Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
121  structures 21425  species 10  interactions 197337  sequences 313  architectures

Clan: DNA-mend (CL0382)


DNA breaking-rejoining enzyme superfamily Add an annotation

This is a superfamily of DNA recombinases, topoisomerases and integrases.

This clan contains 8 families and the total number of domains in the clan is 197337. The clan was built by A Bateman.


This clan contains the following 8 member families:

DUF3435 DUF3504 Flp_C Integrase_1 Phage_Integr_2 Phage_integr_3 Phage_integrase Topoisom_I

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Phage_integrase (PF00589) 190646 (96.6%) View
Topoisom_I (PF01028) 2875 (1.5%) View
Integrase_1 (PF12835) 2122 (1.1%) View
DUF3435 (PF11917) 753 (0.4%) View
DUF3504 (PF12012) 678 (0.3%) View
Phage_Integr_2 (PF13009) 154 (0.1%) View
Phage_integr_3 (PF16795) 83 (0.0%) View
Flp_C (PF05202) 26 (0.0%) View
Total: 8 Total: 197337 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 10 interactions for this clan. More...

Interacting families
Flp_C Flp_C
Flp_N Flp_C
Phage_int_SAM_1 Phage_integrase
Phage_int_SAM_4 Phage_integrase
Phage_integrase Phage_int_SAM_4
Topoisom_I Topo_C_assoc
Topoisom_I_N Topoisom_I
VirDNA-topo-I_N Topoisom_I


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...