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197  structures 7797  species 11  interactions 22756  sequences 358  architectures

Clan: JAB (CL0366)


JAB-like superfamily Add an annotation

This superfamily includes a number of proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits, regulators of transcription factors and ubiquitination-assisting protein families. In eukaryotes and in prokaryotic cognates of the ubiquitin-based modification pathway, they function as ubiquitin isopeptidases/ deubiquitinases. JAB domains are also found in diverse metabolic pathways in prokaryotes such as siderophore and cysteine biosynthesis. Other distinct versions of the JAB domain, such as RadC are predicted to function as nucleases. Structurally, the JAB domain is related to the nucleotide deaminase and binds a Zinc ion in a similar structural location.

This clan contains 6 families and the total number of domains in the clan is 22756. The clan was built by A BatemanLM IyerD Zhang and L Aravind.


This clan contains the following 6 member families:

JAB NPL4 Prok-JAB RadC Toxin-JAB1 UPF0172

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
JAB (PF01398) 9555 (42.0%) View
RadC (PF04002) 7688 (33.8%) View
Prok-JAB (PF14464) 3255 (14.3%) View
NPL4 (PF05021) 1385 (6.1%) View
UPF0172 (PF03665) 813 (3.6%) View
Toxin-JAB1 (PF15659) 60 (0.3%) View
Total: 6 Total: 22756 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 11 interactions for this clan. More...

Interacting families
MitMem_reg JAB
PC_rep JAB
Prok-JAB Prok-JAB
RadC RadC
Sec63 JAB
ubiquitin JAB


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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