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133  structures 1123  species 14  interactions 12692  sequences 249  architectures

Clan: SNARE-fusion (CL0445)


SNARE-fusion membrane complex superfamily Add an annotation

The SNARE-fusion complex families are characterised by being tetrameric coiled-coil structures.

This clan contains 3 families and the total number of domains in the clan is 12692. The clan was built by P Coggill.


This clan contains the following 3 member families:

Synaptobrevin Syntaxin Syntaxin_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Synaptobrevin (PF00957) 6902 (54.4%) View
Syntaxin (PF00804) 4070 (32.1%) View
Syntaxin_2 (PF14523) 1720 (13.6%) View
Total: 3 Total: 12692 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 14 interactions for this clan. More...

Interacting families
ANTH Synaptobrevin
Longin Synaptobrevin
Peptidase_M27 Synaptobrevin
Sec1 Syntaxin
SNARE Synaptobrevin
Synaphin Synaptobrevin
Synaptobrevin Ank_2
Syntaxin SNARE


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...