Sequence alignment for CL0353

PF00965

Q29AK5_DROPS/26-197DACSCM.P.SHPQTHFCK------ADY..VVQLRV....LRKSDTIDPG............KTTYKVHIKRTYKAT----
Q1RLX2_DANRE/24-203EACSCS.P.VHPQQAFCN------ADV..VIRAKV....VGKKEVDSGNDIYGNP....IKRIQYEIKQIKMFKGP----
A7SSJ2_NEMVE/18-205KACVCKMG.SHPQDKFCQ------ADF..VVRGRVESGPVEGYITYPPQSRGFRHWPKQRDVLVHVVMVTQIFKGA----
TIMP2_CAVPO/25-203DACSCS.P.VHPQQAFCN------ADV..VIRAKA....VSEKEVDSGNDIYGNP....IKRIQYEIKQIKMFKGP----
TIMP3_BOVIN/22-194EACTCS.P.SHPQDAFCN------SDI..VIRAKV....VGKKLLKEGPF..........GTMVYTIKQMKMYRGF----
A7SSJ1_NEMVE/20-204DDCICASPHGHPQDVFCS------SDY..ALRGLV....TSGPKKETIKIMQPPDKPLTRNVLSYIVEIREVYRGG----
Q9GPJ2_CRAGI/21-203HSCMCD.F.THPQNNFCS------ADF..VIKATI....VKEELKFGDESMGIPFP..LQKNYTVQFKKRDIFKGS----
TIMP1_MOUSE/23-199KACSCA.P.PHPQTAFCN------SDL..VIRAKF....MGSPEINETT...........LYQRYKIKMTKMLKGF----
TIMP4_RAT/28-207EACSCA.P.AHPQQHVCH------SAL..VIRAKI....SSEKVVPASEDPADTQ.....KMIRYEIKQIKMFKGF----
Q16IW9_AEDAE/30-198EACSCL.P.EHAQTAYCD------AEY..VIVAQV....LRKSNRKHND............NNVYKIAIKKEYKMS----
TIMP1_HUMAN/22-199RACTCV.P.PHPQTAFCN------SDL..VIRAKF....VGTPEVNQTT...........LYQRYEIKMTKMYKGF----
F6NH88_DANRE/71-248.ACSCS.P.EHPQQAYCN------ADV..VIRAKV....VGRKEVVTGNDAYGYP....IKMIRYDVKQLKMFKGP----
H2LU60_ORYLA/26-204EACSCS.P.AHPQQAVCN------SDV..VIRAKL....VGRQEVDAGNDIYGNT....IKRIKYDVKQIKMFKGP----
H2SZH2_TAKRU/30-202EGCSCA.L.THPQDAFCN------SDI..VIRAKV....VGKKLLRDGP.....F.....GTMRYTVKQMKMYKGF----
H2USP3_TAKRU/28-207EGCSCL.P.AHPQQLFCS------SEI..VIRAKI....SGEKIVSPSNNSSPYM.....KMIQYEIKMIKMFKGF----
H3C979_TETNG/26-206EACSCA.P.VHPQQAFCN------ADVGRVIRAKV....VGEQEVNSGNDIYGNP....IKRIQYEVKQVKMFKGP----
H3CWM8_TETNG/28-206EACSCS.P.AHPQQAFCN------ADV..VIRAKL....VERQEVDVGNDIYGNP....VKQIKFGVKQIKMFKGP----

