/535-642-------------AKYCK......MEY--AVMVRV........TGKIRIG.---------RRTSITYQVLRVFKRG....
Q95YK2_CIOSA/556-663-------------GKFCR......MGY--AVVVQV........TGKLTLR.---------RKTRFTLQLHKTYKRG....
A0A9Q8_MOLTE/181-286-------------KRFCR......KSI--VYEALV........ISVAEEG.---------EWIKYTIDVTKIRKKK....
A7SHI5_NEMVE/436-545-------------KRFCR......KDF--ALKVTVVR......VEKKLPN.---------SWVRATVNINTLFKRS....
UNC6_CAEEL/491-597-------------KKFCK......RDH--AVQMVV........VSREMVD.---------GWAKYKIVVESVFKRG....
Q0IGC3_AEDAE/141-257-------------NKFCK.....R.DY--AIMAKV.TGRTTSSNKHVPRD.---------.EVRFNLQVQTVFKSTNPLL
O96659_HIRME/495-600-------------VKYCK......RDY--AIHAQV........TSREIIG.---------EWAKFSVQVFSVFKKS....
Q4SF52_TETNG/899-1011-------------LFYLK.....NVSS--VLKVQV........RGMERSG.---------PWWQFSIAVQTVFREG....
Q0V9H1_XENTR/485-591-------------RKYCK......KDY--VLRAQL........LSMEKSG.---------EWWQFTATVLTVYRQR....
NET5_MOUSE/314-431-------------QRYCQ......QDY--VLHAQVSASSSQ..PSEAVGP.---------EWWRLAVHVLAVFKQR....
NET5_HUMAN/361-468-------------RRYCQ......QDH--VLRAQV........LASEAAGP---------AWQRLAVRVLAVYKQR....
Q52KG2_MOUSE/457-570-------------KKFCR......KDY--AVQVAV........GARGEARG---------SWTRFPVAVLAVFRSG....
K7CDB2_PANTR/488-594-------------KKYCK......KDY--AVQIHI........LKADKAG.---------DWWKFTVNIISVYKQG....
O42203_DANRE/487-595-------------KKYCK......KDF--AVQVHV........LKGDKAG.---------EWWKFTINIISVYKQG....
NET3_CHICK/465-571-------------KKYCK......KDY--VVQVNI........LEMETVA.---------NWAKFTINILSVYKCR....
Q32SK9_DANRE/482-590-------------KKYCK......KDY--AVQVSV........LDMETVG.---------DWAKFSVSLMSVYKSR....
Q9NFW6_BRAFL/441-548-------------KNYCK......SGY--VIQCSI........LSREILG.---------EWTKFTINVGTIFKRE....
Q59JG2_HEMPU/509-616-------------NKYCK......KDY--VLHAHV........LSREMED.---------EWVKFTVNVVTVYKRG....
Q1PHQ2_SACKO/484-590-------------NKYCK......KDY--AVQANI........LSREQTT.---------DWVKFTINVMTVYKKG....

PF00965

Q29AK5_DROPS/26-197-PEARRMLRDGRLATPNSDSM............CGIR.LDLG..K-VYIIA----G.RMP.....TLNVCSYYKEYTKMT
Q1RLX2_DANRE/24-203-DR.....HIDVVFTAPSSAV............CGVTNLDTNGKK-EYLIS----G.KAEANGKMHVTLCDLIMPWESMS
A7SSJ2_NEMVE/18-205-GLVSKAGKPVAKQPEEGNPLVHNVKIYADRSPCPGW.LRAG..T-DYLLA----G..LVDDGKLFISSCHWTSPWQQVT
TIMP2_CAVPO/25-203-EK.....DIEFIYTAPSSAV............CGVS.LDVGGKK-EYLIA----G.KAEGDGKMHITLCDFIVPWDTLS
TIMP3_BOVIN/22-194-TK...MPHVQYIHTEASESL............CGLK.LEVN.KY-QYLLT----G.RVY.DGKMYTGLCNFVERWDQLT
A7SSJ1_NEMVE/20-204-QIIRRTTGLQHRNTTLL..LPSEVRITTDDNACAAI.LPLN..T-EQLIA----G..YSDGARLEVFSCNWVEPWGNLT
Q9GPJ2_CRAGI/21-203-SLLGSSDTLVIKTSGTPWN.............CGET.FTLN..K-EYVIS----G..FVSDGEFFTNNCQWNPEYLTLE
TIMP1_MOUSE/23-199-KAVGNAADIRYAYTPVMESL............CGYAHKSQNRSE-EFLIT----G.RLR.NGNLHISACSFLVPWRTLS
TIMP4_RAT/28-207-EK...AKDIQYVYTPFDSSL............CGVK.LETNSQK-QYLLT----G.QILSDGKVFIHLCNYIEPWEDLS
Q16IW9_AEDAE/30-198-PRAQKMLKQGKLITPSTDSM............CGIQ.LEVN..Q-LYAIA----A.RDI.....HVGLCNFVRKYSDLT
TIMP1_HUMAN/22-199-QALGDAADIRFVYTPAMESV............CGYFHRSHNRSE-EFLIA----G.KLQ.DGLLHITTCSFVAPWNSLS
