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345  structures 4003  species 13  interactions 18678  sequences 276  architectures

Clan: GHD (CL0369)


Glycosyl hydrolase domain superfamily Add an annotation

This domain is C-terminal to the catalytic beta/alpha barrel domain. The superfamily includes the C-terminal domain of a number of sugar-lytic families.

This clan contains 8 families and the total number of domains in the clan is 18678. The clan was built by A Bateman.


This clan contains the following 8 member families:

Alpha-amylase_C CBM_20 CBM_48 Cyc-maltodext_C DUF1939 DUF1966 DUF3459 Glyco_hydro_42C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CBM_48 (PF02922) 8560 (45.8%) View
Alpha-amylase_C (PF02806) 4792 (25.7%) View
DUF3459 (PF11941) 2445 (13.1%) View
CBM_20 (PF00686) 1301 (7.0%) View
Glyco_hydro_42C (PF08533) 633 (3.4%) View
DUF1939 (PF09154) 520 (2.8%) View
DUF1966 (PF09260) 219 (1.2%) View
Cyc-maltodext_C (PF10438) 208 (1.1%) View
Total: 8 Total: 18678 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 13 interactions for this clan. More...

Interacting families
Cyc-maltodext_C Alpha-amylase
Glyco_hydro_42C Glyco_hydro_42
DUF1939 Alpha-amylase
CBM_20 Alpha-amylase
DUF1966 Alpha-amylase
Alpha-amylase_C Alpha-amylase
CBM_48 Alpha-amylase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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