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494  structures 17238  species 21  interactions 74219  sequences 493  architectures

Clan: GHD (CL0369)

Summary

Glycosyl hydrolase domain superfamily Add an annotation

This domain is C-terminal to the catalytic beta/alpha barrel domain. The superfamily includes the C-terminal domain of a number of sugar-lytic families.

This clan contains 10 families and the total number of domains in the clan is 74219. The clan was built by A Bateman.

Members

This clan contains the following 10 member families:

Alpha-amylase_C AMPK1_CBM CBM_20 CBM_48 Cyc-maltodext_C DUF1939 DUF1966 DUF3459 Glyco_hydro_42C Malt_amylase_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CBM_48 (PF02922) 27589 (37.2%) View
Alpha-amylase_C (PF02806) 16801 (22.6%) View
Malt_amylase_C (PF16657) 11120 (15.0%) View
DUF3459 (PF11941) 9974 (13.4%) View
CBM_20 (PF00686) 2560 (3.4%) View
AMPK1_CBM (PF16561) 2443 (3.3%) View
Glyco_hydro_42C (PF08533) 1686 (2.3%) View
DUF1939 (PF09154) 1227 (1.7%) View
Cyc-maltodext_C (PF10438) 495 (0.7%) View
DUF1966 (PF09260) 324 (0.4%) View
Total: 10 Total: 74219 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 21 interactions for this clan. More...

Interacting families
A B
Alpha-amylase Alpha-amylase_C
CBM_20
CBM_48
Cyc-maltodext_C
DUF1939
DUF1966
DUF3459
Alpha-amylase_C Alpha-amylase
Alpha-amylase_C
CBM_48
TIG
CBM_20 CBM_20
Glyco_hydro_14
CBM_48 Alpha-amylase
Cyc-maltodext_C Alpha-amylase
DUF1966 Alpha-amylase
Glyco_hydro_14 CBM_20
Glyco_hydro_15 CBM_20
Glyco_hydro_42 Glyco_hydro_42C
Glyco_hydro_42M Glyco_hydro_42C
TIG CBM_20

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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