F6NH88_DANRE/71-248-NG.....EIDTIFTGPSSAL............CGVN.LESNGKQ-EYLIT----G.NLNSNGTLRINLCDYIESWESLS
H2LU60_ORYLA/26-204-SH.....DIDAVYTAPSSSL............CGVS.MDTTGKK-EYLIT----G.KLETDGTMHVTLCDFIDQWDAMT
H2SZH2_TAKRU/30-202-DK...VQHVQHIYTDASESL............CGVK.FDIN.KY-QYLIT----G.RVY.DDKVYTGLCNFNERWERLS
H2USP3_TAKRU/28-207-DK...AKDIQYVYTPVFSSL............CGVK.LDYNNKA-GYLLS----G.SMWRDGRISVGQCDLVESWDNLS
H3C979_TETNG/26-206-NQ.....DVEAVLTAPVSAV............CGVT.LDASGRK-EYLIS----G.KEEGGGRVHVTLCDYIMPWEALS
H3CWM8_TETNG/28-206-TQ.....DIEAIYTPPSSAM............CGVS.LQAN.GK-EYLIT----GGKLNADGTLHVTLCDFIELWESTS

PF01759

Q8WPD8_CIOIN/1602-1707.SDNVQNGTVRTFVIRND...------------CHASCRDT..DE.DLRLL.....-----RNNIPAKDTRLFKEGR..V
Q8I7P1_9CNID/1611-1718VTKKITKKTARIVYSKKIS..------------CDCPVFAGKIDR.HFLIM....G-----KDV........GLRGSSKV
Q8MX24_ANCCA/29-132..DRKIPIELFSWREKEN...------------CGVPDLEE..GK.EYLIG....G-----KVT.......DYGDGDLVI
Q5NKN5_CARRO/1605-1719QKQNILHTSKDLMVRDS....------------CSVADLDI..QQ.EYVIM....G-----RDG.AQFKDEDTGILLYRY
CO3_EPTBU/1496-1605MDQAINVGARRSFVIPMH...------------CGKN.LNVSPGD.IYLVM....G-----MHN.....AHWRNSDRTQY
CO3_LAMJA/1543-1654QDQAIQPKATRLFIVTRS...------------CDGR.LGMETPR.QYLLM....G-----RKG...ETKDRNDRFQ..Y
Q9I933_CYPCA/1566-1681LDSGIQKHATRQMILRLS...------------CDELELKK..EV.HYLIM....G-----QNDAISVLNNDGQHFR..Y
Q91741_XENLA/1554-1664SDEDIKPEDTRLFYQPMS...------------CK...MRLAKET.EYLIM....G-----QDG...VTKNEHGHIR..Y
Q76KI4_TRISC/1564-1675KDDDVKIGEVRHFLSQRS...------------CK...FQLKEGD.EYLVM....G-----QDG...TTSDTSRKMQ..Y
Q9I932_CYPCA/1587-1697GDLSVSADSTRVFAKRKH...------------CKSD.LKE..GK.TYLIM....G-----NDG...PTKDLNGNMQ..Y
Q7SZG2_TAKRU/1574-1684GDVSVKVDSVRVFLKRGQ...------------CKAN.LDL..GK.EYLIM....G-----KDG.....STRDSRGMIQY
Q4RHV3_TETNG/135-245EDIGVMEGSIRVFAKRRQ...------------CKVQ.LDL..RK.DYLIM....G-----KDG.....STRDSRGMMLY
Q70TF5_ONCMY/1595-1705GDVKLEESKVRVLAKRLQ...------------CKGQ.LET..GK.TYLIM....G-----KDG...STTDSNGQMQ..Y
Q9IBG9_ORYLA/1588-1699DLLVKKENSVRVFAKRLQ...------------CKGQ.LEV..GN.QYLIM....G-----KDG...STTDTDGKMQ..Y
Q076D6_CHICK/1536-1646QDTAVAPGERRRLLVRKS...------------CP...LRLQLHN.IYLVM....G-----GSG...RTRDPEGRPQ..F
CO4A_HUMAN/1615-1725KDVKAAANQMRNFLVRAS...------------CR...LRLEPGK.EYLIM....G-----LDG...ATYDLEGHPQ..Y
Q62238_MOUSE/465-575TDTMASIGQTRNFLSRTS...------------CR.LRLEP..NK.EYLIM....G-----MDG...ETSDNKGDPQ..Y
Q969A4_BRABE/1602-1713.LDDVFDGEERVFWKRKT...------------CSGLQLVE..GT.TYLLM....G-----KDGTKYTDEQGFDSFR..Y
Q8AYN9_CYPCA/1560-1672QTDDLKTDSEIDLVKKAT...------------CSSTNFEV..GK.QYLIM....T-----AES...IKIRMNRGYKYKF
Q4SXM5_TETNG/1606-1718ELEAVSSGTPVELVKRAT...------------CTSVEIQE..NQ.QYLLM....G-----SGG...SEIRLERSFRYRL
Q6VPV1_PIG/1548-1659.EAVAEKGSEITFIKKTT...------------CTNANLEK..GK.QYLIM....G-----KEA...LQIKHNFNFKYIY
Q99KX9_MOUSE/254-364..EAADENSEVTFIKKMS...------------CTNANLVK..GK.QYLIM....G-----KEV...LQIKHNFSFKYIY
CO5_HUMAN/1550-1661.EAVAEKDSEITFIKKVT...------------CTNAELVK..GR.QYLIM....G-----KEA...LQIKYNFSFRYIY
