Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
674  structures 8775  species 0  interactions 15107  sequences 333  architectures

Clan: LEF-8-like (CL0410)


LEF-8 like region of RNA polymerase Rpb2 Add an annotation

Late expression factor 8 (LEF-8) is one of the primary components of RNA polymerase produced by polyhedrosis viruses. LEF-8 shows homology to domain 6 of the second largest subunit of prokaryotic DNA-directed RNA polymerase[1].

This clan contains 2 families and the total number of domains in the clan is 15107. The clan was built by J Mistry and RD Finn.

Literature references

  1. Acharya A, Gopinathan KP; , J Gen Virol 2002;83:2015-2023.: Characterization of late gene expression factors lef-9 and lef-8 from Bombyx mori nucleopolyhedrovirus. PUBMED:12124466 EPMC:12124466


This clan contains the following 2 member families:

LEF-8 RNA_pol_Rpb2_6

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RNA_pol_Rpb2_6 (PF00562) 15087 (99.9%) View
LEF-8 (PF04941) 20 (0.1%) View
Total: 2 Total: 15107 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...