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240  structures 373  species 7  interactions 8677  sequences 528  architectures

Clan: Protease_inhib (CL0454)


Protease inhibitor toxin superfamily Add an annotation

This superfamily includes several families of toxins which seem to act as protease inuibitors.

This clan contains 1 families and the total number of domains in the clan is 8677. The clan was built by P Coggill.


This clan contains the following 1 member families:


Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Kunitz_BPTI (PF00014) 8677 (100.0%) View
Total: 1 Total: 8677 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 7 interactions for this clan. More...

Interacting families
Flavi_NS2B Kunitz_BPTI
Kunitz_BPTI Kunitz_BPTI
Peptidase_M14 Kunitz_BPTI
Peptidase_S7 Kunitz_BPTI
Phospholip_A2_1 Kunitz_BPTI
Trypsin Kunitz_BPTI


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...