Q4SVH8_TETNG/1716-1828VEPGVQPGHRRFFMAHGG...------------CRDG.LELKLGS.QYLIM....G-----PKEDRWSIDSSTNQFL..Y
A5PMP6_DANRE/1549-1662TEEGLNEKERRMFLSHAS...------------CRTR.LNLKEGQ.EYLVI....G-----PITDVWNAGSTVSN.KYVY
Q9W6G1_PROAT/775-885.SDDAQKGSQKIFITHSN...------------CREI.LSLKIDK.QYLVK....G-----HIT.....DLWNLQKEMAY
Q91588_9PIPI/1460-1570.TDEDPEDKTRNFISHIK...------------CRKA.LNMQLNR.DYLIW....G-----VTG.....DLWRQPDGYSY
VCO32_AUSSU/1522-1632.TDRNPQAKARQYVSQRK...------------CQEA.LNLNLNN.DYLIW....G-----LSS.....DLWPMKNDISY
VCO3_NAJKA/1513-1623.TDENPRAKTHQYISQRK...------------CQEA.LNLKVND.DYLIW....G-----SRS.....DLLPTKDKISY
Q90633_CHICK/1523-1633.TDENPGGSNRTFVSHKQ...------------CRDA.LSLQKGQ.DYLVW....G-----LAS.....DLWVTGSRFSY
Q3L2T4_MACEU/1523-1632.SDENAQGKIQTFISHVK...------------CRDA.LLLKEGK.DYLIW....G-----ISS......DLWKMKELNY
CO3_RABIT/597-707.SDEVQAGQPAPFISHIK...------------CRDA.LKLKDGK.HYLMW....G-----LSS.....DPVGEKPNTSY
CO3_BOVIN/1532-1642.SDEVQVKQERKFISHIK...------------CREA.LKLKEGA.HYLVW....G-----VSS.....DLWGEKPKISY
A6MK21_CALJA/94-204.TDEVQVGQQRTFISPIK...------------CREA.LKLEKGK.LYLMW....G-----LSS.....DFWGEKPNISY
CO3_RAT/1534-1644.SDEVQAGQERRFISHVK...------------CRNA.LKLQKGK.QYLMW....G-----LSSDLW.....GEKPNTSY
Q9DDV9_ONCMY/1553-1662.TDLVLEGGKRLFLAHPS...------------CREA.LDLKEGQ.SYLLI....G-----DTA......DLIQSVTDRY
Q98977_ONCMY/1484-1594.TDLLLNGEKRLFLAHPS...------------CRKA.LDLEEGQ.SYLLM....G-----DTA...ALIQSGDRFE..Y
Q3L5A8_GADMO/75-188.SDKEPSGKLRTFIGYSH...------------CRET.LNLKTNA.SYLIM....G-----TVK....NAQKVGRNQYEY
Q98TS6_ANAMI/1526-1643SKDVGPLNKERTLLSYPH...------------CRDP.LDLRTGN.NYLIM....G-----AST...DIYRDDQAQSHQY
Q4S019_TETNG/1311-1428NNDVAPKGKQRIFLGYPH...------------CRAA.LDLKKDK.NYLIM....G-----ASR.DIHMDREEKMYQ..Y
Q9IBH1_ORYLA/1522-1639STDVGPRGKLRPFLSYPH...------------CRDA.LNLQKGK.TYLIM....G-----SSR...DIHKDEKQLTYQY
Q4RJA3_TETNG/792-902SYDVGPQGKQRVFLGFPN...------------CRKS.IGLVKGK.TYLIM....G-----LST...DIYKDEKNQMYQY
Q4RZT6_TETNG/1515-1632NTDVAPQGKQRPFLSYPH...------------CRES.LNLTKGK.TYLLM....G-----SSK...DIHGGEKGEAFQY
CO3_ONCMY/1507-1621.TDEGVEGKNRDFMGLAY...------------CREA.LGLMQGK.TYMIM....G-----KSE.DLHRVEDKGLLQYKY
Q3MU73_DANRE/1522-1632.TDPDVEGKVKPFLARPS...------------CRVS.LGLVEGK.SYLIM....G-----NSV...DLPTLGGSLQ..Y
Q9YIA6_CYPCA/1030-1140.TDVNVEGKVRPFFARPS...------------CREY.LGLLEGK.SYLIM....G-----KSV...DLPELRGSLQ..Y
Q6UAQ6_CTEID/1510-1620.TDEDVEGRVRLFLARPS...------------CRED.LGLVKGK.SYLIM....G-----KST...DLPKLGGSLQ..Y
Q9YIA9_CYPCA/1513-1623.TDVDVEGKRRPFLARPT...------------CRNH.LGLVEGK.SYLIM....G-----RSV...DLPDLGGSLQ..Y
Q4S5G7_TETNG/453-556GLRFFGKEPLEVTLLNMDWN.------------CPCPNITT..ANEQLVVM....G-----DVH............NGMA
O44344_STRPU/1565-1680DEDVPHQAQRQLFINEG....------------CDCPKVKGRNIGGTFLLV....G-----QKSLKYTTEQGEERYR..Y
A7SX91_NEMVE/256-359...LSEPAEMLIRVPGGK...------------CPCPPLRV..GE.NYVLM....G-----SMR.......TTSKGKTRM
Q4RGB2_TETNG/197-294GLKKKELKSLVLYLKNGAD..------------CPCQQLDQ.LGH.HYLVM....G-----RRV................