PF01759

Q8WPD8_CIOIN/1602-1707-------------DEGCS......AKY--VYKVRV........IGVREDS.---------VFVNLDAVIEDVYRSG....
Q8I7P1_9CNID/1611-1718-------------GLFCT.....TYDY--AFKGKL........LIIDEED.---------QWLHLTFEVVEVYKES....
Q8MX24_ANCCA/29-132-------------KLLCQ......SQF--VTHAKV........TKKRIDG.---------YFIYYDLEHKEVYKPK....
Q5NKN5_CARRO/1605-1719-------------DRACV.....DHDY--VWKGTV........ESKRKEN.---------GFRYISFRVTSVFKEG..IE
CO3_EPTBU/1496-1605-------------GNACR......AEY--VFIIGV........TKVTKTA.---------SYININAALKTVLKKG....
CO3_LETCA/1543-1654-------------EAACV....AGIDY--AYVGIV........DNRTEVG.---------SFVYYTVNIQTVIKSG....
Q9I933_CYPCA/1566-1681-------------RYACY...SPGVDY--AYVIKV........LNSSTDH.---------VFMYYTTLITDVLQTG...L
Q91741_XENLA/1554-1664-------------TFACY...SPRVVF--GYRVMV........ENIAEQD.---------AFIVYTARILEVLQRN....
Q76KI4_TRISC/1564-1675-------------DFACY...SPIVDY--AYTVRV........LNISSAG.---------SFDNYQVSIADRLKMS...N
Q9I932_CYPCA/1587-1697-------------EYACF...HTNIEY--AFEVIV........NSVTEES.---------NFMLYSATVTVVLRYT....
Q7SZG2_TAKRU/1574-1684-------------QHACF...IPTVDY--AYIVEV........FNISMKS.---------NFEVYETRLKDVLRTH....
Q4RHV3_TETNG/135-245-------------QHACF...VPTVDY--AYVVEV........LNVSMKS.---------NFELYEARVKDVLRNH....
Q70TF5_ONCMY/1595-1705-------------EHACY...SPTVDY--GFIVQV........ISMSVKS.---------NFELYTTNVTQVLRAT....
Q9IBG9_ORYLA/1588-1699-------------EHACF...YPVVDY--AYIVTV........NSVSLKS.---------NFELYKANIANVLKSS...G
Q076D6_CHICK/1536-1646-------------DFACY...SPRVDY--ALVVRV........LSQSEIG.---------AFVAFETEIKEVLLEG....
CO4A_HUMAN/1615-1725-------------KFACY...YPRVEY--GFQVKV........LREDSRA.---------AFRLFETKITQVLHFT....
Q62238_MOUSE/465-575-------------RFACY...YPRVEY--GFTVKV........LREDGRA.---------AFRLFESKITQVLHFR....
Q969A4_BRABE/1602-1713-------------EKACN.....DLDY--AFRVIV........MEVRQEG.---------SFDRISMIVESPIKKG....
Q8AYN9_CYPCA/1560-1672-------------NDMCK....ESMNY--AFKVLI........ESSEAGG.---------DFVTYKAKVKAVLMKG....
Q4SXM5_TETNG/1606-1718-------------SETCR....PQIRY--AYKVMV........KSSAAEG.---------DFMTYAATVVEVLKNS..DK
Q6VPV1_PIG/1548-1659-------------ETACK....PEIAY--VYKVKI........IAMTEES.---------AFVKYTASLLDVYKAG....
Q99KX9_MOUSE/254-364-------------EKACK....PETAY--AYKVRI........TSATEEN.---------VFVKYTATLLVTYKTG....
CO5_HUMAN/1550-1661-------------QTACK....PEIAY--AYKVSI........TSITVEN.---------VFVKYKATLLDIYKTG....
Q4SVH8_TETNG/1716-1828-------------TFACS.....SLHH--VFKVKV........ANVSQS..---------YYDSYEMEILQVIKLG....
A5PMP6_DANRE/1549-1662-------------AAVCN.....GLHH--AYRVKL........ISISQSH.---------.YYQYEMEIVQVIKEG....
Q9W6G1_PROAT/775-885-------------NEACD....PGRDY--VYKVKF........LAVNISA.---------SYDHYTAEILEVIKAG....
Q91588_9PIPI/1460-1570-------------NMGCA....PGVDF--VYKATL........TEVQPSD.---------NFDNYVMTIKKVIKQG....
VCO32_AUSSU/1522-1632-------------QKACA....PNVDY--VYKAKL........LRIEEKD.---------GNDIYVMDVLEVIKGG....
VCO3_NAJKA/1513-1623-------------EKACE....TNVDY--VYKTKL........LRIEEQD.---------GNDIYVMDVLEVIKQG....
Q90633_CHICK/1523-1633-------------DLACK....PGVDY--VYKVKV........VATEETP.---------SHDNYIMSILTVIKMG....
Q3L2T4_MACEU/1523-1632-------------EEACE....PGVDY--VYKVKV........DKIKQSD.---------SYDEYQMLIKQVIKSG....
CO3_RABIT/597-707-------------DKACE....PGLDY--VYKTKL........VQVERAD.---------DFDEYLMVVENTIKSG....
CO3_BOVIN/1532-1642-------------DKACE....PGVDY--VYKTRL........IQKKLED.---------DFDEYIMVIENIIKSG....
A6MK21_CALJA/94-204-------------DKACE....PGVDY--VYKTRL........VKIQLSN.---------DFDEYVMAIEQIIKSG....
CO3_RAT/1534-1644-------------DKACE....PGVDY--VYKTKL........TTIELSD.---------DFDEYIMTIEQVIKSG....
Q9DDV9_ONCMY/1553-1662-------------DKACE....SHMDY--VFKASM........VNATLES.---------YTDTYLMEIKMIIKEG....
Q98977_ONCMY/1484-1594-------------DKACE....AGMDY--VFKASL........VNATLES.---------YTDTYLMEIKRIIKEG....
Q3L5A8_GADMO/75-188-------------DKACD..AEVKIDY--VYKVTM........ESYVDHN.---------STDVYMMRINQVIKEG....
Q98TS6_ANAMI/1526-1643-------------AKVCETELNNKIDF--AYRVGL........EEFTDGL.---------STDIYKVRVLQVIKEG....
Q4S019_TETNG/1311-1428-------------AKACETQQFNKIDY--VYKVRV........QDFAEGL.---------STDIYTVQVLDVIKEG....
Q9IBH1_ORYLA/1522-1639-------------SKICESTESSKIEY--AYKVLV........EDVVQKP.---------SIDIYAMRVQDSIKEG....
Q4RJA3_TETNG/792-902-------------SNAKT.......DF--VYKVQV........DDFYEDL.---------STDVYTMSILESIKEG....
Q4RZT6_TETNG/1515-1632-------------AKSCETTPTSKIDF--VYKVRV........ERFTADL.---------STDVYSMRILEVIKEG....
CO3_ONCMY/1507-1621-------------DKACG....AGLDY--VYKATV........VDSKLTT.---------HTDTYTVKIDLVIKPG....
Q3MU73_DANRE/1522-1632-------------IKACE....PHLDY--IYKAKL........VKMDLKQ.---------DSDIYHMKVEKTVKEG....
Q9YIA6_CYPCA/1030-1140-------------NKACE....GGMDY--VYKATV........VGMNQTM.---------HSDIYDMKVEKVVKEG....
Q6UAQ6_CTEID/1510-1620-------------VKACE....AGMDY--VYKVTV........VGMDLAH.---------DSDIYHLKVDQVLKEG....
Q9YIA9_CYPCA/1513-1623-------------NRACE....AGMDY--VYKVKV........VGMDLKQ.---------DADIYDLEVEQVLKEG....
Q4S5G7_TETNG/453-556-------------NSFCK.....S.DF--VILGRV........TELTEEQ.---------ESGHALVTVEEILKDE..KM
O44344_STRPU/1565-1680-------------GTACA....SHSSY--ALKIRI........DEVEIKE.---------GFRICKFTVLNPIKTG....
A7SX91_NEMVE/256-359-------------AHFCI......SQH--VILARI........TKIRSNK.---------QRTVYYADVLAAYKGR....
Q4RGB2_TETNG/197-294-------------EHMCA......SEF--AFKTKI........KEVKRENR---------DRKVILHRRKKTLKAG....
A3KNP6_DANRE/185-282-------------DQMCA......SEF--AIKTKI........KEVKIDNL---------DRKVILQKRRKLVRAG....
Q32PN6_DANRE/181-278-------------DHMCA......SEF--AIKTKI........QEVKRENM---------DRKVTLQKKKRTIKMG....
Q6GZK1_ORYLA/191-288-------------ENICA......SEF--ALKAKI........KEVKQENM---------DRKVILQRRKRMVKQG....
Q3KQ69_XENLA/197-293-------------EHMCA......SDF--ALKVSI........REVKKEN.---------GDRKLLLRKKKALKKG....
SFRP5_HUMAN/195-293-------------EQMCS......SDF--VVKMRIKE......IKIENGD.---------RKLIGAQKKKKLLKPG....
Q4SKX3_TETNG/205-303-------------EHYCA......SDF--ALKMKIKE......VKKEKGD.---------RKLIAAQKKKKVLKLG....
SFRP1_MOUSE/200-296-------------EHLCA......SEF--ALRMKI........KEVKKEN.---------GDKKIVPKKKKPLKLG....
SFRP1_CHICK/200-296-------------EHLCA......SEF--ALKMTI........KEVKKEN.---------GDKVIIPRKRKALKLG....
A4IGU5_XENTR/180-278-------------QNYCS......SDF--ALKINIRS......VSTLEGD.---------VMVVPEARSRTVYKSK....
L8I1X6_9CETA/186-284-------------ETLCK......NDF--ALKIKV.KE.....ITYINRD.---------TKIILETKSKTIYKLN....
Q7ZXM6_XENLA/190-288-------------ENLCK......NDF--ALKIKV.KE.....IAYINGD.---------TKIIPETKGKTIYKLN....
Q32SK8_DANRE/445-554-------------KVFCN....AKYAY--AVKVRV........LGAHDKG.---------SHAEVDVKILKVLWDN....
Q0VEM1_MOUSE/517-624-------------KAFCG....MKYSY--VLKIKI........LSAHDKG.---------SHAEVNVKIKKVLKST....
Q4RSD5_TETNG/491-599-------------KLFCA....AEYDY--VLVVKV........MSAHDKG.---------SHAEVEVKVKKVLHQN....
Q4S5B2_TETNG/454-562-------------KLFCT....MNYAY--VLKVKV........LSAHDKG.---------SHAEVEVKVQKVLSQN....
Q2HJB6_BOVIN/340-444-------------SHFCN......SDL--VVTGMI........KSMVRGPG---------EGLTATVNVTGVYKTG....
Q3UIP2_MOUSE/353-457-------------SNFCS......SSL--VVTGTV........KTMVRGPG---------EGLTVTVSLLGVYKTG....
PCOC1_HUMAN/330-434-------------SNFCA......SSL--VVTATV........KSMVREPG---------EGLAVTVSLIGAYKTG....
Q7ZWR8_XENLA/379-484-------------SHYCA......NQF--VVTGTVNS......LTQGDSE.---------KSLLATVTIIKTFKVE....
Q66IT1_XENLA/372-477-------------SHYCA......NQF--VVTGTVNA......LTQGDSE.---------KSLLATVTIIKTYKVE....
Q1RMV2_BOVIN/310-413-------------SNYCS......SNF--VLAGTV........ITTIPRG.---------GSLHATVSIINIYKEG....
PCOC2_MOUSE/308-411-------------SNYCS......SNF--VLAGTV........ITTVTRG.---------GSLHATVSIISIYREG....
Q4S4Z9_TETNG/252-355-------------SNYCS......SNF--VITGTV........ITAVMRG.---------GSMYATVSIINVYKEG....
Q52L01_XENLA/302-405-------------SNYCS......SNF--VITGTI........ITTVSRG.---------GSVYATVSIINVYKEG....
SFRP4_HUMAN/188-289-------------ATYLS....KNYSY--VIHAKI........KAVQRSGC---------NEVTTVVDVKEIFKSS....
O08570_MESAU/127-229-------------TXFRN.....NYNY--VIRAKV........KEVKAKC.---------HDVTAVVEVKEILKAS....
Q32N13_XENLA/189-292-------------KTYLK....NNYNY--VIRAKV........KEVKVKC.---------HDATAIVEVKEILKSS....
Q9W6E0_DANRE/200-303-------------KTYSK....NNYNY--VIRARV........KEIRIRN.---------HDLSAIVEVKEVLKSS....
Q4S9P7_TETNG/197-299-------------.TYVK....NNYNY--VIRARV........KEVRNRG.---------LEPTAVVDVKEVLKSS....
X6R4H8_HUMAN/364-467-------------LHYCG......SDF--VFQARV........LGHHHQA.---------QETRYEVRIQLVYKNR....
A7SBN2_NEMVE/182-284-------------RRFCL......SDY--AIRARV........DSEVHKN.---------GHQQLRVRVSTRYKSG....
Q9NL28_CIOIN/535-642-------------AKYCK......MEY--AVMVRV........TGKIRIG.---------RRTSITYQVLRVFKRG....
Q95YK2_CIOSA/556-663-------------GKFCR......MGY--AVVVQV........TGKLTLR.---------RKTRFTLQLHKTYKRG....
A0A9Q8_MOLTE/181-286-------------KRFCR......KSI--VYEALV........ISVAEEG.---------EWIKYTIDVTKIRKKK....
A7SHI5_NEMVE/436-545-------------KRFCR......KDF--ALKVTVVR......VEKKLPN.---------SWVRATVNINTLFKRS....
UNC6_CAEEL/491-597-------------KKFCK......RDH--AVQMVV........VSREMVD.---------GWAKYKIVVESVFKRG....
Q0IGC3_AEDAE/141-257-------------NKFCK.....R.DY--AIMAKV.TGRTTSSNKHVPRD.---------.EVRFNLQVQTVFKSTNPLL
O96659_HIRME/495-600-------------VKYCK......RDY--AIHAQV........TSREIIG.---------EWAKFSVQVFSVFKKS....
Q4SF52_TETNG/899-1011-------------LFYLK.....NVSS--VLKVQV........RGMERSG.---------PWWQFSIAVQTVFREG....
Q0V9H1_XENTR/485-591-------------RKYCK......KDY--VLRAQL........LSMEKSG.---------EWWQFTATVLTVYRQR....
NET5_MOUSE/314-431-------------QRYCQ......QDY--VLHAQVSASSSQ..PSEAVGP.---------EWWRLAVHVLAVFKQR....
NET5_HUMAN/361-468-------------RRYCQ......QDH--VLRAQV........LASEAAGP---------AWQRLAVRVLAVYKQR....
Q52KG2_MOUSE/457-570-------------KKFCR......KDY--AVQVAV........GARGEARG---------SWTRFPVAVLAVFRSG....
K7CDB2_PANTR/488-594-------------KKYCK......KDY--AVQIHI........LKADKAG.---------DWWKFTVNIISVYKQG....
O42203_DANRE/487-595-------------KKYCK......KDF--AVQVHV........LKGDKAG.---------EWWKFTINIISVYKQG....
NET3_CHICK/465-571-------------KKYCK......KDY--VVQVNI........LEMETVA.---------NWAKFTINILSVYKCR....
Q32SK9_DANRE/482-590-------------KKYCK......KDY--AVQVSV........LDMETVG.---------DWAKFSVSLMSVYKSR....
Q9NFW6_BRAFL/441-548-------------KNYCK......SGY--VIQCSI........LSREILG.---------EWTKFTINVGTIFKRE....
Q59JG2_HEMPU/509-616-------------NKYCK......KDY--VLHAHV........LSREMED.---------EWVKFTVNVVTVYKRG....
Q1PHQ2_SACKO/484-590-------------NKYCK......KDY--AVQANI........LSREQTT.---------DWVKFTINVMTVYKKG....

