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4  structures 797  species 0  interactions 8031  sequences 167  architectures

Clan: Anoctamin-like (CL0416)


Transmembrane protein families of the Anoctamin type Add an annotation

The families are transmembrane families, where some of the members have sodium tolerance activity.

This clan contains 3 families and the total number of domains in the clan is 8031. The clan was built by RD Finn and P Coggill.


This clan contains the following 3 member families:

Anoctamin RSN1_7TM TMC

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RSN1_7TM (PF02714) 3868 (48.2%) View
Anoctamin (PF04547) 3156 (39.3%) View
TMC (PF07810) 1007 (12.5%) View
Total: 3 Total: 8031 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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