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352  structures 23561  species 15  interactions 34605  sequences 77  architectures

Clan: Tubulin_C (CL0442)


Tubulin, FtsZ and Misato and their C-termini, Add an annotation

This superfamily is characterised by being at the C-terminus of the GTPase-binding region of tubulins.

This clan contains 2 families and the total number of domains in the clan is 34605. The clan was built by P Coggill.

Literature references

  1. Nogales E, Downing KH, Amos LA, Lowe J; , Nat Struct Biol 1998;5:451-458.: Tubulin and FtsZ form a distinct family of GTPases. PUBMED:9628483 EPMC:9628483
  2. Dyer N;, Sci Prog. 2009;92:113-137.: Tubulin and its prokaryotic homologue FtsZ: a structural and functional comparison. PUBMED:19697711 EPMC:19697711
  3. Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Munstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S;, Genomics. 2006;88:143-151.: An anthropoid-specific segmental duplication on human chromosome 1q22. PUBMED:16545939 EPMC:16545939


This clan contains the following 2 member families:

FtsZ_C Tubulin_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
FtsZ_C (PF12327) 21143 (61.1%) View
Tubulin_C (PF03953) 13462 (38.9%) View
Total: 2 Total: 34605 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 15 interactions for this clan. More...

Interacting families
FtsZ_C FtsZ_C
Kinesin Tubulin_C
MHC_I Tubulin_C
MT Tubulin_C
Tubulin FtsZ_C
Tubulin_C CH


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...