PF03146

H2XU25_CIOIN/62-176----------CLDRTTTEKN..STSTV--ILTGTV-----QYCDVIRAGS----------..YKCNIKIWRVMKGN----
T1EVC4_HELRO/36-148----------CFDLTIEEKV..NNAEF--IFSGTV-----REV.RYNVDK----------KAQKASVEIKRIFKGQ----
F7G642_MACMU/30-145----------CPERALERRE..EEANV--VLTGTV-----EEILNVDPVQ----------HTYSCKVRVWRYLKGK----
W4XF61_STRPU/38-146----------CQEYPVEKRE..EIANV--VISGYI-----HRIMR.KPRT----------IMYDCDIEVVRVFKGS----
K1QM75_CRAGI/2-104----------......EIRE..EMADV--VVTGTV-----KSVSALQRGS----------KLYSAVVEIKRVMKGE----
E5SMP2_TRISP/30-136----------CSDRQLSLQALIKRADV--ILSATV-----LSVKKLKSYS----------DFFEARISIRRIWKGE----
C3XQ33_BRAFL/36-153----------CHEDNLMKRV..RRATA--IVTGTV-----EQKMNGYPDG----------K.YKAKVRVWRVMKGT----
G3S0P3_GORGO/17-132----------CPERALERRE..EEANV--VLTGTV-----EEILNVDPVQ----------HTYSCKVRVWRYLKGK----
T1ISD8_STRMM/23-124----------CKDEALEVRE..EYATV--IFTGTV-----WRVFRTSEQK----------FTYSAEVKVRRVLKGG----
H2TJD1_TAKRU/9-124----------CPEKNLEDRE..EEANV--VLTGTV-----DEIINMDPVH----------NTYSCKVRVWRYLKGK----
T1KCH0_TETUR/42-143----------CRDKVPRKLT..DLSNV--VLTGFI-----EQTYPSLDNG----------EIYSGSVLVKRVFRGP----

PF00965

Q29AK5_DROPS/26-197-PEARRMLRDGRLATPNSDSM............CGIR.LDLG.-----------------.K-VYIIA----G.RMP...
Q1RLX2_DANRE/24-203-DR.....HIDVVFTAPSSAV............CGVTNLDTNG-----------------KK-EYLIS----G.KAEANG
A7SSJ2_NEMVE/18-205-GLVSKAGKPVAKQPEEGNPLVHNVKIYADRSPCPGW.LRAG.-----------------.T-DYLLA----G..LVDDG
TIMP2_CAVPO/25-203-EK.....DIEFIYTAPSSAV............CGVS.LDVGG-----------------KK-EYLIA----G.KAEGDG
TIMP3_BOVIN/22-194-TK...MPHVQYIHTEASESL............CGLK.LEVN.-----------------KY-QYLLT----G.RVY.DG
A7SSJ1_NEMVE/20-204-QIIRRTTGLQHRNTTLL..LPSEVRITTDDNACAAI.LPLN.-----------------.T-EQLIA----G..YSDGA
Q9GPJ2_CRAGI/21-203-SLLGSSDTLVIKTSGTPWN.............CGET.FTLN.-----------------.K-EYVIS----G..FVSDG
TIMP1_MOUSE/23-199-KAVGNAADIRYAYTPVMESL............CGYAHKSQNR-----------------SE-EFLIT----G.RLR.NG
TIMP4_RAT/28-207-EK...AKDIQYVYTPFDSSL............CGVK.LETNS-----------------QK-QYLLT----G.QILSDG
Q16IW9_AEDAE/30-198-PRAQKMLKQGKLITPSTDSM............CGIQ.LEVN.-----------------.Q-LYAIA----A.RDI...
TIMP1_HUMAN/22-199-QALGDAADIRFVYTPAMESV............CGYFHRSHNR-----------------SE-EFLIA----G.KLQ.DG
F6NH88_DANRE/71-248-NG.....EIDTIFTGPSSAL............CGVN.LESNG-----------------KQ-EYLIT----G.NLNSNG
H2LU60_ORYLA/26-204-SH.....DIDAVYTAPSSSL............CGVS.MDTTG-----------------KK-EYLIT----G.KLETDG
H2SZH2_TAKRU/30-202-DK...VQHVQHIYTDASESL............CGVK.FDIN.-----------------KY-QYLIT----G.RVY.DD
H2USP3_TAKRU/28-207-DK...AKDIQYVYTPVFSSL............CGVK.LDYNN-----------------KA-GYLLS----G.SMWRDG
H3C979_TETNG/26-206-NQ.....DVEAVLTAPVSAV............CGVT.LDASG-----------------RK-EYLIS----G.KEEGGG
H3CWM8_TETNG/28-206-TQ.....DIEAIYTPPSSAM............CGVS.LQAN.-----------------GK-EYLIT----GGKLNADG

