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174  structures 2264  species 5  interactions 9898  sequences 108  architectures

Clan: PF (CL0431)


Profilin-like superfamily Add an annotation

The families here all show the Profilin-like fold, and represent both the Profilin (actin-binding protein) (55770) and the Roadblock/LC7 domain-type (103196) superfamilies.

This clan contains 4 families and the total number of domains in the clan is 9898. The clan was built by A Bateman.


This clan contains the following 4 member families:

LAMTOR5 MAPKK1_Int Profilin Robl_LC7

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Robl_LC7 (PF03259) 6888 (69.6%) View
Profilin (PF00235) 2247 (22.7%) View
MAPKK1_Int (PF08923) 403 (4.1%) View
LAMTOR5 (PF16672) 360 (3.6%) View
Total: 4 Total: 9898 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families
Actin Profilin
Arf Robl_LC7
MAPKK1_Int Robl_LC7
Profilin Profilin
Robl_LC7 Robl_LC7


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...