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4  structures 92  species 0  interactions 187  sequences 9  architectures

Clan: GG-leader (CL0400)


Double-Glycine leader-peptide cleavage motif Add an annotation

This is a collection of short bacterial families that carry a distinctive GG-cleavage motif. Conservation C-terminal to the GG-motif is not apparent. However, the families are all interconnected with critical virulence attributes of one kind or another.

This clan contains 5 families and the total number of domains in the clan is 187. The clan was built by P Coggill.


This clan contains the following 5 member families:

Antimicrobial17 Bacteriocin_IIc ComC L_biotic_typeA Lactococcin

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Bacteriocin_IIc (PF10439) 108 (57.8%) View
ComC (PF03047) 58 (31.0%) View
L_biotic_typeA (PF04604) 17 (9.1%) View
Lactococcin (PF04369) 4 (2.1%) View
Antimicrobial17 (PF08129) 0 (0.0%) View
Total: 5 Total: 187 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...