PF01759

Q8WPD8_CIOIN/1602-1707.SDNVQNGTVRTFVIRND...------------CHASCRDT..-----------------DE.DLRLL.....-----RN
Q8I7P1_9CNID/1611-1718VTKKITKKTARIVYSKKIS..------------CDCPVFAGKI-----------------DR.HFLIM....G-----KD
Q8MX24_ANCCA/29-132..DRKIPIELFSWREKEN...------------CGVPDLEE..-----------------GK.EYLIG....G-----KV
Q5NKN5_CARRO/1605-1719QKQNILHTSKDLMVRDS....------------CSVADLDI..-----------------QQ.EYVIM....G-----RD
CO3_EPTBU/1496-1605MDQAINVGARRSFVIPMH...------------CGKN.LNVSP-----------------GD.IYLVM....G-----MH
CO3_LETCA/1543-1654QDQAIQPKATRLFIVTRS...------------CDGR.LGMET-----------------PR.QYLLM....G-----RK
Q9I933_CYPCA/1566-1681LDSGIQKHATRQMILRLS...------------CDELELKK..-----------------EV.HYLIM....G-----QN
Q91741_XENLA/1554-1664SDEDIKPEDTRLFYQPMS...------------CK...MRLAK-----------------ET.EYLIM....G-----QD
Q76KI4_TRISC/1564-1675KDDDVKIGEVRHFLSQRS...------------CK...FQLKE-----------------GD.EYLVM....G-----QD
Q9I932_CYPCA/1587-1697GDLSVSADSTRVFAKRKH...------------CKSD.LKE..-----------------GK.TYLIM....G-----ND
Q7SZG2_TAKRU/1574-1684GDVSVKVDSVRVFLKRGQ...------------CKAN.LDL..-----------------GK.EYLIM....G-----KD
Q4RHV3_TETNG/135-245EDIGVMEGSIRVFAKRRQ...------------CKVQ.LDL..-----------------RK.DYLIM....G-----KD
Q70TF5_ONCMY/1595-1705GDVKLEESKVRVLAKRLQ...------------CKGQ.LET..-----------------GK.TYLIM....G-----KD
Q9IBG9_ORYLA/1588-1699DLLVKKENSVRVFAKRLQ...------------CKGQ.LEV..-----------------GN.QYLIM....G-----KD
Q076D6_CHICK/1536-1646QDTAVAPGERRRLLVRKS...------------CP...LRLQL-----------------HN.IYLVM....G-----GS
CO4A_HUMAN/1615-1725KDVKAAANQMRNFLVRAS...------------CR...LRLEP-----------------GK.EYLIM....G-----LD
Q62238_MOUSE/465-575TDTMASIGQTRNFLSRTS...------------CR.LRLEP..-----------------NK.EYLIM....G-----MD
Q969A4_BRABE/1602-1713.LDDVFDGEERVFWKRKT...------------CSGLQLVE..-----------------GT.TYLLM....G-----KD
Q8AYN9_CYPCA/1560-1672QTDDLKTDSEIDLVKKAT...------------CSSTNFEV..-----------------GK.QYLIM....T-----AE
Q4SXM5_TETNG/1606-1718ELEAVSSGTPVELVKRAT...------------CTSVEIQE..-----------------NQ.QYLLM....G-----SG
Q6VPV1_PIG/1548-1659.EAVAEKGSEITFIKKTT...------------CTNANLEK..-----------------GK.QYLIM....G-----KE
Q99KX9_MOUSE/254-364..EAADENSEVTFIKKMS...------------CTNANLVK..-----------------GK.QYLIM....G-----KE
CO5_HUMAN/1550-1661.EAVAEKDSEITFIKKVT...------------CTNAELVK..-----------------GR.QYLIM....G-----KE
Q4SVH8_TETNG/1716-1828VEPGVQPGHRRFFMAHGG...------------CRDG.LELKL-----------------GS.QYLIM....G-----PK
A5PMP6_DANRE/1549-1662TEEGLNEKERRMFLSHAS...------------CRTR.LNLKE-----------------GQ.EYLVI....G-----PI
Q9W6G1_PROAT/775-885.SDDAQKGSQKIFITHSN...------------CREI.LSLKI-----------------DK.QYLVK....G-----HI
Q91588_9PIPI/1460-1570.TDEDPEDKTRNFISHIK...------------CRKA.LNMQL-----------------NR.DYLIW....G-----VT
VCO32_AUSSU/1522-1632.TDRNPQAKARQYVSQRK...------------CQEA.LNLNL-----------------NN.DYLIW....G-----LS
VCO3_NAJKA/1513-1623.TDENPRAKTHQYISQRK...------------CQEA.LNLKV-----------------ND.DYLIW....G-----SR
Q90633_CHICK/1523-1633.TDENPGGSNRTFVSHKQ...------------CRDA.LSLQK-----------------GQ.DYLVW....G-----LA
Q3L2T4_MACEU/1523-1632.SDENAQGKIQTFISHVK...------------CRDA.LLLKE-----------------GK.DYLIW....G-----IS
CO3_RABIT/597-707.SDEVQAGQPAPFISHIK...------------CRDA.LKLKD-----------------GK.HYLMW....G-----LS
CO3_BOVIN/1532-1642.SDEVQVKQERKFISHIK...------------CREA.LKLKE-----------------GA.HYLVW....G-----VS
A6MK21_CALJA/94-204.TDEVQVGQQRTFISPIK...------------CREA.LKLEK-----------------GK.LYLMW....G-----LS
CO3_RAT/1534-1644.SDEVQAGQERRFISHVK...------------CRNA.LKLQK-----------------GK.QYLMW....G-----LS
Q9DDV9_ONCMY/1553-1662.TDLVLEGGKRLFLAHPS...------------CREA.LDLKE-----------------GQ.SYLLI....G-----DT
Q98977_ONCMY/1484-1594.TDLLLNGEKRLFLAHPS...------------CRKA.LDLEE-----------------GQ.SYLLM....G-----DT
Q3L5A8_GADMO/75-188.SDKEPSGKLRTFIGYSH...------------CRET.LNLKT-----------------NA.SYLIM....G-----TV
Q98TS6_ANAMI/1526-1643SKDVGPLNKERTLLSYPH...------------CRDP.LDLRT-----------------GN.NYLIM....G-----AS
Q4S019_TETNG/1311-1428NNDVAPKGKQRIFLGYPH...------------CRAA.LDLKK-----------------DK.NYLIM....G-----AS
Q9IBH1_ORYLA/1522-1639STDVGPRGKLRPFLSYPH...------------CRDA.LNLQK-----------------GK.TYLIM....G-----SS
Q4RJA3_TETNG/792-902SYDVGPQGKQRVFLGFPN...------------CRKS.IGLVK-----------------GK.TYLIM....G-----LS
Q4RZT6_TETNG/1515-1632NTDVAPQGKQRPFLSYPH...------------CRES.LNLTK-----------------GK.TYLLM....G-----SS
CO3_ONCMY/1507-1621.TDEGVEGKNRDFMGLAY...------------CREA.LGLMQ-----------------GK.TYMIM....G-----KS
Q3MU73_DANRE/1522-1632.TDPDVEGKVKPFLARPS...------------CRVS.LGLVE-----------------GK.SYLIM....G-----NS
Q9YIA6_CYPCA/1030-1140.TDVNVEGKVRPFFARPS...------------CREY.LGLLE-----------------GK.SYLIM....G-----KS
Q6UAQ6_CTEID/1510-1620.TDEDVEGRVRLFLARPS...------------CRED.LGLVK-----------------GK.SYLIM....G-----KS
Q9YIA9_CYPCA/1513-1623.TDVDVEGKRRPFLARPT...------------CRNH.LGLVE-----------------GK.SYLIM....G-----RS
Q4S5G7_TETNG/453-556GLRFFGKEPLEVTLLNMDWN.------------CPCPNITT..-----------------ANEQLVVM....G-----DV
O44344_STRPU/1565-1680DEDVPHQAQRQLFINEG....------------CDCPKVKGRN-----------------IGGTFLLV....G-----QK
A7SX91_NEMVE/256-359...LSEPAEMLIRVPGGK...------------CPCPPLRV..-----------------GE.NYVLM....G-----SM
Q4RGB2_TETNG/197-294GLKKKELKSLVLYLKNGAD..------------CPCQQLDQ.L-----------------GH.HYLVM....G-----RR
A3KNP6_DANRE/185-282SMKKQDLKKLVLYLKSGAH..------------CPCQQLEN.L-----------------EN.HYLIM....G-----RS
Q32PN6_DANRE/181-278TLKKKDLKKLTLYLKNGAD..------------CPCTQLDN.T-----------------RN.TYLIM....G-----RK
Q6GZK1_ORYLA/191-288NLKKRDLKKLTLYLKNGAN..------------CPCQQLEN.L-----------------EN.QYLIM....G-----RK
Q3KQ69_XENLA/197-293PIQKKDWAELVLYLKNGAN..------------CPCHQLDQLK-----------------G..QFLVL....G-----RK
SFRP5_HUMAN/195-293PLKRKDTKRLVLHMKNGAG..------------CPCPQLDSLA-----------------G..SFLVM....G-----RK
Q4SKX3_TETNG/205-303ALRKKDLKKLTLYIKNGAN..------------CPCSQLDS.L-----------------GS.NFLIM....G-----RK
SFRP1_MOUSE/200-296PIKKKELKRLVLFLKNGAD..------------CPCHQLDN.L-----------------SH.NFLIM....G-----RK
SFRP1_CHICK/200-296PIRKKNLKKLVLLLKNGAD..------------CPCHQLDN.L-----------------GH.HFLIM....G-----RQ
A4IGU5_XENTR/180-278GWSDEELRKTVLWLSDGDN..------------CLCQDIHE.P-----------------GA.TVLVL....G-----HR
L8I1X6_9CETA/186-284GVSEKDLKKSVLWLKDSLQ..------------CTCEEMND.I-----------------NA.PYLVM....G-----QK
Q7ZXM6_XENLA/190-288GVTERDLKKTVLWLKDGLQ..------------CTCDEMND.I-----------------NA.PYLVM....G-----QK
Q32SK8_DANRE/445-554TRLRLSRGSRTLYPESWMSRG------------CTCPVLFP..-----------------GGLEYLVV....G-----HE
Q0VEM1_MOUSE/517-624.KLKILRGKRTLYPESWTNRG------------CTCPILNP..-----------------GL.EYLVA....G-----HE
Q4RSD5_TETNG/491-599AGMKIRRGSATLYPESWTEQG------------CTCPILNP..-----------------GS.EYVVA....G-----HQ
Q4S5B2_TETNG/454-562TKVKIQRGRATLYPESWTARG------------CTCPILNP..-----------------GG.EYLVA....G-----HS
Q2HJB6_BOVIN/340-444.GLDLPSPPTDTLLKFYVPC.------------KQCPPMKK..-----------------GI.SYLLM....G-----QV
Q3UIP2_MOUSE/353-457.GLDLPSPPSGTSLKLYVPC.------------RQMPPMKK..-----------------GA.SYLLM....G-----QV
PCOC1_HUMAN/330-434.GLDLPSPPTGASLKFYVPC.------------KQCPPMKK..-----------------GV.SYLLM....G-----QV
Q7ZWR8_XENLA/379-484.GLSIQESGKTMSIKVINEC.------------PKCPILKK..-----------------GS.SYLFM....G-----EV
Q66IT1_XENLA/372-477.GLSIQGSGKTMSIKVINEC.------------PKCPILKK..-----------------GS.SYLFM....G-----EV
Q1RMV2_BOVIN/310-413.NLAIQQAGKNMSAKVLVVC.------------KQCPLLRR..-----------------GL.NYIIM....G-----QV
PCOC2_MOUSE/308-411.NLAIQQAGKNMSVKLTVVC.------------RQCPLLRR..-----------------GL.NYIIM....G-----QV
Q4S4Z9_TETNG/252-355.NLAIQQAGKTMSTKIVILC.------------KKCPFVRR..-----------------GL.NYVFT....G-----QV
Q52L01_XENLA/302-405.TLAIQQAGKNMSAKITVVC.------------KQCPMVRR..-----------------GL.NYIIM....G-----QV
SFRP4_HUMAN/188-289..SPIPRTQVPLITNSS....------------CQCPHILP..-----------------HQ.DVLIM.....-----..
O08570_MESAU/127-229.LVNIPRDTVNLYTTSG....------------CLCPPLHV..-----------------NE.EYIIM....G-----YE
Q32N13_XENLA/189-292.LVNIPKDTVTLYTNSG....------------CLCPQLVA..-----------------NE.EYIIM....G-----YE
Q9W6E0_DANRE/200-303.LVNIPRDTVTLYYNSG....------------CLCPPLTA..-----------------ND.EYIIM....G-----YE
Q4S9P7_TETNG/197-299.LVNIPKETHTLYYSSS....------------CLCPPLAI..-----------------GE.EYLIM....G-----YE
X6R4H8_HUMAN/364-467...SPLRAREYVWAPGH....------------CPCPMLAP..-----------------HR.DYLMA....V-----QR
A7SBN2_NEMVE/182-284...AVRITKRQLLELRGRELT------------CNCSQVLP..-----------------SK.VYLII....G-----KE
Q9NL28_CIOIN/535-642GMRLKKKEMIDIQVRDRVLQ.------------CLCPRLRV..-----------------NR.TYLLL....G-----KY
Q95YK2_CIOSA/556-663VVRFRKKERVDVEVRDRIVH.------------CLCPKLQV..-----------------KK.TYLLI....G-----KY
A0A9Q8_MOLTE/181-286QNRKFVKGRQVLRARGTHIKP------------CNCTKLLLGA-----------------GK.KYLIF.....-----..
A7SHI5_NEMVE/436-545RTRRVRRGDGYVWIKKRDFR.------------CRCPKLKP..-----------------GR.SYFIA....G-----NL
UNC6_CAEEL/491-597.TENMQRGETSLWISPQGVI.------------CKCPKLRV..-----------------GR.RYLLL....G-----KN
Q0IGC3_AEDAE/141-257ATSSQRKSSVGLLVPSKNLD.------------CRCPSIKI..-----------------NK.SYLIL....G-----MD
O96659_HIRME/495-600.KDRLRRGEDTVWVSTKDLN.------------CRCPRLRV..-----------------KQ.SYLVV....G-----KD
Q4SF52_TETNG/899-1011SASRVRKGPHSLWVPDRDLR.------------CGCPALHV..-----------------GR.TFLLI....G-----TV
Q0V9H1_XENTR/485-591.RVPIRRGDQPLWVPDHDLA.------------CDCLRVQV..-----------------GK.SYLII....G-----ND
NET5_MOUSE/314-431.AWPVRRGGQEAWVPRADLI.------------CGCLRLRP..-----------------GA.DYLLL....G-----RA
NET5_HUMAN/361-468.AQPVRRGDQDAWVPRADLT.------------CGCLRLQP..-----------------GT.DYLLL....G-----SA
Q52KG2_MOUSE/457-570.EERARRGSSALWVPTLDAA.------------CGCPRLLP..-----------------GR.RYLLLGGGPG-----AA
K7CDB2_PANTR/488-594.TSRIRRGDQSLWIRSRDIA.------------CKCPKIKP..-----------------LK.KYLLL....G-----NA
O42203_DANRE/487-595.GHRIRRGDQLLWVRAKDVA.------------CKCPKIKP..-----------------GR.KYLLM....G-----SD
NET3_CHICK/465-571.DERVKRGDNFLWIHLKDLS.------------CKCPKIQI..-----------------SK.KYLVM....G-----IS
Q32SK9_DANRE/482-590.GDPLKRGDHMLWVHMKDLA.------------CKCPRIHM..-----------------GK.RFLIL....G-----ST
Q9NFW6_BRAFL/441-548QSLKLRRGDQYMYVRQSDLQ.------------CKCPKLRL..-----------------GR.KYLLM....G-----SV
Q59JG2_HEMPU/509-616.EQRIRRGNTFLYVRQRDLT.------------CKCPKIRL..-----------------RH.RYLIL....G-----DE
Q1PHQ2_SACKO/484-590.QNKIRRGDQILYVHNRDLT.------------CKCPKLRL..-----------------GR.KYLII....G-----ND