A3KNP6_DANRE/185-282SMKKQDLKKLVLYLKSGAH..------------CPCQQLEN.LEN.HYLIM....G-----RSV................
Q32PN6_DANRE/181-278TLKKKDLKKLTLYLKNGAD..------------CPCTQLDN.TRN.TYLIM....G-----RKV................
Q6GZK1_ORYLA/191-288NLKKRDLKKLTLYLKNGAN..------------CPCQQLEN.LEN.QYLIM....G-----RKV................
Q3KQ69_XENLA/197-293PIQKKDWAELVLYLKNGAN..------------CPCHQLDQLKG..QFLVL....G-----RKA................
SFRP5_HUMAN/195-293PLKRKDTKRLVLHMKNGAG..------------CPCPQLDSLAG..SFLVM....G-----RKV................
Q4SKX3_TETNG/205-303ALRKKDLKKLTLYIKNGAN..------------CPCSQLDS.LGS.NFLIM....G-----RKV................
SFRP1_MOUSE/200-296PIKKKELKRLVLFLKNGAD..------------CPCHQLDN.LSH.NFLIM....G-----RKV................
SFRP1_CHICK/200-296PIRKKNLKKLVLLLKNGAD..------------CPCHQLDN.LGH.HFLIM....G-----RQV................
A4IGU5_XENTR/180-278GWSDEELRKTVLWLSDGDN..------------CLCQDIHE.PGA.TVLVL....G-----HRA................
L8I1X6_9CETA/186-284GVSEKDLKKSVLWLKDSLQ..------------CTCEEMND.INA.PYLVM....G-----QKL................
Q7ZXM6_XENLA/190-288GVTERDLKKTVLWLKDGLQ..------------CTCDEMND.INA.PYLVM....G-----QKL................
Q32SK8_DANRE/445-554TRLRLSRGSRTLYPESWMSRG------------CTCPVLFP..GGLEYLVV....G-----HED........VRKGR..P
Q0VEM1_MOUSE/517-624.KLKILRGKRTLYPESWTNRG------------CTCPILNP..GL.EYLVA....G-----HED........VRTGK..L
Q4RSD5_TETNG/491-599AGMKIRRGSATLYPESWTEQG------------CTCPILNP..GS.EYVVA....G-----HQD........WKTGR..P
Q4S5B2_TETNG/454-562TKVKIQRGRATLYPESWTARG------------CTCPILNP..GG.EYLVA....G-----HSD........RKQGR..L
Q2HJB6_BOVIN/340-444.GLDLPSPPTDTLLKFYVPC.------------KQCPPMKK..GI.SYLLM....G-----QVD........KNRGP...
Q3UIP2_MOUSE/353-457.GLDLPSPPSGTSLKLYVPC.------------RQMPPMKK..GA.SYLLM....G-----QVE........ENRGP...
PCOC1_HUMAN/330-434.GLDLPSPPTGASLKFYVPC.------------KQCPPMKK..GV.SYLLM....G-----QVE........ENRGP...
Q7ZWR8_XENLA/379-484.GLSIQESGKTMSIKVINEC.------------PKCPILKK..GS.SYLFM....G-----EVN.......AEGQGR...
Q66IT1_XENLA/372-477.GLSIQGSGKTMSIKVINEC.------------PKCPILKK..GS.SYLFM....G-----EVN.......AEGQGR...
Q1RMV2_BOVIN/310-413.NLAIQQAGKNMSAKVLVVC.------------KQCPLLRR..GL.NYIIM....G-----QVG.......EDGRGK...
PCOC2_MOUSE/308-411.NLAIQQAGKNMSVKLTVVC.------------RQCPLLRR..GL.NYIIM....G-----QVG.......EDGRGK...
Q4S4Z9_TETNG/252-355.NLAIQQAGKTMSTKIVILC.------------KKCPFVRR..GL.NYVFT....G-----QVD.......EDGRGK...
Q52L01_XENLA/302-405.TLAIQQAGKNMSAKITVVC.------------KQCPMVRR..GL.NYIIM....G-----QVD.......EDGRAK...
