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319  structures 9664  species 7  interactions 43308  sequences 375  architectures

Clan: IIaaRS-ABD (CL0458)


Class II aaRS Anticodon-binding domain-like Add an annotation

This superfamily is characterised by including the anticodon-binding domain of Class II aaRS and the Brix domain.

This clan contains 3 families and the total number of domains in the clan is 43308. The clan was built by P Coggill.


This clan contains the following 3 member families:

Brix HGTP_anticodon HGTP_anticodon2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HGTP_anticodon (PF03129) 36726 (84.8%) View
Brix (PF04427) 5734 (13.2%) View
HGTP_anticodon2 (PF12745) 848 (2.0%) View
Total: 3 Total: 43308 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 7 interactions for this clan. More...

Interacting families
HGTP_anticodon HGTP_anticodon
ProRS-C_1 HGTP_anticodon
tRNA-synt_2b HGTP_anticodon
tRNA-synt_His HGTP_anticodon


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...