PF03146

H2XU25_CIOIN/62-176--SL..............---------------.AMNLI.TIQKQGILTSMYKKKYVDVYGL----------G-----NS
T1EVC4_HELRO/36-148--HKLTQLFLSEIKGRFL---------------PIVHKVCTVE.................GL----------G-----LD
F7G642_MACMU/30-145--ELVARESLLD......---------------.GGNKV.VIS.................GF----------G-----DP
W4XF61_STRPU/38-146--EALYSNVVPPM.....---------------.DGNTI.QIG.................GF----------G-----DP
K1QM75_CRAGI/2-104--DLLGESSVSN......---------------.AGQEV.LVQ.................GF----------G-----DP
E5SMP2_TRISP/30-136--HLIPSRRF........---------------...GQL.TVQ.................GI----------A-----NP
C3XQ33_BRAFL/36-153--NEIPTANRVQPLRDPS---------------RGVAEV.MVD.................GF----------G-----DP
G3S0P3_GORGO/17-132--DLVARESLLD......---------------.GGNKV.VIS.................GF----------G-----DP
T1ISD8_STRMM/23-124--DHVNADTL........---------------.....V.VID.................EI----------G-----TP
H2TJD1_TAKRU/9-124--SSVDREILLD......---------------.GGNKV.MIG.................GF----------G-----NP
T1KCH0_TETUR/42-143--SKF.............---------------.QGNRV.TID.................GL----------G-----DA

