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100  structures 21076  species 20  interactions 137736  sequences 170  architectures

Clan: EF-G_C (CL0437)

Summary

Transcription elongation factor G C-terminal Add an annotation

This superfamily is characterised by being an alpha-beta 2-Layer Sandwich. It is found in EF2 proteins from both prokaryotes and eukaryotes, as well as in some tetracycline resistance proteins, peptide chain release factors ], and in the C-terminal region of the bacterial hypothetical protein, YigZ.

This clan contains 7 families and the total number of domains in the clan is 137736. The clan was built by P Coggill.

Members

This clan contains the following 7 member families:

DUF1949 EFG_C EFG_II Elong_Iki1 ELP6 RF3_C SBDS_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EFG_C (PF00679) 70189 (51.0%) View
EFG_II (PF14492) 37485 (27.2%) View
RF3_C (PF16658) 14492 (10.5%) View
DUF1949 (PF09186) 13787 (10.0%) View
SBDS_C (PF09377) 994 (0.7%) View
Elong_Iki1 (PF10483) 443 (0.3%) View
ELP6 (PF09807) 346 (0.3%) View
Total: 7 Total: 137736 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 20 interactions for this clan. More...

Interacting families
A B
DUF1949 V-set
EFG_C EFG_C
LepA_C
Ribosomal_L11_N
EFG_II EFG_C
EFG_IV
Exotox-A_cataly
GTP_EFTU
Ribosom_S12_S23
EFG_IV EFG_C
GTP_EFTU EFG_C
EFG_II
GTP_EFTU_D2 EFG_II
PAXNEB Elong_Iki1
Ribosom_S12_S23 EFG_II
Ribosomal_S25 EFG_C
RRF EFG_C
EFG_II
SBDS SBDS_C
SBDS_C SBDS_C

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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