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733  structures 9775  species 18  interactions 115813  sequences 805  architectures

Clan: Metallo-HOrase (CL0381)


Metallo-hydrolase/oxidoreductase superfamily Add an annotation

This superfamily of enzymes including beta-lactamases, thiolesterases, members of the glyoxalase II family that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid all bind two ions of zinc. An additional family of competence proteins essential for natural transformation do not appear to bind zinc, and might be a transporter involved in DNA uptake.

This clan contains 9 families and the total number of domains in the clan is 115813. The clan was built by A Bateman.

Literature references

  1. Carfi A, Pares S, Duee E, Galleni M, Duez C, Frere JM, Dideberg O; , EMBO J 1995;14:4914-4921.: The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold. PUBMED:7588620 EPMC:7588620


This clan contains the following 9 member families:

Beta_lactamase3 HAGH_C Lactamase_B Lactamase_B_2 Lactamase_B_3 Lactamase_B_4 Lactamase_B_5 Lactamase_B_6 PDEase_II

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lactamase_B (PF00753) 70367 (60.8%) View
Lactamase_B_2 (PF12706) 26893 (23.2%) View
Lactamase_B_3 (PF13483) 8181 (7.1%) View
HAGH_C (PF16123) 4395 (3.8%) View
Lactamase_B_6 (PF16661) 3826 (3.3%) View
Lactamase_B_4 (PF13691) 1063 (0.9%) View
PDEase_II (PF02112) 961 (0.8%) View
Lactamase_B_5 (PF14597) 102 (0.1%) View
Beta_lactamase3 (PF17030) 25 (0.0%) View
Total: 9 Total: 115813 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 18 interactions for this clan. More...

Interacting families
Alkyl_sulf_C Lactamase_B
Alkyl_sulf_dimr Lactamase_B
Beta-Casp Lactamase_B
Flavodoxin_1 Lactamase_B
KH_2 Lactamase_B
Lactamase_B Alkyl_sulf_C
Lactamase_B_2 DRMBL
Lactamase_B_5 Lactamase_B_5
Rhodanese Lactamase_B
RMMBL Lactamase_B


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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