SFRP4_HUMAN/188-289..SPIPRTQVPLITNSS....------------CQCPHILP..HQ.DVLIM.....-----.........CYEWRSR..M
O08570_MESAU/127-229.LVNIPRDTVNLYTTSG....------------CLCPPLHV..NE.EYIIM....G-----YED........EERSR..L
Q32N13_XENLA/189-292.LVNIPKDTVTLYTNSG....------------CLCPQLVA..NE.EYIIM....G-----YED........KERTR..L
Q9W6E0_DANRE/200-303.LVNIPRDTVTLYYNSG....------------CLCPPLTA..ND.EYIIM....G-----YEN........EERSR..L
Q4S9P7_TETNG/197-299.LVNIPKETHTLYYSSS....------------CLCPPLAI..GE.EYLIM....G-----YEN........EERSR..L
X6R4H8_HUMAN/364-467...SPLRAREYVWAPGH....------------CPCPMLAP..HR.DYLMA....V-----QRL......VSPDGTQDQL
A7SBN2_NEMVE/182-284...AVRITKRQLLELRGRELT------------CNCSQVLP..SK.VYLII....G-----KED..........KHRRVL
Q9NL28_CIOIN/535-642GMRLKKKEMIDIQVRDRVLQ.------------CLCPRLRV..NR.TYLLL....G-----KYA......RSDGNLR..M
Q95YK2_CIOSA/556-663VVRFRKKERVDVEVRDRIVH.------------CLCPKLQV..KK.TYLLI....G-----KYN......RSGGEPR..L
A0A9Q8_MOLTE/181-286QNRKFVKGRQVLRARGTHIKP------------CNCTKLLLGAGK.KYLIF.....-----............SSYSKPF
A7SHI5_NEMVE/436-545RTRRVRRGDGYVWIKKRDFR.------------CRCPKLKP..GR.SYFIA....G-----NLR........GQSRKRSI
UNC6_CAEEL/491-597.TENMQRGETSLWISPQGVI.------------CKCPKLRV..GR.RYLLL....G-----KND........SDHERDGL
Q0IGC3_AEDAE/141-257ATSSQRKSSVGLLVPSKNLD.------------CRCPSIKI..NK.SYLIL....G-----MDS.........KQNPDSL
O96659_HIRME/495-600.KDRLRRGEDTVWVSTKDLN.------------CRCPRLRV..KQ.SYLVV....G-----KDS.......SSSRGG..I
Q4SF52_TETNG/899-1011SASRVRKGPHSLWVPDRDLR.------------CGCPALHV..GR.TFLLI....G-----TVE....GERAWGPEESRL
Q0V9H1_XENTR/485-591.RVPIRRGDQPLWVPDHDLA.------------CDCLRVQV..GK.SYLII....G-----NDE......ESPDPAR..L
NET5_MOUSE/314-431.AWPVRRGGQEAWVPRADLI.------------CGCLRLRP..GA.DYLLL....G-----RAA...QTHDDDNYDPARL
NET5_HUMAN/361-468.AQPVRRGDQDAWVPRADLT.------------CGCLRLQP..GT.DYLLL....G-----SAV........GDPDPTRL
Q52KG2_MOUSE/457-570.EERARRGSSALWVPTLDAA.------------CGCPRLLP..GR.RYLLLGGGPG-----AAA...GSTAGRGQ.G..L
K7CDB2_PANTR/488-594.TSRIRRGDQSLWIRSRDIA.------------CKCPKIKP..LK.KYLLL....G-----NAE......DSPDQSG..I
O42203_DANRE/487-595.GHRIRRGDQLLWVRAKDVA.------------CKCPKIKP..GR.KYLLM....G-----SDE......EEDSRGQSGV
NET3_CHICK/465-571.DERVKRGDNFLWIHLKDLS.------------CKCPKIQI..SK.KYLVM....G-----ISE......NSTDRPG..L
Q32SK9_DANRE/482-590.GDPLKRGDHMLWVHMKDLA.------------CKCPRIHM..GK.RFLIL....G-----STE....GTANPERPG..L
Q9NFW6_BRAFL/441-548QSLKLRRGDQYMYVRQSDLQ.------------CKCPKLRL..GR.KYLLM....G-----SVD......SNNNREG..L
Q59JG2_HEMPU/509-616.EQRIRRGNTFLYVRQRDLT.------------CKCPKIRL..RH.RYLIL....G-----DED.......DSSSKRDGI
Q1PHQ2_SACKO/484-590.QNKIRRGDQILYVHNRDLT.------------CKCPKLRL..GR.KYLII....G-----NDN......KNPNQNG..L

PF00965

Q29AK5_DROPS/26-197ITERHGFSGGYGKSCN.CTVSPCFGQQCLR..HREYSDGCKWSPFGKCERDYSACMPHVTHT.VNGSISRCRW
Q1RLX2_DANRE/24-203ATQKKSLSQRYQMGCD.CKITRCATFPCE....ISAPEECLWTDW.VTEKIIHGRQSDHYAC.IKRGDGSCAW
A7SSJ2_NEMVE/18-205QAQRLGVQSVYGESCR.CRVTSCS.........FLGPGGLILDSH.........CSEGYLYC..GEHGLSCAW
TIMP2_CAVPO/25-203TTQKKSLNHRYQMGCE.CKITRCPMIPCY....ISSPDECLWMDW.VTEKSINGHQAKFFAC.IKRSDGSCAW
TIMP3_BOVIN/22-194LSQRKGLNYRYHLGCN.CKIKSCYYLPCF....VTSKNECLWTDM.FSNFGYPGYQSKHYAC.IRQKGGYCSW
A7SSJ1_NEMVE/20-204VSQQIAVKRYYGRHCA.CRTSLCS.........LLDPLGTLLDFE.........CAREHLYCRLRRDGATCGW
Q9GPJ2_CRAGI/21-203PHQRRGIRYMYEQGCN.CTIHHCRGENCDFPQSLNPDQTCIWPGS....YNTNDCYAKYGFC.LPDIFGVCYW
TIMP1_MOUSE/23-199PAQQRAFSKTYSAGCGVCTVFPCLSIPCK....LESDTHCLWTDQ.VLVGSE.DYQSRHFAC.LPRNPGLCTW
TIMP4_RAT/28-207LVQRESLNHHYHQNCG.CQITTCYAVPCT....ISAPDECLWTDW.LLERKLYGYQAQHYVC.MKHVDGICSW
