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457  structures 2753  species 0  interactions 77812  sequences 1042  architectures

Clan: PF (CL0431)

Summary

Profilin-like superfamily Add an annotation

The families here all show the Profilin-like fold, and represent both the Profilin (actin-binding protein) (55770) and the Roadblock/LC7 domain-type (103196) superfamilies.

This clan contains 21 families and the total number of domains in the clan is 77812. The clan was built by A Bateman.

Members

This clan contains the following 21 member families:

Clat_adaptor_s FNIP_N Fuz_longin_1 Fuz_longin_2 Fuz_longin_3 Intu_longin_1 Intu_longin_2 Intu_longin_3 LAMTOR5 Longin Longin_2 MAPKK1_Int Nyv1_longin Profilin Robl_LC7 Sedlin_N SLM4 SRP-alpha_N SRX Sybindin uDENN

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Clat_adaptor_s (PF01217) 17353 (22.3%) View
uDENN (PF03456) 12794 (16.4%) View
Robl_LC7 (PF03259) 9334 (12.0%) View
Longin (PF13774) 8032 (10.3%) View
Profilin (PF00235) 3901 (5.0%) View
Sedlin_N (PF04628) 3584 (4.6%) View
Sybindin (PF04099) 3476 (4.5%) View
Fuz_longin_1 (PF19036) 3142 (4.0%) View
Fuz_longin_2 (PF19037) 3081 (4.0%) View
Fuz_longin_3 (PF19038) 2853 (3.7%) View
Intu_longin_1 (PF19031) 2665 (3.4%) View
continued
Pfam family Num. domains Alignment
SRP-alpha_N (PF04086) 1876 (2.4%) View
FNIP_N (PF14636) 1548 (2.0%) View
Intu_longin_3 (PF19033) 1517 (1.9%) View
Intu_longin_2 (PF19032) 1195 (1.5%) View
MAPKK1_Int (PF08923) 659 (0.8%) View
LAMTOR5 (PF16672) 624 (0.8%) View
Longin_2 (PF18639) 68 (0.1%) View
SLM4 (PF16818) 56 (0.1%) View
SRX (PF09201) 28 (0.0%) View
Nyv1_longin (PF09426) 26 (0.0%) View
Total: 21 Total: 77812 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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