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16  structures 1922  species 1  interaction 9476  sequences 242  architectures

Clan: 4HB_MCP (CL0457)

Summary

Aspartate chemoreceptor, signal-transduction ligand-binding Add an annotation

This superfamily is characterised by a four-helix bundle structure that forms a ubiquitous sensory module in prokaryotic signal-transduction. The 4HB_MCP is always found between two predicted transmembrane helices indicating that it detects only extracellular signals. In many cases the domain is associated with a cytoplasmic HAMP domain suggesting that most proteins carrying the bundle might share the mechanism of transmembrane signalling which is well-characterised in E coli chemoreceptors.

This clan contains 3 families and the total number of domains in the clan is 9476. The clan was built by L Ulrich and P Coggill.

Literature references

  1. Ulrich LE, Zhulin IB;, Bioinformatics. 2005;21:iii45-iii48.: Four-helix bundle: a ubiquitous sensory module in prokaryotic signal transduction. PUBMED:16306392 EPMC:16306392

Members

This clan contains the following 3 member families:

4HB_MCP_1 CHASE3 TarH

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
4HB_MCP_1 (PF12729) 4710 (49.7%) View
TarH (PF02203) 3556 (37.5%) View
CHASE3 (PF05227) 1210 (12.8%) View
Total: 3 Total: 9476 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
TarH TarH

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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