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28  structures 6711  species 7  interactions 13605  sequences 36  architectures

Clan: CheC-like (CL0355)


CheC-like superfamily Add an annotation

The chemotactic response regulator superfamily are CheY-P phosphatases. Their structure is two intertwined alpha-beta-(X)-beta(2) motifs. This superfamily comprises two classes of proteins each shown to interact with the chemotaxis response regulator CheY: the FliM switch proteins and the CheC-type phosphatases [1]. FliM is a component of the flagellar switch found across the bacteria and is responsible for binding CheY-P and changing the rotational direction of the flagella. The N-terminal domain is CheC-like and the C-terminal shares the SpoA domain with FliN and FliY. The CheC family is broadly broken down into three phosphatase subfamilies: CheC, CheX, and FliY. All three have an active site consensus sequence of D/S-X(3)-E-X(2)-N-X(22)-P.

This clan contains 4 families and the total number of domains in the clan is 13605. The clan was built by A Bateman and TJ Tuff.

Literature references

  1. Muff TJ, Ordal GW;, Mol Microbiol. 2008;70:1054-1061.: The diverse CheC-type phosphatases: chemotaxis and beyond. PUBMED:18990184 EPMC:18990184


This clan contains the following 4 member families:

CheC CheX DUF3334 FliM

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
FliM (PF02154) 6653 (48.9%) View
CheC (PF04509) 4369 (32.1%) View
CheX (PF13690) 2167 (15.9%) View
DUF3334 (PF11813) 416 (3.1%) View
Total: 4 Total: 13605 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 7 interactions for this clan. More...

Interacting families
CheC CheC
CheX CheX
FliG_M FliM
FliM FliG_M
Response_reg CheC


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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