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403  structures 5380  species 5  interactions 50665  sequences 305  architectures

Clan: Metallo-HOrase (CL0381)

Summary

Metallo-hydrolase/oxidoreductase superfamily Add an annotation

This superfamily of enzymes including beta-lactamases, thiolesterases, members of the glyoxalase II family that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid all bind two ions of zinc. An additional family of competence proteins essential for natural transformation do not appear to bind zinc, and might be a transporter involved in DNA uptake.

This clan contains 7 families and the total number of domains in the clan is 50665. The clan was built by A Bateman.

Literature references

  1. Carfi A, Pares S, Duee E, Galleni M, Duez C, Frere JM, Dideberg O; , EMBO J 1995;14:4914-4921.: The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold. PUBMED:7588620 EPMC:7588620

Members

This clan contains the following 7 member families:

DUF2070 Lactamase_B Lactamase_B_2 Lactamase_B_3 Lactamase_B_4 Lactamase_B_5 PDEase_II

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lactamase_B (PF00753) 34807 (68.7%) View
Lactamase_B_2 (PF12706) 12584 (24.8%) View
Lactamase_B_3 (PF13483) 2488 (4.9%) View
PDEase_II (PF02112) 323 (0.6%) View
Lactamase_B_4 (PF13691) 279 (0.6%) View
DUF2070 (PF09843) 170 (0.3%) View
Lactamase_B_5 (PF14597) 14 (0.0%) View
Total: 7 Total: 50665 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
Lactamase_B Flavodoxin_1
Lactamase_B
CW_binding_1
RMMBL
Beta-Casp

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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