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184  structures 1231  species 3  interactions 20485  sequences 1096  architectures

Clan: zf-FYVE-PHD (CL0390)


FYVE/PHD zinc finger superfamily Add an annotation

Superfamily contains a number of zinc-fingers, of the FYVE/PHD type, which are found in several groups of proteins including myelin-associated oligodendrocytic basic proteins (MOBP) Rabphilins, melanophilins, exophilins and myosin-VIIA and Rab-interacting protein families.

This clan contains 9 families and the total number of domains in the clan is 20485. The clan was built by P Coggill.


This clan contains the following 9 member families:

FYVE FYVE_2 PHD PHD_2 RAG2_PHD zf-HC5HC2H zf-HC5HC2H_2 zf-PHD-like zf-piccolo

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PHD (PF00628) 10006 (48.8%) View
FYVE (PF01363) 4289 (20.9%) View
zf-HC5HC2H_2 (PF13832) 1557 (7.6%) View
PHD_2 (PF13831) 1358 (6.6%) View
zf-HC5HC2H (PF13771) 1247 (6.1%) View
RAG2_PHD (PF13341) 1007 (4.9%) View
FYVE_2 (PF02318) 739 (3.6%) View
zf-piccolo (PF05715) 212 (1.0%) View
zf-PHD-like (PF15446) 70 (0.3%) View
Total: 9 Total: 20485 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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