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688  structures 2255  species 24  interactions 9072  sequences 375  architectures

Clan: Sialidase (CL0434)

Summary

Sialidase superfamily Add an annotation

This superfamily includes sialidases enzymes. Several viruses use sialic acid as a cell surface receptor for host invasion. These viruses then have cell surface neuraminidase enzymes to cleave sialic acid from cell surface proteins allowing them to leave the host cell after replication. This superfamily are composed of six beta-sheets that form a six-fold beta-propeller structure. Many members of this superfamily contain BNR sequence motifs Pfam:PF02012.

This clan contains 11 families and the total number of domains in the clan is 9072. The clan was built by A Bateman.

Literature references

  1. Taylor G;, Curr Opin Struct Biol. 1996;6:830-837.: Sialidases: structures, biological significance and therapeutic potential. PUBMED:8994884 EPMC:8994884

Members

This clan contains the following 11 member families:

BNR BNR_2 BNR_3 BNR_4 BNR_6 End_beta_barrel End_beta_propel HN Neur PSII_BNR Sortilin-Vps10

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Sortilin-Vps10 (PF15902) 2675 (29.5%) View
BNR_2 (PF13088) 2189 (24.1%) View
BNR_3 (PF13859) 1733 (19.1%) View
PSII_BNR (PF14870) 1426 (15.7%) View
BNR (PF02012) 482 (5.3%) View
BNR_4 (PF15892) 448 (4.9%) View
BNR_6 (PF15899) 104 (1.1%) View
HN (PF00423) 7 (0.1%) View
Neur (PF00064) 6 (0.1%) View
End_beta_propel (PF12217) 1 (0.0%) View
End_beta_barrel (PF12195) 1 (0.0%) View
Total: 11 Total: 9072 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 24 interactions for this clan. More...

Interacting families
A B
BNR BNR_2
BNR_2 BNR_2
BNR_3 Laminin_G_3
BNR_assoc_N BNR_2
End_beta_barrel End_beta_propel
End_tail_spike
End_beta_propel End_beta_barrel
End_beta_propel
End_N_terminal
End_tail_spike
End_N_terminal End_beta_propel
End_tail_spike End_beta_barrel
End_beta_propel
Ephrin HN
HN Ephrin
HN
SLAM
Sushi
V-set
Neur Neur
V-set
Sial-lect-inser BNR_2
Sialidase BNR_2
SLAM HN

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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