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0  structures 1083  species 0  interactions 11942  sequences 341  architectures

Clan: G-PATCH (CL0449)


DExH-box splicing factor binding site Add an annotation

This superfamily is characterised by domains which are related to the G-patch domain in proteins with RNA-binding/splicing activity. This domain affects RNA-splicing by binding to a DExH-box splicing factor.

This clan contains 2 families and the total number of domains in the clan is 11942. The clan was built by P Coggill.

Literature references

  1. Silverman EJ, Maeda A, Wei J, Smith P, Beggs JD, Lin RJ;, Mol Cell Biol. 2004;24:10101-10110.: Interaction between a G-patch protein and a spliceosomal DEXD/H-box ATPase that is critical for splicing. PUBMED:15542821 EPMC:15542821
  2. Boon KL, Auchynnikava T, Edwalds-Gilbert G, Barrass JD, Droop AP, Dez C, Beggs JD;, Mol Cell Biol. 2006;26:6016-6023.: Yeast ntr1/spp382 mediates prp43 function in postspliceosomes. PUBMED:16880513 EPMC:16880513


This clan contains the following 2 member families:

G-patch G-patch_2

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
G-patch (PF01585) 10938 (91.6%) View
G-patch_2 (PF12656) 1004 (8.4%) View
Total: 2 Total: 11942 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...