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178  structures 9750  species 0  interactions 78131  sequences 499  architectures

Clan: DNA-mend (CL0382)


DNA breaking-rejoining enzyme superfamily Add an annotation

This is a superfamily of DNA recombinases, topoisomerases and integrases.

This clan contains 10 families and the total number of domains in the clan is 78131. The clan was built by A Bateman.


This clan contains the following 10 member families:

DUF3435 DUF3504 Flp_C Integrase_1 NDC10_II Phage_Integr_2 Phage_integr_3 Phage_integrase Telomere_res Topoisom_I

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Phage_integrase (PF00589) 67609 (86.5%) View
Topoisom_I (PF01028) 4434 (5.7%) View
DUF3504 (PF12012) 2261 (2.9%) View
DUF3435 (PF11917) 2108 (2.7%) View
NDC10_II (PF16787) 1030 (1.3%) View
Integrase_1 (PF12835) 401 (0.5%) View
Telomere_res (PF16684) 110 (0.1%) View
Phage_Integr_2 (PF13009) 93 (0.1%) View
Phage_integr_3 (PF16795) 77 (0.1%) View
Flp_C (PF05202) 8 (0.0%) View
Total: 10 Total: 78131 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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