Q16IW9_AEDAE/30-198IVEKRGLAGIYRKGCS.CQIKPCFSGEC.....NMTIGACNWTPWASCETDYGSCIPTRGYL.IDGSPAKCHW
TIMP1_HUMAN/22-199LAQRRGFTKTYTVGCEECTVFPCLSIPCK....LQSGTHCLWTDQ.LLQGSEKGFQSRHLAC.LPREPGLCTW
F6NH88_DANRE/71-248LTQKKSLGPRYQMGCD.CKIVQCPIIPCS....ISEPVECLWTDW.VLEGTVQGTQAQHYTC.VKRSDSSCAW
H2LU60_ORYLA/26-204ATQKKNLIQRYESSCD.CKITHCTSIPCV....LSSPTECLWTDW.VIEKTVKGEQAKHYAC.IKRNDDSCAW
H2SZH2_TAKRU/30-202LAQKKGFNHRYQLGCN.CRIKPCHYLPCF....VTSKNECLWTDM.LSNLGYPGYQSRHYAC.IQQKEGYCSW
H2USP3_TAKRU/28-207LSQKKNLNYRYQIGCE.CRINTCYTVPCV....STGENECLWTDW.LLDNSLNGEQARQYAC.IRRSDTTCSW
H3C979_TETNG/26-206AAQKKGLSQRYQMGCE.CKIVRCPSLPCE....VSAPEECLWTDL.VLEKLVYGRQANHYAC.IKRADRSCSW
H3CWM8_TETNG/28-206ATQKKSLTQRYEMGCD.CKITRCTSIPCL....ISSPSECLWTDW.VMEKAVYGQQAKHFAC.IKRSDDSCAW

PF01759

Q8WPD8_CIOIN/1602-1707LLITGSLIE....RRQ-NRNRLLQT------------------------------------------------
Q8I7P1_9CNID/1611-1718VLGHNVFVKEWPMND.-.PVDFFKK------------------------------------------------
Q8MX24_ANCCA/29-132SVSRCDLLRNW.TDVS-GEEKKLLG------------------------------------------------
Q5NKN5_CARRO/1605-1719ILDQSTSIFKWTRISV-AENKQLTK------------------------------------------------
CO3_EPTBU/1496-1605VLTSDTWFEKFPLESV-CRLPSPPA------------------------------------------------
CO3_LAMJA/1543-1654VLDASSWVEQWPVDEK-CNQPNVQT------------------------------------------------
Q9I933_CYPCA/1566-1681VLNNDMWIEKMPEEKN-CKATKNRA------------------------------------------------
Q91741_XENLA/1554-1664ILEKNFWVEELPGEQK-CAATRYRN------------------------------------------------
Q76KI4_TRISC/1564-1675LLDVKSWVEAIPPEDI-CELRKYRS------------------------------------------------
Q9I932_CYPCA/1587-1697LLDSKTWVEEKLSPST-CRASVNKG------------------------------------------------
Q7SZG2_TAKRU/1574-1684LLESNTWVERKPLPIN-CGKSAHRP------------------------------------------------
Q4RHV3_TETNG/135-245LLESNTWVEMKPPQDS-CKKSANRN------------------------------------------------
Q70TF5_ONCMY/1595-1705LLESKTWIEQVPNEKK-CQGSKNRP------------------------------------------------
Q9IBG9_ORYLA/1588-1699LLESDTWVEKMPSAED-CKKSFNKN------------------------------------------------
Q076D6_CHICK/1536-1646LLGPHSWLEEVPSPGR-CKATRLRG------------------------------------------------
CO4A_HUMAN/1615-1725LLDSNSWIEEMPSERL-CRSTRQRA------------------------------------------------
Q62238_MOUSE/465-575LLDSNTWIEEMPSEQM-CKSTRHRA------------------------------------------------
Q969A4_BRABE/1602-1713VITEQSFVAEWPTGAK-AERKKFKR------------------------------------------------
Q8AYN9_CYPCA/1560-1672PLDSRAWVDWWPLDTD-CRDDACIQ------------------------------------------------
Q4SXM5_TETNG/1606-1718PLDSEALLELWPT..D-CGSPECLD------------------------------------------------
Q6VPV1_PIG/1548-1659PLDSSTWIEYWPTDTA-CPSCQTFL------------------------------------------------
Q99KX9_MOUSE/254-364PLDSSTWIEYWPTDTT-CPSCQAFV------------------------------------------------
CO5_HUMAN/1550-1661PLDSLTWIEYWPRDTT-CSSCQAFL------------------------------------------------
Q4SVH8_TETNG/1716-1828MLGKDTWVERWPTPAE-CSSTGSLP------------------------------------------------
A5PMP6_DANRE/1549-1662TLGKETWVERWPDESE-CGSTLQKK------------------------------------------------
Q9W6G1_PROAT/775-885VIGKNTLLEWWPNDVE-CQDIQYQK------------------------------------------------
Q91588_9PIPI/1460-1570IIGKDTWMEWWPNERE-CQQRENQD------------------------------------------------
VCO32_AUSSU/1522-1632LITKNTWIERWPNEDE-CQDEEFQN------------------------------------------------
VCO3_NAJKA/1513-1623IITKNTWIERWPHEDE-CQEEEFQK------------------------------------------------
