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74  structures 1155  species 8  interactions 2519  sequences 122  architectures

Clan: Hy-ly_N (CL0372)


Hyaluronate lyase-like catalytic, N-terminal domain Add an annotation

This contains virus envelope protein, Chondroitin AC lyase and hyaluronate lyase families.

This clan contains 5 families and the total number of domains in the clan is 2519. The clan was built by A Bateman.


This clan contains the following 5 member families:

Alginate_lyase Baculo_E66 Hepar_II_III_N Lyase_8_N Lyase_catalyt

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Alginate_lyase (PF05426) 1278 (50.7%) View
Hepar_II_III_N (PF16889) 608 (24.1%) View
Lyase_8_N (PF08124) 502 (19.9%) View
Lyase_catalyt (PF09093) 129 (5.1%) View
Baculo_E66 (PF04850) 2 (0.1%) View
Total: 5 Total: 2519 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 8 interactions for this clan. More...

Interacting families
Alginate_lyase Alginate_lyase
Lyase_8_C Lyase_8_N
Lyase_8_N Baculo_E66
Lyase_catalyt Lyase_8
Lyase_N Lyase_catalyt


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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