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176  structures 2788  species 13  interactions 211666  sequences 7892  architectures

Clan: C2H2-zf (CL0361)


Classical C2H2 and C2HC zinc fingers Add an annotation

Superfamily of classical and closely related C2H2 or beta-beta-alpha zinc finger DNA-binding domains.

This clan contains 27 families and the total number of domains in the clan is 211666. The clan was built by P Coggill.


This clan contains the following 27 member families:

DUF3449 GAGA Sgf11 zf-AD zf-BED zf-C2H2 zf-C2H2_10 zf-C2H2_11 zf-C2H2_2 zf-C2H2_3 zf-C2H2_4 zf-C2H2_6 zf-C2H2_7 zf-C2H2_8 zf-C2H2_aberr zf-C2H2_jaz zf-C2HC_2 zf-DBF zf-Di19 zf-H2C2 zf-H2C2_2 zf-H2C2_5 zf-H3C2 zf-LYAR zf-met zf-met2 zf-U1

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-C2H2 (PF00096) 99707 (47.1%) View
zf-C2H2_6 (PF13912) 43099 (20.4%) View
zf-met (PF12874) 20105 (9.5%) View
zf-H2C2_5 (PF13909) 18291 (8.6%) View
zf-C2H2_4 (PF13894) 7467 (3.5%) View
zf-C2H2_jaz (PF12171) 4210 (2.0%) View
zf-AD (PF07776) 3073 (1.5%) View
zf-BED (PF02892) 2456 (1.2%) View
zf-H2C2_2 (PF13465) 2274 (1.1%) View
zf-C2HC_2 (PF13913) 2035 (1.0%) View
zf-C2H2_2 (PF12756) 1583 (0.7%) View
zf-U1 (PF06220) 1236 (0.6%) View
zf-Di19 (PF05605) 1203 (0.6%) View
zf-H2C2 (PF09337) 1060 (0.5%) View
Pfam family Num. domains Alignment
DUF3449 (PF11931) 657 (0.3%) View
zf-C2H2_3 (PF13878) 623 (0.3%) View
zf-LYAR (PF08790) 555 (0.3%) View
zf-DBF (PF07535) 507 (0.2%) View
Sgf11 (PF08209) 426 (0.2%) View
zf-met2 (PF12907) 346 (0.2%) View
zf-C2H2_11 (PF16622) 304 (0.1%) View
zf-C2H2_7 (PF15269) 109 (0.1%) View
GAGA (PF09237) 106 (0.1%) View
zf-H3C2 (PF16721) 76 (0.0%) View
zf-C2H2_8 (PF15909) 69 (0.0%) View
zf-C2H2_10 (PF16588) 61 (0.0%) View
zf-C2H2_aberr (PF17017) 28 (0.0%) View
Total: 27 Total: 211666 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 13 interactions for this clan. More...

Interacting families
DUF3449 PRP21_like_P
GATA zf-C2H2_6
Pkinase zf-DBF
UCH Sgf11
zf-C2H2 zf-C2H2
zf-C2H2_2 zf-C2H2_2
zf-C2H2_4 zf-C2H2_4
zf-C2H2_6 zf-H2C2_2
zf-C2H2_jaz DUF3449
zf-H2C2_2 zf-C2H2
zf-H2C2_5 zf-H2C2_5


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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