Q90633_CHICK/1523-1633LISKDTWLEAWPLEES-CQDADLQP------------------------------------------------
Q3L2T4_MACEU/1523-1632IIGKDTWVELWPQEDE-CQDEEYQK------------------------------------------------
CO3_RABIT/597-707IIGKDTWVEFWPEKEE-CQDEENQK------------------------------------------------
CO3_BOVIN/1532-1642IIGKDTWVELWPEAEE-CQDEENQK------------------------------------------------
A6MK21_CALJA/94-204IIGKDTWVEHWPEEDE-CQDEENQK------------------------------------------------
CO3_RAT/1534-1644IIGKDTWVEHWPEAEE-RQDQKNQK------------------------------------------------
Q9DDV9_ONCMY/1553-1662VLGERTWIEYWPTSDE-CNMQDQEK------------------------------------------------
Q98977_ONCMY/1484-1594VLGERTWIESWPTSDE-CSIQGPTR------------------------------------------------
Q3L5A8_GADMO/75-188LLGEQSWIEYWPTPLE-CQNPKYGS------------------------------------------------
Q98TS6_ANAMI/1526-1643VLGERTWIEYWPTDKQ-CQTEEYRR------------------------------------------------
Q4S019_TETNG/1311-1428ALGEKTWVEYWPTEAE-CKTVQHRP------------------------------------------------
Q9IBH1_ORYLA/1522-1639VLGERTWIEYWPTAEE-CQGDEHRA------------------------------------------------
Q4RJA3_TETNG/792-902VLGERTWIEYWPTVAE-CQTDEYRP------------------------------------------------
Q4RZT6_TETNG/1515-1632VLGERTWVEYWPTQEE-CQTEEHTE------------------------------------------------
CO3_ONCMY/1507-1621VLGEQTWIEYWPSQQE-CTSRDYRE------------------------------------------------
Q3MU73_DANRE/1522-1632IIGEQTWIEYWPTSDE-SKSAEHRD------------------------------------------------
Q9YIA6_CYPCA/1030-1140VFGEQTWVEYWPTREE-SQTREHRE------------------------------------------------
Q6UAQ6_CTEID/1510-1620ILGEKNWVEYWPTREE-SQMKKYRD------------------------------------------------
Q9YIA9_CYPCA/1513-1623IFGEQTWIEYWPTRKE-SQTQEHRD------------------------------------------------
Q4S5G7_TETNG/453-556VLQPDSFVTL...SSA-RKIRKLRE------------------------------------------------
O44344_STRPU/1565-1680VYGPTSKLEFWPATRK-ARNAAVFD------------------------------------------------
A7SX91_NEMVE/256-359RLTPKNFVREWSLEFN-SKVEDYKR------------------------------------------------
Q4RGB2_TETNG/197-294...EQHFLLTGIHKWD-KSSKEFRK------------------------------------------------
A3KNP6_DANRE/185-282...GKQYVLTGIHKWD-NSSKDFKK------------------------------------------------
Q32PN6_DANRE/181-278...DKQYLLTGIHKWD-KSNREFKK------------------------------------------------
Q6GZK1_ORYLA/191-288...DKQFLLTGIHKWD-KSSKEFKK------------------------------------------------
Q3KQ69_XENLA/197-293...KAQHLLTAIHKWD-KTNREFNR------------------------------------------------
SFRP5_HUMAN/195-293...DGQLLLMAVYRWD-KKNKEMKF------------------------------------------------
Q4SKX3_TETNG/205-303...DQQLLLMSIHKWD-KKSKELKF------------------------------------------------
SFRP1_MOUSE/200-296...KSQYLLTAIHKWD-KKNKEFKN------------------------------------------------
SFRP1_CHICK/200-296...KTQHLLTAIYKWD-KKNKEFKK------------------------------------------------
A4IGU5_XENTR/180-278...DDRLVISWVRKWQ-KSEKETKR------------------------------------------------
L8I1X6_9CETA/186-284...GGELVITSVKRWQ-KGQREFKR------------------------------------------------
Q7ZXM6_XENLA/190-288...GGELVITSVKRWQ-KGQQKFKR------------------------------------------------
Q32SK8_DANRE/445-554VVNMKSIVKPWRASLS-RKVHQLLK------------------------------------------------
Q0VEM1_MOUSE/517-624IVNMKSFVQHWKPALG-RRVMHILK------------------------------------------------
Q4RSD5_TETNG/491-599VVNTKSLVKPWRSSLG-RKFLHILR------------------------------------------------