PF00965

Q29AK5_DROPS/26-197..TLNVCSYYKEYTKMTITERHG------FSGGYGKSCN.CTVSPCFGQQCLR..HREYSDGCKWSPFGKCERDYSACMP
Q1RLX2_DANRE/24-203KMHVTLCDLIMPWESMSATQKKS------LSQRYQMGCD.CKITRCATFPCE....ISAPEECLWTDW.VTEKIIHGRQS
A7SSJ2_NEMVE/18-205KLFISSCHWTSPWQQVTQAQRLG------VQSVYGESCR.CRVTSCS.........FLGPGGLILDSH.........CSE
TIMP2_CAVPO/25-203KMHITLCDFIVPWDTLSTTQKKS------LNHRYQMGCE.CKITRCPMIPCY....ISSPDECLWMDW.VTEKSINGHQA
TIMP3_BOVIN/22-194KMYTGLCNFVERWDQLTLSQRKG------LNYRYHLGCN.CKIKSCYYLPCF....VTSKNECLWTDM.FSNFGYPGYQS
A7SSJ1_NEMVE/20-204RLEVFSCNWVEPWGNLTVSQQIA------VKRYYGRHCA.CRTSLCS.........LLDPLGTLLDFE.........CAR
Q9GPJ2_CRAGI/21-203EFFTNNCQWNPEYLTLEPHQRRG------IRYMYEQGCN.CTIHHCRGENCDFPQSLNPDQTCIWPGS....YNTNDCYA
TIMP1_MOUSE/23-199NLHISACSFLVPWRTLSPAQQRA------FSKTYSAGCGVCTVFPCLSIPCK....LESDTHCLWTDQ.VLVGSE.DYQS
TIMP4_RAT/28-207KVFIHLCNYIEPWEDLSLVQRES------LNHHYHQNCG.CQITTCYAVPCT....ISAPDECLWTDW.LLERKLYGYQA
Q16IW9_AEDAE/30-198..HVGLCNFVRKYSDLTIVEKRG------LAGIYRKGCS.CQIKPCFSGEC.....NMTIGACNWTPWASCETDYGSCIP
TIMP1_HUMAN/22-199LLHITTCSFVAPWNSLSLAQRRG------FTKTYTVGCEECTVFPCLSIPCK....LQSGTHCLWTDQ.LLQGSEKGFQS
F6NH88_DANRE/71-248TLRINLCDYIESWESLSLTQKKS------LGPRYQMGCD.CKIVQCPIIPCS....ISEPVECLWTDW.VLEGTVQGTQA
H2LU60_ORYLA/26-204TMHVTLCDFIDQWDAMTATQKKN------LIQRYESSCD.CKITHCTSIPCV....LSSPTECLWTDW.VIEKTVKGEQA
H2SZH2_TAKRU/30-202KVYTGLCNFNERWERLSLAQKKG------FNHRYQLGCN.CRIKPCHYLPCF....VTSKNECLWTDM.LSNLGYPGYQS
H2USP3_TAKRU/28-207RISVGQCDLVESWDNLSLSQKKN------LNYRYQIGCE.CRINTCYTVPCV....STGENECLWTDW.LLDNSLNGEQA
H3C979_TETNG/26-206RVHVTLCDYIMPWEALSAAQKKG------LSQRYQMGCE.CKIVRCPSLPCE....VSAPEECLWTDL.VLEKLVYGRQA
H3CWM8_TETNG/28-206TLHVTLCDFIELWESTSATQKKS------LTQRYEMGCD.CKITRCTSIPCL....ISSPSECLWTDW.VMEKAVYGQQA

