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1174  structures 7203  species 39  interactions 76165  sequences 1736  architectures

Clan: GHD (CL0369)

Summary

Glycosyl hydrolase domain superfamily Add an annotation

This domain is C-terminal to the catalytic beta/alpha barrel domain. The superfamily includes the C-terminal domain of a number of sugar-lytic families.

This clan contains 39 families and the total number of domains in the clan is 76165. The clan was built by A Bateman.

Members

This clan contains the following 39 member families:

Alpha-amyl_C Alpha-amyl_C2 Alpha-amylase_C Alpha-L-AF_C AMPK1_CBM Bac_A_amyl_C BetaGal_dom2 CBM_20 CBM_48 Collagen_bind_2 Cyc-maltodext_C DUF1921 DUF1923 DUF1939 DUF1945 DUF1953 DUF1964 DUF1966 DUF3372 DUF3459 Fucosidase_C GH97_C GHD GlgX_C Glyc_hyd_38C_2 Glyco_hyd_101C Glyco_hydro38C2 Glyco_hydro_30C Glyco_hydro_36C Glyco_hydro_42C Glyco_hydro_5_C HepII_C hGDE_central Lact_bio_phlase LBP_C Malt_amylase_C Melibiase_2_C Melibiase_C SpuA_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CBM_48 (PF02922) 14945 (19.6%) View
Alpha-amylase_C (PF02806) 8576 (11.3%) View
DUF3459 (PF11941) 5019 (6.6%) View
Malt_amylase_C (PF16657) 4988 (6.5%) View
AMPK1_CBM (PF16561) 4544 (6.0%) View
Alpha-L-AF_C (PF06964) 4430 (5.8%) View
Melibiase_C (PF17801) 3909 (5.1%) View
CBM_20 (PF00686) 3908 (5.1%) View
Glyco_hydro38C2 (PF17677) 3523 (4.6%) View
Glyco_hydro_30C (PF17189) 2855 (3.7%) View
Glyco_hydro_36C (PF16874) 2551 (3.3%) View
GH97_C (PF14509) 2319 (3.0%) View
GHD (PF17834) 1961 (2.6%) View
Glyco_hydro_42C (PF08533) 1715 (2.3%) View
Fucosidase_C (PF16757) 1410 (1.9%) View
Glyco_hydro_5_C (PF18564) 1256 (1.6%) View
BetaGal_dom2 (PF10435) 1158 (1.5%) View
hGDE_central (PF14702) 1004 (1.3%) View
DUF3372 (PF11852) 932 (1.2%) View
DUF1966 (PF09260) 803 (1.1%) View
continued
Pfam family Num. domains Alignment
Cyc-maltodext_C (PF10438) 717 (0.9%) View
Alpha-amyl_C2 (PF07821) 709 (0.9%) View
Collagen_bind_2 (PF12904) 610 (0.8%) View
DUF1939 (PF09154) 503 (0.7%) View
Melibiase_2_C (PF17450) 452 (0.6%) View
Lact_bio_phlase (PF09508) 303 (0.4%) View
LBP_C (PF17386) 289 (0.4%) View
Glyco_hyd_101C (PF17451) 227 (0.3%) View
GlgX_C (PF18390) 172 (0.2%) View
SpuA_C (PF18033) 122 (0.2%) View
Bac_A_amyl_C (PF18612) 94 (0.1%) View
HepII_C (PF18675) 58 (0.1%) View
Glyc_hyd_38C_2 (PF18230) 40 (0.1%) View
DUF1964 (PF09244) 35 (0.0%) View
DUF1921 (PF09081) 18 (0.0%) View
Alpha-amyl_C (PF09071) 5 (0.0%) View
DUF1945 (PF09178) 2 (0.0%) View
DUF1923 (PF09083) 2 (0.0%) View
DUF1953 (PF09196) 1 (0.0%) View
Total: 39 Total: 76165 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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