Q4S5B2_TETNG/454-562LVNMKSFVKPWKASLG-RKVLTLLK------------------------------------------------
Q2HJB6_BOVIN/340-444ILPPESFVVLHRPTQH-QILTNLSR------------------------------------------------
Q3UIP2_MOUSE/353-457ILPPESFVVLYRSNQD-QILNNLSK------------------------------------------------
PCOC1_HUMAN/330-434VLPPESFVVLHRPNQD-QILTNLSK------------------------------------------------
Q7ZWR8_XENLA/379-484.IVPESFVIAHKAAQH-QILTAISK------------------------------------------------
Q66IT1_XENLA/372-477.IVPESFVIGYKVAQH-QFLTAISK------------------------------------------------
Q1RMV2_BOVIN/310-413.IMPNSFIMMFKTKNQ-KLLDALKN------------------------------------------------
PCOC2_MOUSE/308-411.IMPNSFVKMFKNKNQ-KPMNALKN------------------------------------------------
Q4S4Z9_TETNG/252-355.IAPHHFVMAFKTKNQ-KGLNVLKN------------------------------------------------
Q52L01_XENLA/302-405.VLPSNYVMTFKTKNQ-KILNTLKN------------------------------------------------
SFRP4_HUMAN/188-289MLLENCLVEKWRDQLS-KRSIQWEE------------------------------------------------
O08570_MESAU/127-229LLVEGTIVEKWKDRXG-XKVKRWDM------------------------------------------------
Q32N13_XENLA/189-292LLVEGSLAEKWRDRLA-KKVKRWDQ------------------------------------------------
Q9W6E0_DANRE/200-303LLIDRSIAQKWKEKIG-RKVKRWDQ------------------------------------------------
Q4S9P7_TETNG/197-299LLIDGSIAQKWKDKMT-RKIKRWDQ------------------------------------------------
X6R4H8_HUMAN/364-467LLPHAGYARPWSPAED-SRIRLTAR------------------------------------------------
A7SBN2_NEMVE/182-284FVDGMVSALEW.DVDG-KKMARMIR------------------------------------------------
Q9NL28_CIOIN/535-642TIDKNSVIISWLNKYK-KMLRRVAK------------------------------------------------
Q95YK2_CIOSA/556-663AIDKGTIVMEWKNKYK-RRLRSLQR------------------------------------------------
A0A9Q8_MOLTE/181-286ILDPSDSVLPWRDGYQ-NKLNRYTK------------------------------------------------
A7SHI5_NEMVE/436-545VLNGRSVVLPWNEKLL-KRIYRFIK------------------------------------------------
UNC6_CAEEL/491-597MVNPQTVLVEWEDDIM-DKVLRFSK------------------------------------------------
Q0IGC3_AEDAE/141-257VLGPKTIIIEWKDDWN-RRLRRFQQ------------------------------------------------
O96659_HIRME/495-600ILDQTSLVVPWSEQQA-LRIKQITK------------------------------------------------
Q4SF52_TETNG/899-1011VADRSTLALQWREHWG-HKLRGFRG------------------------------------------------
Q0V9H1_XENTR/485-591ILDKNSLALPWRDVWG-HKLRRFQQ------------------------------------------------
NET5_MOUSE/314-431ILNRHGLALPWRPRWA-RPLRRLQQ------------------------------------------------
NET5_HUMAN/361-468ILDRHGLALPWRPRWA-RPLKRLQQ------------------------------------------------
Q52KG2_MOUSE/457-570SAARGSLVLPWRDAWT-RRLRRLQR------------------------------------------------
K7CDB2_PANTR/488-594VADKSSLVIQWRDTWA-RRLRKFQQ------------------------------------------------
O42203_DANRE/487-595VADRGSLLIPWKDLWA-RRLRKFQQ------------------------------------------------
NET3_CHICK/465-571MADKNSLVIQWRDAWT-RRLRKLQR------------------------------------------------
Q32SK9_DANRE/482-590QADKNSLVIQWRDIWT-RRLRKFQR------------------------------------------------
Q9NFW6_BRAFL/441-548TLDYRSTSIPWRNRWG-KRLRRLQR------------------------------------------------
Q59JG2_HEMPU/509-616VVDNKSIVLKWRDEWD-MRMRKFQR------------------------------------------------
Q1PHQ2_SACKO/484-590LADHKSYVIPWRDDWN-RRMRKFQR------------------------------------------------

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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