PF01759

Q8WPD8_CIOIN/1602-1707NIPAKDTRLFKEGR..VLLITGS------LIE....RRQ-NRNRLLQT--------------------------------
Q8I7P1_9CNID/1611-1718V........GLRGSSKVVLGHNV------FVKEWPMND.-.PVDFFKK--------------------------------
Q8MX24_ANCCA/29-132T.......DYGDGDLVISVSRCD------LLRNW.TDVS-GEEKKLLG--------------------------------
Q5NKN5_CARRO/1605-1719G.AQFKDEDTGILLYRYILDQST------SIFKWTRISV-AENKQLTK--------------------------------
CO3_EPTBU/1496-1605N.....AHWRNSDRTQYVLTSDT------WFEKFPLESV-CRLPSPPA--------------------------------
CO3_LETCA/1543-1654G...ETKDRNDRFQ..YVLDASS------WVEQWPVDEK-CNQPNVQT--------------------------------
Q9I933_CYPCA/1566-1681DAISVLNNDGQHFR..YVLNNDM------WIEKMPEEKN-CKATKNRA--------------------------------
Q91741_XENLA/1554-1664G...VTKNEHGHIR..YILEKNF------WVEELPGEQK-CAATRYRN--------------------------------
Q76KI4_TRISC/1564-1675G...TTSDTSRKMQ..YLLDVKS------WVEAIPPEDI-CELRKYRS--------------------------------
Q9I932_CYPCA/1587-1697G...PTKDLNGNMQ..YLLDSKT------WVEEKLSPST-CRASVNKG--------------------------------
Q7SZG2_TAKRU/1574-1684G.....STRDSRGMIQYLLESNT------WVERKPLPIN-CGKSAHRP--------------------------------
Q4RHV3_TETNG/135-245G.....STRDSRGMMLYLLESNT------WVEMKPPQDS-CKKSANRN--------------------------------
Q70TF5_ONCMY/1595-1705G...STTDSNGQMQ..YLLESKT------WIEQVPNEKK-CQGSKNRP--------------------------------
Q9IBG9_ORYLA/1588-1699G...STTDTDGKMQ..YLLESDT------WVEKMPSAED-CKKSFNKN--------------------------------
Q076D6_CHICK/1536-1646G...RTRDPEGRPQ..FLLGPHS------WLEEVPSPGR-CKATRLRG--------------------------------
CO4A_HUMAN/1615-1725G...ATYDLEGHPQ..YLLDSNS------WIEEMPSERL-CRSTRQRA--------------------------------
Q62238_MOUSE/465-575G...ETSDNKGDPQ..YLLDSNT------WIEEMPSEQM-CKSTRHRA--------------------------------
Q969A4_BRABE/1602-1713GTKYTDEQGFDSFR..YVITEQS------FVAEWPTGAK-AERKKFKR--------------------------------
Q8AYN9_CYPCA/1560-1672S...IKIRMNRGYKYKFPLDSRA------WVDWWPLDTD-CRDDACIQ--------------------------------
Q4SXM5_TETNG/1606-1718G...SEIRLERSFRYRLPLDSEA------LLELWPT..D-CGSPECLD--------------------------------
Q6VPV1_PIG/1548-1659A...LQIKHNFNFKYIYPLDSST------WIEYWPTDTA-CPSCQTFL--------------------------------
Q99KX9_MOUSE/254-364V...LQIKHNFSFKYIYPLDSST------WIEYWPTDTT-CPSCQAFV--------------------------------
CO5_HUMAN/1550-1661A...LQIKYNFSFRYIYPLDSLT------WIEYWPRDTT-CSSCQAFL--------------------------------
Q4SVH8_TETNG/1716-1828EDRWSIDSSTNQFL..YMLGKDT------WVERWPTPAE-CSSTGSLP--------------------------------
A5PMP6_DANRE/1549-1662TDVWNAGSTVSN.KYVYTLGKET------WVERWPDESE-CGSTLQKK--------------------------------
Q9W6G1_PROAT/775-885T.....DLWNLQKEMAYVIGKNT------LLEWWPNDVE-CQDIQYQK--------------------------------
Q91588_9PIPI/1460-1570G.....DLWRQPDGYSYIIGKDT------WMEWWPNERE-CQQRENQD--------------------------------
VCO32_AUSSU/1522-1632S.....DLWPMKNDISYLITKNT------WIERWPNEDE-CQDEEFQN--------------------------------
VCO3_NAJKA/1513-1623S.....DLLPTKDKISYIITKNT------WIERWPHEDE-CQEEEFQK--------------------------------
Q90633_CHICK/1523-1633S.....DLWVTGSRFSYLISKDT------WLEAWPLEES-CQDADLQP--------------------------------
Q3L2T4_MACEU/1523-1632S......DLWKMKELNYIIGKDT------WVELWPQEDE-CQDEEYQK--------------------------------
CO3_RABIT/597-707S.....DPVGEKPNTSYIIGKDT------WVEFWPEKEE-CQDEENQK--------------------------------
CO3_BOVIN/1532-1642S.....DLWGEKPKISYIIGKDT------WVELWPEAEE-CQDEENQK--------------------------------
A6MK21_CALJA/94-204S.....DFWGEKPNISYIIGKDT------WVEHWPEEDE-CQDEENQK--------------------------------
CO3_RAT/1534-1644SDLW.....GEKPNTSYIIGKDT------WVEHWPEAEE-RQDQKNQK--------------------------------
Q9DDV9_ONCMY/1553-1662A......DLIQSVTDRYVLGERT------WIEYWPTSDE-CNMQDQEK--------------------------------
Q98977_ONCMY/1484-1594A...ALIQSGDRFE..YVLGERT------WIESWPTSDE-CSIQGPTR--------------------------------
Q3L5A8_GADMO/75-188K....NAQKVGRNQYEYLLGEQS------WIEYWPTPLE-CQNPKYGS--------------------------------
Q98TS6_ANAMI/1526-1643T...DIYRDDQAQSHQYVLGERT------WIEYWPTDKQ-CQTEEYRR--------------------------------
Q4S019_TETNG/1311-1428R.DIHMDREEKMYQ..YALGEKT------WVEYWPTEAE-CKTVQHRP--------------------------------
Q9IBH1_ORYLA/1522-1639R...DIHKDEKQLTYQYVLGERT------WIEYWPTAEE-CQGDEHRA--------------------------------
Q4RJA3_TETNG/792-902T...DIYKDEKNQMYQYVLGERT------WIEYWPTVAE-CQTDEYRP--------------------------------
Q4RZT6_TETNG/1515-1632K...DIHGGEKGEAFQYVLGERT------WVEYWPTQEE-CQTEEHTE--------------------------------
CO3_ONCMY/1507-1621E.DLHRVEDKGLLQYKYVLGEQT------WIEYWPSQQE-CTSRDYRE--------------------------------
Q3MU73_DANRE/1522-1632V...DLPTLGGSLQ..YIIGEQT------WIEYWPTSDE-SKSAEHRD--------------------------------
Q9YIA6_CYPCA/1030-1140V...DLPELRGSLQ..YVFGEQT------WVEYWPTREE-SQTREHRE--------------------------------
Q6UAQ6_CTEID/1510-1620T...DLPKLGGSLQ..YILGEKN------WVEYWPTREE-SQMKKYRD--------------------------------
Q9YIA9_CYPCA/1513-1623V...DLPDLGGSLQ..YIFGEQT------WIEYWPTRKE-SQTQEHRD--------------------------------
Q4S5G7_TETNG/453-556H............NGMAVLQPDS------FVTL...SSA-RKIRKLRE--------------------------------
O44344_STRPU/1565-1680SLKYTTEQGEERYR..YVYGPTS------KLEFWPATRK-ARNAAVFD--------------------------------
A7SX91_NEMVE/256-359R.......TTSKGKTRMRLTPKN------FVREWSLEFN-SKVEDYKR--------------------------------
Q4RGB2_TETNG/197-294V...................EQH------FLLTGIHKWD-KSSKEFRK--------------------------------
A3KNP6_DANRE/185-282V...................GKQ------YVLTGIHKWD-NSSKDFKK--------------------------------
Q32PN6_DANRE/181-278V...................DKQ------YLLTGIHKWD-KSNREFKK--------------------------------
Q6GZK1_ORYLA/191-288V...................DKQ------FLLTGIHKWD-KSSKEFKK--------------------------------
Q3KQ69_XENLA/197-293A...................KAQ------HLLTAIHKWD-KTNREFNR--------------------------------
SFRP5_HUMAN/195-293V...................DGQ------LLLMAVYRWD-KKNKEMKF--------------------------------
Q4SKX3_TETNG/205-303V...................DQQ------LLLMSIHKWD-KKSKELKF--------------------------------
SFRP1_MOUSE/200-296V...................KSQ------YLLTAIHKWD-KKNKEFKN--------------------------------
SFRP1_CHICK/200-296V...................KTQ------HLLTAIYKWD-KKNKEFKK--------------------------------
A4IGU5_XENTR/180-278A...................DDR------LVISWVRKWQ-KSEKETKR--------------------------------
L8I1X6_9CETA/186-284L...................GGE------LVITSVKRWQ-KGQREFKR--------------------------------
Q7ZXM6_XENLA/190-288L...................GGE------LVITSVKRWQ-KGQQKFKR--------------------------------
Q32SK8_DANRE/445-554D........VRKGR..PVVNMKS------IVKPWRASLS-RKVHQLLK--------------------------------
Q0VEM1_MOUSE/517-624D........VRTGK..LIVNMKS------FVQHWKPALG-RRVMHILK--------------------------------
Q4RSD5_TETNG/491-599D........WKTGR..PVVNTKS------LVKPWRSSLG-RKFLHILR--------------------------------
Q4S5B2_TETNG/454-562D........RKQGR..LLVNMKS------FVKPWKASLG-RKVLTLLK--------------------------------
Q2HJB6_BOVIN/340-444D........KNRGP...ILPPES------FVVLHRPTQH-QILTNLSR--------------------------------
Q3UIP2_MOUSE/353-457E........ENRGP...ILPPES------FVVLYRSNQD-QILNNLSK--------------------------------
PCOC1_HUMAN/330-434E........ENRGP...VLPPES------FVVLHRPNQD-QILTNLSK--------------------------------
Q7ZWR8_XENLA/379-484N.......AEGQGR....IVPES------FVIAHKAAQH-QILTAISK--------------------------------
Q66IT1_XENLA/372-477N.......AEGQGR....IVPES------FVIGYKVAQH-QFLTAISK--------------------------------
Q1RMV2_BOVIN/310-413G.......EDGRGK....IMPNS------FIMMFKTKNQ-KLLDALKN--------------------------------
PCOC2_MOUSE/308-411G.......EDGRGK....IMPNS------FVKMFKNKNQ-KPMNALKN--------------------------------
Q4S4Z9_TETNG/252-355D.......EDGRGK....IAPHH------FVMAFKTKNQ-KGLNVLKN--------------------------------
Q52L01_XENLA/302-405D.......EDGRAK....VLPSN------YVMTFKTKNQ-KILNTLKN--------------------------------
SFRP4_HUMAN/188-289.......CYEWRSR..MMLLENC------LVEKWRDQLS-KRSIQWEE--------------------------------
O08570_MESAU/127-229D........EERSR..LLLVEGT------IVEKWKDRXG-XKVKRWDM--------------------------------
Q32N13_XENLA/189-292D........KERTR..LLLVEGS------LAEKWRDRLA-KKVKRWDQ--------------------------------
Q9W6E0_DANRE/200-303N........EERSR..LLLIDRS------IAQKWKEKIG-RKVKRWDQ--------------------------------
Q4S9P7_TETNG/197-299N........EERSR..LLLIDGS------IAQKWKDKMT-RKIKRWDQ--------------------------------
X6R4H8_HUMAN/364-467L......VSPDGTQDQLLLPHAG------YARPWSPAED-SRIRLTAR--------------------------------
A7SBN2_NEMVE/182-284D..........KHRRVLFVDGMV------SALEW.DVDG-KKMARMIR--------------------------------
Q9NL28_CIOIN/535-642A......RSDGNLR..MTIDKNS------VIISWLNKYK-KMLRRVAK--------------------------------
Q95YK2_CIOSA/556-663N......RSGGEPR..LAIDKGT------IVMEWKNKYK-RRLRSLQR--------------------------------
A0A9Q8_MOLTE/181-286..........SSYSKPFILDPSD------SVLPWRDGYQ-NKLNRYTK--------------------------------
A7SHI5_NEMVE/436-545R........GQSRKRSIVLNGRS------VVLPWNEKLL-KRIYRFIK--------------------------------
UNC6_CAEEL/491-597D........SDHERDGLMVNPQT------VLVEWEDDIM-DKVLRFSK--------------------------------
Q0IGC3_AEDAE/141-257S.........KQNPDSLVLGPKT------IIIEWKDDWN-RRLRRFQQ--------------------------------
O96659_HIRME/495-600S.......SSSRGG..IILDQTS------LVVPWSEQQA-LRIKQITK--------------------------------
Q4SF52_TETNG/899-1011E....GERAWGPEESRLVADRST------LALQWREHWG-HKLRGFRG--------------------------------
Q0V9H1_XENTR/485-591E......ESPDPAR..LILDKNS------LALPWRDVWG-HKLRRFQQ--------------------------------
NET5_MOUSE/314-431A...QTHDDDNYDPARLILNRHG------LALPWRPRWA-RPLRRLQQ--------------------------------
NET5_HUMAN/361-468V........GDPDPTRLILDRHG------LALPWRPRWA-RPLKRLQQ--------------------------------
Q52KG2_MOUSE/457-570A...GSTAGRGQ.G..LSAARGS------LVLPWRDAWT-RRLRRLQR--------------------------------
K7CDB2_PANTR/488-594E......DSPDQSG..IVADKSS------LVIQWRDTWA-RRLRKFQQ--------------------------------
O42203_DANRE/487-595E......EEDSRGQSGVVADRGS------LLIPWKDLWA-RRLRKFQQ--------------------------------
NET3_CHICK/465-571E......NSTDRPG..LMADKNS------LVIQWRDAWT-RRLRKLQR--------------------------------
Q32SK9_DANRE/482-590E....GTANPERPG..LQADKNS------LVIQWRDIWT-RRLRKFQR--------------------------------
Q9NFW6_BRAFL/441-548D......SNNNREG..LTLDYRS------TSIPWRNRWG-KRLRRLQR--------------------------------
Q59JG2_HEMPU/509-616D.......DSSSKRDGIVVDNKS------IVLKWRDEWD-MRMRKFQR--------------------------------
Q1PHQ2_SACKO/484-590N......KNPNQNG..LLADHKS------YVIPWRDDWN-RRMRKFQR--------------------------------

PF03146

H2XU25_CIOIN/62-176AFCKSNVERADTRI--FFLNKLN........NRLVVSASLDRITLKNL--------------------------------
T1EVC4_HELRO/36-148GLCSSHTRVFDTWL--FFTNPVD........DKLQLNSSLVRLSVM..--------------------------------
F7G642_MACMU/30-145LICDNQVQVGDVSV--YAGWPGIPIVWPCVWTRGLMPASFPNMSLRGL--------------------------------
W4XF61_STRPU/38-146AICDNAVTPGETRI--FMMNKNG.......NGHLMLNSSVIRITLNNL--------------------------------
K1QM75_CRAGI/2-104RFCENTVRVFDTRI--LMLSLDD.......GGILRLNSSVVRISLRNL--------------------------------
E5SMP2_TRISP/30-136SICHSRAVEKDTKI--FLLKLLK.......DGRIQLDSSLLSINLANL--------------------------------
C3XQ33_BRAFL/36-153HICDNEVDQGDTRI--FLLDKKP....AGPPDEFELTSSLIRVTLDNL--------------------------------
G3S0P3_GORGO/17-132LICDNQVSTGDTRI--FFVNPAPPYLWPAHKNELMLNSSLMRITLRNL--------------------------------
T1ISD8_STRMM/23-124LICRNRVREKDTRI--FFLTQGV........NHLRFNSSVIRMTMANL--------------------------------
H2TJD1_TAKRU/9-124QICDNQVATGDTRI--FFLNPSSLSMGPEHKNELKLNSSLMRITLRNL--------------------------------
T1KCH0_TETUR/42-143SYCQSKGQRGESWI--FQLSQIS.......DGYFRLNGTLLKLNLDNL--------------------------------

PF00965

Q29AK5_DROPS/26-197HVTHT.VNGSISRCRW
Q1RLX2_DANRE/24-203DHYAC.IKRGDGSCAW
A7SSJ2_NEMVE/18-205GYLYC..GEHGLSCAW
TIMP2_CAVPO/25-203KFFAC.IKRSDGSCAW
TIMP3_BOVIN/22-194KHYAC.IRQKGGYCSW
A7SSJ1_NEMVE/20-204EHLYCRLRRDGATCGW
Q9GPJ2_CRAGI/21-203KYGFC.LPDIFGVCYW
TIMP1_MOUSE/23-199RHFAC.LPRNPGLCTW
TIMP4_RAT/28-207QHYVC.MKHVDGICSW
Q16IW9_AEDAE/30-198TRGYL.IDGSPAKCHW
TIMP1_HUMAN/22-199RHLAC.LPREPGLCTW
F6NH88_DANRE/71-248QHYTC.VKRSDSSCAW
H2LU60_ORYLA/26-204KHYAC.IKRNDDSCAW
H2SZH2_TAKRU/30-202RHYAC.IQQKEGYCSW
H2USP3_TAKRU/28-207RQYAC.IRRSDTTCSW
H3C979_TETNG/26-206NHYAC.IKRADRSCSW
H3CWM8_TETNG/28-206KHFAC.IKRSDDSCAW

PF01759

Q8WPD8_CIOIN/1602-1707----------------
Q8I7P1_9CNID/1611-1718----------------
Q8MX24_ANCCA/29-132----------------
Q5NKN5_CARRO/1605-1719----------------
CO3_EPTBU/1496-1605----------------
CO3_LETCA/1543-1654----------------
Q9I933_CYPCA/1566-1681----------------
Q91741_XENLA/1554-1664----------------
Q76KI4_TRISC/1564-1675----------------
Q9I932_CYPCA/1587-1697----------------
Q7SZG2_TAKRU/1574-1684----------------
Q4RHV3_TETNG/135-245----------------
Q70TF5_ONCMY/1595-1705----------------
Q9IBG9_ORYLA/1588-1699----------------
Q076D6_CHICK/1536-1646----------------
CO4A_HUMAN/1615-1725----------------
Q62238_MOUSE/465-575----------------
Q969A4_BRABE/1602-1713----------------
Q8AYN9_CYPCA/1560-1672----------------
Q4SXM5_TETNG/1606-1718----------------
Q6VPV1_PIG/1548-1659----------------
Q99KX9_MOUSE/254-364----------------
CO5_HUMAN/1550-1661----------------
Q4SVH8_TETNG/1716-1828----------------
A5PMP6_DANRE/1549-1662----------------
Q9W6G1_PROAT/775-885----------------
Q91588_9PIPI/1460-1570----------------
VCO32_AUSSU/1522-1632----------------
VCO3_NAJKA/1513-1623----------------
Q90633_CHICK/1523-1633----------------
Q3L2T4_MACEU/1523-1632----------------
CO3_RABIT/597-707----------------
CO3_BOVIN/1532-1642----------------
A6MK21_CALJA/94-204----------------
CO3_RAT/1534-1644----------------
Q9DDV9_ONCMY/1553-1662----------------
Q98977_ONCMY/1484-1594----------------
Q3L5A8_GADMO/75-188----------------
Q98TS6_ANAMI/1526-1643----------------
Q4S019_TETNG/1311-1428----------------
Q9IBH1_ORYLA/1522-1639----------------
Q4RJA3_TETNG/792-902----------------
Q4RZT6_TETNG/1515-1632----------------
CO3_ONCMY/1507-1621----------------
Q3MU73_DANRE/1522-1632----------------
Q9YIA6_CYPCA/1030-1140----------------
Q6UAQ6_CTEID/1510-1620----------------
Q9YIA9_CYPCA/1513-1623----------------
Q4S5G7_TETNG/453-556----------------
O44344_STRPU/1565-1680----------------
A7SX91_NEMVE/256-359----------------
Q4RGB2_TETNG/197-294----------------
A3KNP6_DANRE/185-282----------------
Q32PN6_DANRE/181-278----------------
Q6GZK1_ORYLA/191-288----------------
Q3KQ69_XENLA/197-293----------------
SFRP5_HUMAN/195-293----------------
Q4SKX3_TETNG/205-303----------------
SFRP1_MOUSE/200-296----------------
SFRP1_CHICK/200-296----------------
A4IGU5_XENTR/180-278----------------
L8I1X6_9CETA/186-284----------------
Q7ZXM6_XENLA/190-288----------------
Q32SK8_DANRE/445-554----------------
Q0VEM1_MOUSE/517-624----------------
Q4RSD5_TETNG/491-599----------------
Q4S5B2_TETNG/454-562----------------
Q2HJB6_BOVIN/340-444----------------
Q3UIP2_MOUSE/353-457----------------
PCOC1_HUMAN/330-434----------------
Q7ZWR8_XENLA/379-484----------------
Q66IT1_XENLA/372-477----------------
Q1RMV2_BOVIN/310-413----------------
PCOC2_MOUSE/308-411----------------
Q4S4Z9_TETNG/252-355----------------
Q52L01_XENLA/302-405----------------
SFRP4_HUMAN/188-289----------------
O08570_MESAU/127-229----------------
Q32N13_XENLA/189-292----------------
Q9W6E0_DANRE/200-303----------------
Q4S9P7_TETNG/197-299----------------
X6R4H8_HUMAN/364-467----------------
A7SBN2_NEMVE/182-284----------------
Q9NL28_CIOIN/535-642----------------
Q95YK2_CIOSA/556-663----------------
A0A9Q8_MOLTE/181-286----------------
A7SHI5_NEMVE/436-545----------------
UNC6_CAEEL/491-597----------------
Q0IGC3_AEDAE/141-257----------------
O96659_HIRME/495-600----------------
Q4SF52_TETNG/899-1011----------------
Q0V9H1_XENTR/485-591----------------
NET5_MOUSE/314-431----------------
NET5_HUMAN/361-468----------------
Q52KG2_MOUSE/457-570----------------
K7CDB2_PANTR/488-594----------------
O42203_DANRE/487-595----------------
NET3_CHICK/465-571----------------
Q32SK9_DANRE/482-590----------------
Q9NFW6_BRAFL/441-548----------------
Q59JG2_HEMPU/509-616----------------
Q1PHQ2_SACKO/484-590----------------

PF03146

H2XU25_CIOIN/62-176----------------
T1EVC4_HELRO/36-148----------------
F7G642_MACMU/30-145----------------
W4XF61_STRPU/38-146----------------
K1QM75_CRAGI/2-104----------------
E5SMP2_TRISP/30-136----------------
C3XQ33_BRAFL/36-153----------------
G3S0P3_GORGO/17-132----------------
T1ISD8_STRMM/23-124----------------
H2TJD1_TAKRU/9-124----------------
T1KCH0_TETUR/42-143----------------

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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